2,532 research outputs found
Development of the health and economic consequences of smoking interactive model
Objective-To describe the health and economic consequences of smoking model, a user friendly, web based tool, designed to estimate the health and economic outcomes associated with smoking and the benefits of smoking cessation. Results-An overview of the development of the model equations and user interface is given, and data from the UK are presented as an example of the model outputs. These results show that a typical smoking cessation strategy costs approximately pound 1200 per life year saved and pound 22 000 per death averted. Conclusions-The model successfully captures the complexity required to model smoking behaviour and associated mortality, morbidity, and health care costs. Furthermore, the interface provides the results in a simple and flexible way so as to be useful to a variety of audiences and to simulate a variety of smoking cessation methods
Naval Power and Expeditionary Warfare: Peripheral Campaigns and New Theatres of Naval Warfare
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Potential sinks for geologic storage of carbon dioxide generated by power plants in North and South Carolina
Duke Energy
Progress Energy
Santee Cooper Power
SCANA CorporationBureau of Economic Geolog
Strong mass effect on ion beam mixing in metal bilayers
Molecular dynamics simulations have been used to study the mechanism of ion
beam mixing in metal bilayers. We are able to explain the ion induced
low-temperature phase stability and melting behavior of bilayers using only a
simple ballistic picture up to 10 keV ion energies. The atomic mass ratio of
the overlayer and the substrate constituents seems to be a key quantity in
understanding atomic mixing. The critical bilayer mass ratio of
is required for the occurrence of a thermal spike (local melting) with a
lifetime of ps at low-energy ion irradiation (1 keV) due to a
ballistic mechanism. The existing experimental data follow the same trend as
the simulated values.Comment: 4 pages, 4 figures, preprin
Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling
Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition
Linear or Rotary Actuator Using Electromagnetic Driven Hammer as Prime Mover
We claim a hammer driven actuator that uses the fast-motion, low-force characteristics of an electro-magnetic or similar prime mover to develop kinetic energy that can be transformed via a friction interface to produce a higher-force, lower-speed linear or rotary actuator by using a hammering process to produce a series of individual steps. Such a system can be implemented using a voice-coil, electro-mechanical solenoid or similar prime mover. Where a typical actuator provides limited range of motion or low force, the range of motion of a linear or rotary impact driven motor can be configured to provide large displacements which are not limited by the characteristic dimensions of the prime mover
Nurses\u27 Alumnae Association Bulletin, April 1962
Staff Nurses Association
Alumnae Meetings 1961
Social Committee
Clara Melville Scholarship Fund
Ways and Means Report
Cook Book Report
Bulletin Committee
Private Duty Nurse\u27s Section
Hospital Report and Nursing Service
Federal Nursing Service
Practice of Nursing
Report of Student Council Activities
Medical Work in Ghan
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