Cost-Effectiveness Evaluation of Swiss Agri-Environmental Measures on Sector Level

Abstract This paper focuses on non-linear programming models and their suitability for ex-ante evaluations of agri-environmental policies on sector level. An approach is presented to compare organic farming payments as a multi-objective policy, with other, more targeted agri-environmental policies in Switzerland. The Swiss version of the comparative static sector-consistent farm group model FARMIS is able to group the sector’s farms into organic and non-organic farms and optimise them separately. CH-FARMIS is expanded with three modules particularly for this study: a) allowing for the simulation of uptake; b) integrating life cycle assessment data for energy use, eutrophication and biodiversity; and c) estimating the policy and farm-group-specific public expenditure, including transaction costs. This paper illustrates the functions of the model, shows preliminary energy use calculations for the German Agricultural Sector and discusses the advantages and limitations of the approach

A comparison of cognitive restructuring and thought listing for excessive acquiring in hoarding disorder

Excessive acquiring is a common symptom of hoarding disorder (HD). Little is known about subjective distress associated with acquiring in HD. The present study examined acquiring- related distress and reactions to cognitive restructuring (CR) in 92 individuals with HD and 66 community control (CC) participants. All participants identified an item of interest at a high-risk acquiring location and then decided whether or not to acquire the item. HD participants completed the acquiring task while receiving a CR-based intervention or a thought-listing (TL) control condition. Results showed that HD participants reported more severe distress and greater urges to acquire the item of interest than did CC participants. Nevertheless, subjective distress decreased in both groups following the acquiring task. There were no differences in acquiring- related distress between the CR and TL conditions. The findings indicate that subjective distress may decrease after relatively short periods of time in individuals with HD, but that a single session of CR may not alleviate acquiring-related distress in HD participants.R01 MH068007 - NIMH NIH HHS; R01 MH068008 - NIMH NIH HHSAccepted manuscrip

Indoor air quality in California homes with code-required mechanical ventilation.

Data were collected in 70 detached houses built in 2011-2017 in compliance with the mechanical ventilation requirements of California's building energy efficiency standards. Each home was monitored for a 1-week period with windows closed and the central mechanical ventilation system operating. Pollutant measurements included time-resolved fine particulate matter (PM2.5 ) indoors and outdoors and formaldehyde and carbon dioxide (CO2 ) indoors. Time-integrated measurements were made for formaldehyde, NO2 , and nitrogen oxides (NOX ) indoors and outdoors. Operation of the cooktop, range hood, and other exhaust fans was continuously recorded during the monitoring period. Onetime diagnostic measurements included mechanical airflows and envelope and duct system air leakage. All homes met or were very close to meeting the ventilation requirements. On average, the dwelling unit ventilation fan moved 50% more airflow than the minimum requirement. Pollutant concentrations were similar to or lower than those reported in a 2006-2007 study of California new homes built in 2002-2005. Mean and median indoor concentrations were lower by 44% and 38% for formaldehyde and 44% and 54% for PM2.5 . Ventilation fans were operating in only 26% of homes when first visited, and the control switches in many homes did not have informative labels as required by building standards

Sub-mesoscale observations of convective cold pools with a dense station network in Hamburg, Germany

From June to August 2020, an observational network of 103 meteorological ground-based stations covered the greater area (50 km × 35 km) of Hamburg (Germany) as part of the Field Experiment on Sub-mesoscale Spatio-Temporal variability at Hanseatic city of Hamburg (FESST@HH). The purpose of the experiment was to shed light on the sub-mesoscale (O(100) m–O(10) km) structure of convective cold pools that typically remain under-resolved in operational networks. During the experiment, 82 custom-built, low-cost APOLLO (Autonomous cold POoL LOgger) stations sampled air temperature and pressure with fast-response sensors at 1 s resolution to adequately capture the strong and rapid perturbations associated with propagating cold pool fronts. A secondary network of 21 weather stations with commercial sensors provided additional information on relative humidity, wind speed, and precipitation at 10 s resolution. The realization of the experiment during the COVID-19 pandemic was facilitated by a large number of volunteers who provided measurement sites on their premises and supported station maintenance. This article introduces the novel type of autonomously operating instruments, their measurement characteristics, and the FESST@HH data set (https://doi.org/10.25592/UHHFDM.10172; Kirsch et al., 2021b). A case study demonstrates that the network is capable of mapping the horizontal structure of the temperature signal inside a cold pool, and quantifying a cold pool's size and propagation velocity throughout its life cycle. Beyond its primary purpose, the data set offers new insights into the spatial and temporal characteristics of the nocturnal urban heat island and variations of turbulent temperature fluctuations associated with different urban and natural environments

A Comparison of Cognitive Restructuring And Thought Listing For Excessive Acquiring In Hoarding Disorder

Excessive acquiring is a common symptom of hoarding disorder (HD). Little is known about subjective distress associated with acquiring in HD. The present study examined acquiring-related distress and reactions to cognitive restructuring (CR) in 92 individuals with HD and 66 community control (CC) participants. All participants identified an item of interest at a high-risk acquiring location and then decided whether or not to acquire the item. HD participants completed the acquiring task while receiving a CR-based intervention or a thought-listing (TL) control condition. Results showed that HD participants reported more severe distress and greater urges to acquire the item of interest than did CC participants. Nevertheless, subjective distress decreased in both groups following the acquiring task. There were no differences in acquiring-related distress between the CR and TL conditions. The findings indicate that subjective distress may decrease after relatively short periods of time in individuals with HD, but that a single session of CR may not alleviate acquiring-related distress in HD participants

Early CT and FDG-metabolic tumour volume changes show a significant correlation with survival in stage I-III small cell lung cancer: A hypothesis generating study

BACKGROUND: Many patients with stage I–III small cell lung cancer (SCLC) experience disease progression short after the completion of concurrent chemoradiotherapy (CRT). The purpose of the current study was to evaluate whether CT or FDG metabolic response early after the start of chemotherapy, but before the beginning of chest RT, is predictive for survival in SCLC. METHODS: Fifteen stage I–III SCLC patients treated with concurrent CRT with an FDG-PET and CT scan available before the start of chemotherapy and after or during the first cycle of chemotherapy, but before the start of radiotherapy, were selected. The metabolic volume (MV) was defined both within the primary tumour and in the involved nodal stations using the 40% (MV40) and 50% (MV50) threshold of the maximum SUV. Metabolic and CT response was assessed by the relative change in MV and CT volume, respectively, between both time points. The association between response and overall survival (OS) was analysed by univariate cox regression analysis. The minimum follow-up was 18 months. RESULTS: Reductions in MV40 and MV50 were −36 ± 38% (126.4 to 68.7 cm(3)) and −44 ± 38% (90.2 to 27.8 cm(3)), respectively. The median CT volume reduction was −40 ± 64% (190.6 to 113.8 cm(3)). MV40 and MV50 changes showed a significant association with survival (HR = 1.02, 95% CI: 1.00–1.04 (p = 0.042); HR = 1.02, 95% CI: 1.00–1.04 (p = 0.048), respectively), indicating a 2% increase in survival probability for 1% reduction in metabolic volume. The CT volume change was also significantly correlated with survival (HR = 1.01, 95% CI: 1.00–1.03, p = 0.007). CONCLUSIONS: This hypothesis generating study shows that both the early CT and the MV changes show a significant correlation with survival in SCLC. A prospective study is planned in a larger patient cohort to allow multivariate analysis, with the final aim to select patients early during treatment that could benefit from dose intensification or alternative treatment

Photothermal infrared thermography applied to the identification of thin layer thermophysical properties

Abstract: The aim of the present work is the thermal non-destructive characterisation of layers at the surface of metals. The sample is sinusoidally heated by means of an argon ion laser and a focal plane array infrared camera (CEDIP IRC 320-4 LW) is used to measure the temperature variations at the surface of the layer. A numerical lock-in procedure allows the detection of very weak temperature variations at the surface of the sample, down to a few mK when working from the acquisition of hundreds of images, yielding amplitude and absolute phase maps for modulation frequencies ranging from 0.1 Hz to 1000 Hz. An inverse procedure uses the Gauss-Newton parameter estimation method, in order to identify the thermal conductivity and the optical absorption coefficient of the layer. Confidence intervals on the parameters can also be estimated by the inverse procedure. More particular attention is devoted to the study of the sensitivity coefficients, as functions of the frequency range and of the radial range along the profiles, in order to optimise the identification procedure

Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma

Background: The approval of immune checkpoint inhibitors in combination with specific diagnostic biomarkers presents new challenges to pathologists as tumor tissue needs to be tested for expression of programmed death-ligand 1 (PD-L1) for a variety of indications. As there is currently no requirement to use companion diagnostic assays for PD-L1 testing in Germany different clones are used in daily routine. While the correlation of staining results has been tested in various entities, there is no data for head and neck squamous cell carcinomas (HNSCC) so far. Methods: We tested five different PD-L1 clones (SP263, SP142, E1L3N, 22-8, 22C3) on primary HNSCC tumor tissue of 75 patients in the form of tissue microarrays. Stainings of both immune and tumor cells were then assessed and quantified by pathologists to simulate real-world routine diagnostics. The results were analyzed descriptively and the resulting staining pattern across patients was further investigated by principal component analysis and non-negative matrix factorization clustering. Results: Percentages of positive immune and tumor cells varied greatly. Both the resulting combined positive score as well as the eligibility for certain checkpoint inhibitor regimens was therefore strongly dependent on the choice of the antibody. No relevant co-clustering and low similarity of relative staining patterns across patients was found for the different antibodies. Conclusions: Performance of different diagnostic anti PD-L1 antibody clones in HNSCC is less robust and interchangeable compared to reported data from other tumor entities. Determination of PD-L1 expression is critical for therapeutic decision making and may be aided by back-to-back testing of different PD-L1 clones

Consistent alpha-cluster description of the 12C (0^+_2) resonance

The near-threshold 12C (0^+_2) resonance provides unique possibility for fast helium burning in stars, as predicted by Hoyle to explain the observed abundance of elements in the Universe. Properties of this resonance are calculated within the framework of the alpha-cluster model whose two-body and three-body effective potentials are tuned to describe the alpha - alpha scattering data, the energies of the 0^+_1 and 0^+_2 states, and the 0^+_1-state root-mean-square radius. The extremely small width of the 0^+_2 state, the 0_2^+ to 0_1^+ monopole transition matrix element, and transition radius are found in remarkable agreement with the experimental data. The 0^+_2-state structure is described as a system of three alpha-particles oscillating between the ground-state-like configuration and the elongated chain configuration whose probability exceeds 0.9