Quasars as standard candles II

A tight non-linear relation between the X-ray and the optical-ultraviolet (UV) emission has been observed in active galactic nuclei (AGN) over a wide range of redshift and several orders of magnitude in luminosity, suggesting the existence of an ubiquitous physical mechanism regulating the energy transfer between the accretion disc and the X-ray emitting corona. Recently, our group developed a method to use this relation in observational cosmology, turning quasars into standardizable candles. This work mainly seeks to investigate the potential evolution of this correction at high redshifts. We thus studied the LX − LUV relation for a sample of quasars in the redshift range 4 <  z <  7, adopting the selection criteria proposed in our previous work regarding their spectral properties. The resulting sample consists of 53 type 1 (unobscured) quasars, observed either with Chandra or XMM-Newton, for which we performed a full spectral analysis, determining the rest-frame 2 keV flux density, as well as more general X-ray properties such as the estimate of photon index, and the soft (0.5–2 keV) and hard (2–10 keV) unabsorbed luminosities. We find that the relation shows no evidence for evolution with redshift. The intrinsic dispersion of the LX–LUV for a sample free of systematics/contaminants is of the order of 0.22 dex, which is consistent with previous estimates from our group on quasars at lower redshift

AGN impact on the molecular gas in galactic centres as probed by CO lines

We present a detailed analysis of the X-ray, infrared, and carbon monoxide (CO) emission for a sample of 35 local (z ≤ 0.15), active (LX ≥ 1042 erg s-1) galaxies. Our goal is to infer the contribution of far-ultraviolet (FUV) radiation from star formation (SF), and X-ray radiation from the active galactic nuclei (AGNs), respectively, producing photodissociation regions (PDRs) and X-ray-dominated regions (XDRs), to the molecular gas heating. To this aim, we exploit the CO spectral line energy distribution (CO SLED) as traced by Herschel, complemented with data from single-dish telescopes for the low-J lines, and high-resolution ALMA images of the mid-J CO emitting region. By comparing our results to the Schmidt-Kennicutt relation, we find no evidence for AGN influence on the cold and low-density gas on kpc-scales. On nuclear (r = 250 pc) scales, we find weak correlations between the CO line ratios and either the FUV or X-ray fluxes: this may indicate that neither SF nor AGN radiation dominates the gas excitation, at least at r = 250 pc. From a comparison of the CO line ratios with PDR and XDR models, we find that PDRs can reproduce observations only in presence of extremely high gas densities (n &gt; 105 cm-3). In the XDR case, instead, the models suggest moderate densities (n ≈ 102-4 cm-3). We conclude that a mix of the two mechanisms (PDR for the mid-J, XDR, or possibly shocks for the high-J) is necessary to explain the observed CO excitation in active galaxies

The molecular gas properties in local Seyfert 2 galaxies

Aims. We present a multiwavelength study of the molecular gas properties of a sample of local Seyfert 2 galaxies to assess if, and to what extent, the presence of an active galactic nucleus (AGN) can affect the interstellar medium (ISM) properties in a sample of 33 local Seyfert 2 galaxies. Methods. We compare the molecular gas content (MH2) derived from new and archival low-J CO line measurements of a sample of AGN and a control sample of star-forming galaxies (SFGs). Both the AGN and the control sample are characterized in terms of host-galaxy properties, for example stellar and dust masses (M* and Mdust, respectively) and the star formation rate (SFR). We also investigate the effect of AGN activity on the emission of polycyclic aromatic hydrocarbon (PAH) molecules in the mid-infrared (MIR), a waveband where the dust-reprocessed emission from the obscured AGN contributes the most. Result. The AGN hosted in less massive galaxies (i.e., M* &lt; 1010.5 M⊙; Mdust &lt; 107.5 M⊙) show larger molecular gas contents with respect to SFGs that have the same stellar and dust masses. When comparing their depletion times (tdep ≈ MH2/SFR), AGN show tdep ∼ 0.3-1.0 Gyr, similar to the times observed in the control sample of SFGs. Seyfert 2 galaxies show fainter PAH luminosity the larger the dominance of the nuclear activity in the MIR. Conclusions. We find no clear evidence for a systematic reduction in the molecular gas reservoir at galactic scales in Seyfert galaxies with respect to SFGs. This is in agreement with recent studies that show that molecular gas content is only reduced in sub-kiloparsec-sized regions, where emission from the accreting supermassive black hole dominates. Nonetheless, we show that the impact of AGN activity on the ISM is clearly visible as a suppression of the PAH luminosity

The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells.

Dendritic cells (DCs) are professional APCs that have a role in the initiation of adaptive immune responses and tolerance. Among the tolerogenic mechanisms, the expression of the enzyme IDO1 represents an effective tool to generate T regulatory cells. In humans, different DC subsets express IDO1, but less is known about the IDO1-related enzyme IDO2. In this study, we found a different pattern of expression and regulation between IDO1 and IDO2 in human circulating DCs. At the protein level, IDO1 is expressed only in circulating myeloid DCs (mDCs) and is modulated by PGE2, whereas IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. In healthy subjects, IDO1 expression requires the presence of PGE2 and needs continuous transcription and translation, whereas IDO2 expression is constitutive, independent from suppressor of cytokine signaling 3 activity. Conversely, in patients suffering from inflammatory arthritis, circulating DCs express both IDO1 and IDO2. At the functional level, both mDCs and plasmacytoid DCs generate T regulatory cells through an IDO1/IDO2-dependent mechanism. We conclude that, in humans, whereas IDO1 provides an additional mechanism of tolerance induced by proinflammatory mediators, IDO2 is stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs

c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells

Group-2 innate lymphoid cells (ILC2s), which are involved in type 2 inflammatory diseases such as allergy, can exhibit immunological memory, but the basis of this ILC2 "trained immunity" has remained unclear. Here, we found that stimulation with IL-33/IL-25 or exposure to the allergen papain induces the expression of the transcription factor c-Maf in mouse ILC2s. Chronic papain exposure results in high production of IL-5 and IL-13 cytokines and lung eosinophil recruitment, effects that are blocked by c-Maf deletion in ILCs. Transcriptomic analysis revealed that knockdown of c-Maf in ILC2s suppresses expression of type 2 cytokine genes, as well as of genes linked to a memory-like phenotype. Consistently, c-Maf was found highly expressed in human adult ILC2s but absent in cord blood and required for cytokine production in isolated human ILC2s. Furthermore, c-Maf-deficient mouse or human ILC2s failed to exhibit strengthened (“trained”) responses upon repeated challenge. Thus, the expression of c-Maf is indispensable for optimal type 2 cytokine production and proper memory-like responses in group-2 innate lymphoid cells

Toxicity after moderately hypofractionated versus conventionally fractionated prostate radiotherapy: A systematic review and meta-analysis of the current literature

Background: Moderately hypofractionated radiotherapy (RT) currently represents the standard RT approach for all prostate cancer (PCa) risk categories. We performed a systematic review and meta-analysis of available literature, focusing on acute and late genitourinary (GU) and gastrointestinal (GI) adverse events (AEs) of moderate hypofractionation for localized PCa. Materials and methods: Literature search was performed and two independent reviewers selected the records according to the following Population (P) Intervention (I) Comparator (C) and Outcomes (O) (PICO) question: “In patients affected by localized PCa (P), moderately hypofractionated RT (defined as a treatment schedule providing a single dose per fraction of 3–4.5 Gy) (I) can be considered equivalent to conventionally fractionated RT (C) in terms of G &gt; 2 GI and GU acute and late adverse events (O)?”. Bias assessment was performed using Cochrane Cochrane Collaboration's Tool for Assessing Risk of Bias. Results: Thirteen records were identified and a meta-analysis was performed. Risk of acute GI and GU &gt; 2 adverse events in the moderately hypofractionated arm was increased by 9.8 % (95 %CI 4.8 %–14.7 %; I2 = 57 %) and 1.5 % (95 % CI -1.5 %-4.4 %; I2 = 0%), respectively. Discussion: Overall, majority of trials included in our meta-analysis suggested that moderately hypofractionated RT is equivalent, in terms of GI and GU adverse events, to conventional fractionation. Pooled analysis showed a trend to increased GI toxicity after hypofractionated treatment, but this might be related to dose escalation rather than hypofractionation

The most luminous blue quasars at 3.0 < z < 3.3. III. LBT spectra and accretion parameters

We present the analysis of the rest frame ultraviolet and optical spectra of 30 bright blue quasars at z ∼ 3, selected to examine the suitability of active galactic nuclei as cosmological probes. In our previous works, based on pointed XMM-Newton observations, we found an unexpectedly high fraction (≈25%) of X-ray weak quasars in the sample. The latter sources also display a flatter UV continuum and a broader and fainter C IV profile in the archival UV data with respect to their X-ray normal counterparts. Here we present new observations with the Large Binocular Telescope in both the zJ (covering the rest frame ≃2300-3100 Å) and the KS (≃4750-5350 Å) bands. We estimated black hole masses (MBH) and Eddington ratios (λEdd) from the available rest frame optical and UV emission lines (Hβ, Mg II), finding that our z∼3 quasars are on average highly accreting (λEdd≃ 1.2 and MBH≃ 109.7 M⊙), with no difference in λEdd or MBH between X-ray weak and X-ray normal quasars. From the zJ spectra, we derived the properties (e.g. flux, equivalent width) of the main emission lines (Mg II, Fe II), finding that X-ray weak quasars display higher Fe II/Mg II ratios with respect to typical quasars. Fe II/Mg II ratios of X-ray normal quasars are instead consistent with other estimates up to z ≃ 6.5, corroborating the idea of already chemically mature broad line regions at early cosmic time. From the KS spectra, we find that all the X-ray weak quasars present generally weaker [O III] emission (EW &lt; 10 Å) than the normal ones. The sample as a whole, however, abides by the known X-ray-[O III] luminosity correlation, hence the different [O III] properties are likely due to an intrinsically weaker [O III] emission in X-ray weak objects, associated to the shape of the spectral energy distribution. We interpret these results in the framework of accretion-disc winds

Dynamical response function in sodium and aluminum from time-dependent density-functional theory

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Quasars as standard candles: III. Validation of a new sample for cosmological studies

We present a new catalogue of 3c2400 optically selected quasars with spectroscopic redshifts and X-ray observations from either Chandra or XMM-Newton. The sample can be used to investigate the non-linear relation between the ultraviolet (UV) and X-ray luminosity of quasars as well as to build a Hubble diagram up to a redshift of z 3c 7.5. We selected sources that are neither reddened by dust in the optical and UV nor obscured by gas in the X-rays, and whose X-ray fluxes are free from flux-limit-related biases. After checking for any possible systematics, we confirm, in agreement with our previous works, that the X-ray to UV relation provides distance estimates matching those from supernovae up to z 3c 1.5, and its slope shows no redshift evolution up to z 3c 5. We provide a full description of the methodology for testing cosmological models, further supporting a trend whereby the Hubble diagram of quasars is well reproduced by the standard flat cold dark matter model up to z 3c 1.5-2, but strong deviations emerge at higher redshifts. Since we have minimised all non-negligible systematic effects and proven the stability of the LX - LUV relation at high redshifts, we conclude that an evolution of the expansion rate of the Universe should be considered as a possible explanation for the observed deviation, rather than some systematic (redshift-dependent) effect associated with high-redshift quasars