ICAR: endoscopic skull‐base surgery

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International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Personal Papers (MS 80-0002)

Letter from E. C. Roxbury to Warren McDonald advocating for increased funding for the University of Texas Medical School at Galveston. E. C. Roxbury, argues that the school has a high reputation but lacks political influence. He requests that Mr. Wood support the appropriation recommended by the Board of Regents and the Board of Control. He also argues that an additional $150,000 per year would allow the school to admit 40% more students

Personal Papers (MS 80-0002)

Letter from E. C. Roxbury to Will Wood advocating for increased funding for the University of Texas Medical School at Galveston. E. C. Roxbury, argues that the school has a high reputation but lacks political influence. He requests that Mr. Wood support the appropriation recommended by the Board of Regents and the Board of Control. He also argues that an additional $150,000 per year would allow the school to admit 40% more students

Structural Stability and Binding Strength of a Designed Peptide–Carbon Nanotube Hybrid

Biological polymers hybridized with single-walled carbon nanotubes (SWCNTs) have elicited much interest recently for applications in SWCNT-based sorting as well as biomedical imaging, sensing, and drug delivery. Recently, de novo designed peptides forming a coiled-coil structure have been engineered to selectively disperse SWCNT of a certain diameter. Here we report on a study of the binding strength and structural stability of the hybrid between such a “HexCoil-Ala” peptide and the (6,5)-SWCNT. Using the competitive binding of a surfactant, we find that affinity strength of the peptide ranks in comparison to that of two single-stranded DNA sequences as (GT)(30)-DNA > HexCoil-Ala > (TAT)(4)T-DNA. Further, using replica exchange molecular dynamics (REMD), we show that the hexamer peptide complex has both similarities with and differences from the original design. While one of two distinct helix-helix interfaces of the original model was largely retained, a second interface showed much greater variability. These conformational differences allowed an aromatic tyrosine residue designed to lie along the solvent-exposed surface of the protein instead to penetrate between the two helices and directly contact the SWCNT. These insights will inform future designs of SWCNT-interacting peptides

Relationship between subacute brain activity and aphasia recovery

Introduction Recovery from post-stroke aphasia is highly variable and there is currently no effective method of predicting individual recovery to guide rehabilitation. This project addresses the lack of knowledge regarding brain mechanisms responsible for aphasia recovery to provide much needed specificity in determining the best predictors of recovery for language symptoms commonly targeted in rehabilitation. ..