651 research outputs found
Angular Power Spectrum Estimation of Cosmic Ray Anisotropies with Full or Partial Sky Coverage
We study the angular power spectrum estimate in order to search for large
scale anisotropies in the arrival directions distribution of the highest-energy
cosmic rays. We show that this estimate can be performed even in the case of
partial sky coverage and validated over the full sky under the assumption that
the observed fluctuations are statistically spatial stationary. If this
hypothesis - which can be tested directly on the data - is not satisfied, it
would prove, of course, that the cosmic ray sky is non isotropic but also that
the power spectrum is not an appropriate tool to represent its anisotropies,
whatever the sky coverage available. We apply the method to simulations of the
Pierre Auger Observatory, reconstructing an input power spectrum with the
Southern site only and with both Northern and Southern ones. Finally, we show
the improvement that a full-sky observatory brings to test an isotropic
distribution, and we discuss the sensitivity of the Pierre Auger Observatory to
large scale anisotropies.Comment: 16 pages, 6 figures, version accepted for publication by JCA
An iterative destriping technique for diffuse background polarization data
We describe a simple but effective iterative procedure specifically designed
to destripe Q and U Stokes parameter data as those collected by the SPOrt
experiment onboard the International Space Station (ISS). The method is general
enough to be useful for other experiments, both in polarization and total
intensity. The only requirement for the algorithm to work properly is that the
receiver knee frequency must be lower than the signal modulation frequency,
corresponding in our case to the ISS orbit period. Detailed performances of the
technique are presented in the context of the SPOrt experiment, both in terms
of added rms noise and residual correlated noise.Comment: Accepted for publication by A&A (8 pages, 6 figures
Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities.
Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with disease, but the role of this protein in disease pathogenesis is still unknown.
We characterized a Dynactin1a depletion model in the zebrafish embryo and combined in vivo molecular analysis of primary motor neuron development with live in vivo axonal transport assays in single cells to investigate ALS-related defects. To probe neuromuscular junction (NMJ) function and organization we performed paired motor neuron-muscle electrophysiological recordings and GCaMP calcium imaging in live, intact larvae, and the synapse structure was investigated by electron microscopy.
Here we show that Dynactin1a depletion is sufficient to induce defects in the development of spinal cord motor neurons and in the function of the NMJ. We observe synapse instability, impaired growth of primary motor neurons, and higher failure rates of action potentials at the NMJ. In addition, the embryos display locomotion defects consistent with NMJ dysfunction. Rescue of the observed phenotype by overexpression of wild-type human DCTN1-GFP indicates a cell-autonomous mechanism. Synaptic accumulation of DCTN1-GFP, as well as ultrastructural analysis of NMJ synapses exhibiting wider synaptic clefts, support a local role for Dynactin1a in synaptic function. Furthermore, live in vivo analysis of axonal transport and cytoskeleton dynamics in primary motor neurons show that the phenotype reported here is independent of modulation of these processes.
Our study reveals a novel role for Dynactin1 in ALS pathogenesis, where it acts cell-autonomously to promote motor neuron synapse stability independently of dynein-mediated axonal transport
Iterative destriping and photometric calibration for Planck-HFI, polarized, multi-detector map-making
We present an iterative scheme designed to recover calibrated I, Q, and U
maps from Planck-HFI data using the orbital dipole due to the satellite motion
with respect to the Solar System frame. It combines a map reconstruction, based
on a destriping technique, juxtaposed with an absolute calibration algorithm.
We evaluate systematic and statistical uncertainties incurred during both these
steps with the help of realistic, Planck-like simulations containing CMB,
foreground components and instrumental noise, and assess the accuracy of the
sky map reconstruction by considering the maps of the residuals and their
spectra. In particular, we discuss destriping residuals for polarization
sensitive detectors similar to those of Planck-HFI under different noise
hypotheses and show that these residuals are negligible (for intensity maps) or
smaller than the white noise level (for Q and U Stokes maps), for l > 50. We
also demonstrate that the combined level of residuals of this scheme remains
comparable to those of the destriping-only case except at very low l where
residuals from the calibration appear. For all the considered noise hypotheses,
the relative calibration precision is on the order of a few 10e-4, with a
systematic bias of the same order of magnitude.Comment: 18 pages, 21 figures. Match published versio
Radio emission of extensive air shower at CODALEMA: Polarization of the radio emission along the v*B vector
Cosmic rays extensive air showers (EAS) are associated with transient radio
emission, which could provide an efficient new detection method of high energy
cosmic rays, combining a calorimetric measurement with a high duty cycle. The
CODALEMA experiment, installed at the Radio Observatory in Nancay, France, is
investigating this phenomenon in the 10^17 eV region. One challenging point is
the understanding of the radio emission mechanism. A first observation
indicating a linear relation between the electric field produced and the cross
product of the shower axis with the geomagnetic field direction has been
presented (B. Revenu, this conference). We will present here other strong
evidences for this linear relationship, and some hints on its physical origin.Comment: Contribution to the 31st International Cosmic Ray Conference, Lodz,
Poland, July 2009. 4 pages, 8 figures. v2: Typo fixed, arxiv references adde
Removing 1/f noise stripes in cosmic microwave background anisotropy observations
Removal of systematic effects is crucial in present and future CMB
experiments mapping large fraction of the sky. Accurate CMB measurements ask
for multi-feed array instruments observing the sky with a redundant scanning
strategy covering the same region of the sky on different time scales and with
different detectors for a better control of systematic effects. We investigate
here the capability to suppress 1/f noise features in Time Ordered Data (TOD)
by using the destriping technique described in Maino et al. (1999), under
realistic assumptions for crossing condition between different scan circles and
sky signal fluctuations on small angular scales. We consider as working case,
Planck-LFI simulated observations with few arminutes pixel size convolved with
LFI beam resolutions. We also extend the analysis to high values of the
knee-frequency and found a residual additional noise rms ~31% larger than the
pure white noise rms at fk=1 Hz which could be a critical issue in the
extraction of the CMB angular power spectrum. Furthermore we verified that
destriping quality does not significantly depend on the receiver sensitivity
whereas it improves proportionally to the improvement of sampling rate.
Therefore given a noise level, the higher the sampling rate, the better the
destriping quality.Comment: 10 pages, 5 figures, accepted for publication on A&
Energy and Flux Measurements of Ultra-High Energy Cosmic Rays Observed During the First ANITA Flight
The first flight of the Antarctic Impulsive Transient Antenna (ANITA)
experiment recorded 16 radio signals that were emitted by cosmic-ray induced
air showers. For 14 of these events, this radiation was reflected from the ice.
The dominant contribution to the radiation from the deflection of positrons and
electrons in the geomagnetic field, which is beamed in the direction of motion
of the air shower. This radiation is reflected from the ice and subsequently
detected by the ANITA experiment at a flight altitude of 36km. In this paper,
we estimate the energy of the 14 individual events and find that the mean
energy of the cosmic-ray sample is 2.9 EeV. By simulating the ANITA flight, we
calculate its exposure for ultra-high energy cosmic rays. We estimate for the
first time the cosmic-ray flux derived only from radio observations. In
addition, we find that the Monte Carlo simulation of the ANITA data set is in
agreement with the total number of observed events and with the properties of
those events.Comment: Added more explanation of the experimental setup and textual
improvement
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