Demystifying progressive design build: implementation issues and lessons learned through case study analysis

The design–build (DB) project delivery method has been used for several decades in the US construction market. DB contracts are usually awarded on the basis of a multicriteria evaluation, with price as one of the most salient criteria. To ensure the project’s success, an owner usually has to invest enough time and effort during scoping and early design to define a program, scope, and budget, ready for procurement and price generation. However, this process can become a burden for the owner and may lengthen the project development duration. As an alternative to the traditional DB, the progressive design–build (PDB) approach permits the selection of the DB team prior to defining the project program and/ or budget. PDB has the advantage of maintaining a single point of accountability and allowing team selection based mainly on qualifications, with a limited consideration of price. Under PDB, the selected team works with the project stakeholders during the early design stage, while helping the owner balance scope and budget. However, the key to the effectiveness of PDB is its provision for the ongoing and complete involvement of the owner in the early design phase. Due to the differences between PDB and the other project delivery methods (e.g., traditional DB), project teams must carefully consider several factors to ensure its successful implementation. The research team conducted a case study of the University of Washington’s pilot PDB project to complete the West Campus Utility Plant (WCUP). This paper carefully explores and summarizes the project’s entire delivery process (e.g., planning, solicitation, design, and construction), its organizational structures, and the project performance outcomes. The lessons learned from the WCUP project will contribute to best practices for future PDB implementation

Planning for strategic change in the project delivery strategy

For organizations such as state departments of transportation, other public agencies, or private companies, adopting a new approach to procure services for delivery of construction projects requires significant organizational changes; modifications to both their work processes and existing organizational structures may be needed. These adjustments, encompassing many different aspects of the organization's interests, must occur for the change initiative to be successfully put into practice. In this research, the adoption of integrated project delivery methods within the transportation project sector is investigated to better understand the dynamics of this change. In the context of this study, an Owner's project delivery strategy is defined as the set of project delivery methods that are adopted for delivering capital projects. This dissertation presents findings from a study of Public Owner organizations that have implemented the designbuild method for delivering highway projects. Using as a case study the new $1.3 billion SH-130 tolled expressway project in Central Texas, the author analyzed project documentation and conducted many interviews with individuals affiliated with owner, legal, engineering consultants, and contractors. Findings suggest that project representatives institutionalize practices and routines connected to the new approach by adapting to new challenges, rather than "overwriting" previously existing practices. Similarly, the institutionalization of innovative approaches to project delivery happens concurrently with a deinstitutionalization of the previous approaches. Building upon these findings, a conceptual framework is presented for helping Owner organizations implement change in their project delivery strategy. The proposed conceptual framework is based upon both existing published literature and interviews with managers involved in implementing a strategic change in project delivery strategy. This framework was further refined by making a comparative study of four transportation projects in the United States. In addition, a detailed implementation framework was validated and further developed through a Delphi study with representatives from several organizations whose major responsibilities and experiences include the management of change in procurement approach. Findings from these studies, including application to the construction industry and other industries are presented.Civil, Architectural, and Environmental Engineerin

An Inexpensive 6D Motion Tracking System for Posturography

Computerized posturography is most often performed with a force plate measuring center-of-pressure (COP). COP is related to postural control actions but does not monitor the outcome of those actions, i.e., center-of-mass (COM) stability. For a more complete analysis of postural control COM should also be measured; however, existing motion tracking technology is prohibitively expensive and overcomplicated for routine use. The objective of this work was to create and validate an inexpensive and convenient stereo vision system which measured a trunk-fixed target's 3D position and orientation relating to COM. The stereo vision system would be complementary to typical force plate methods providing precise 6D position measurements under laboratory conditions. The developed system's measurement accuracy was worst in the inferior-superior axis (depth) and pitch coordinates with accuracy measures 1.1 mm and 0.8°, respectively. The system's precision was worst in the depth and roll coordinates with values 0.1 mm and 0.15°, respectively. Computer modeling successfully predicted this precision with 11.3% mean error. Correlation between in vivo target position (TP) and COP was above 0.73 with COP generally demonstrating larger excursions oscillating around TP. Power spectral analysis of TP revealed 99% of the signal was bound below 1.1 Hz matching expectations for COM. The new complementary measurement method enables identification of postural control strategies and as a result more complete analysis. Stereo vision is a useful complement to typical force plate equipment. The system presented here is inexpensive and convenient demonstrating potential for routine use in clinic and research. In order to use this system in clinic, future work is required in interpretation of this system's data and normal reference values must be established across gender and age in a healthy population followed by values from patients with different pathologies

Comparing Performance of Construction Projects Delivered through Different Delivery Methods

When new delivery methods are introduced in public procurement, it is customary to analyze and compare their performance against traditional methods. Many early studies compared performance of different project delivery systems, and often developed decision support tools to help owners follow a structured path in measuring performance and, consequently, choose the most appropriate project delivery method. However, the measurement process adopted by these studies was mostly specific to the dataset to be analyzed. Only rarely, it took into account differences deriving from varying project characteristics, and, therefore was not generalizable. Building upon these studies, this study proposes a general framework for comparing performance of projects delivered through different delivery methods. A discussion of how the framework could also be adapted to every industry sector is included. This work can help owners choose a set of metrics to evaluate and compare the performance of project portfolios delivered with more than one delivery method and different industry secto

Novel strategies for the treatment of myelofibrosis driven by recent advances in understanding the role of the microenvironment in its etiology

Myelofibrosis is the advanced stage of the Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), characterized by systemic inflammation, hematopoietic failure in the bone marrow, and development of extramedullary hematopoiesis, mainly in the spleen. The only potentially curative therapy for this disease is hematopoietic stem cell transplantation, an option that may be offered only to those patients with a compatible donor and with an age and functional status that may face its toxicity. By contrast, with the Philadelphia-positive MPNs that can be dramatically modified by inhibitors of the novel BCR-ABL fusion-protein generated by its genetic lesion, the identification of the molecular lesions that lead to the development of myelofibrosis has not yet translated into a treatment that can modify the natural history of the disease. Therefore, the cure of myelofibrosis remains an unmet clinical need. However, the excitement raised by the discovery of the genetic lesions has inspired additional studies aimed at elucidating the mechanisms driving these neoplasms towards their final stage. These studies have generated the feeling that the cure of myelofibrosis will require targeting both the malignant stem cell clone and its supportive microenvironment. We will summarize here some of the biochemical alterations recently identified in MPNs and the novel therapeutic approaches currently under investigation inspired by these discoveries

On the Trade-Off Between Enhancement of the Spatial Resolution and Noise Amplification in Conical-Scanning Microwave Radiometers

The ability to enhance the spatial resolution of measurements collected by a conical-scanning microwave radiometer (MWR) is discussed in terms of noise amplification and improvement of the spatial resolution. Simulated (and actual) brightness temperature profiles are analyzed at variance of different intrinsic spatial resolutions and adjacent beams overlapping modeling a simplified 1-D measurement configuration (MC). The actual measurements refer to Special Sensor Microwave Imager (SSM/I) data collected using the 19.35 and the 37.00 GHz channels that match the simulated configurations. The reconstruction of the brightness profile at enhanced spatial resolution is performed using an iterative gradient method which allows a fine tuning of the level of regularization. Objective metrics are introduced to quantify the enhancement of the spatial resolution and noise amplification. Numerical experiments, performed using the simplified 1-D MC, show that the regularized deconvolution results in negligible advantages when dealing with low-overlapping/fine-spatial-resolution configurations. Regularization is a mandatory step when addressing the high-overlapping/low-spatial-resolution case and the spatial resolution can be enhanced up to 2.34 with a noise amplification equal to 1.56. A more stringent requirement on the noise amplification (up to 0.6) results in an improvement of the spatial resolution up to 1.64

Dynamic factor analysis of surface water management impacts on soil and bedrock water contents in Southern Florida Lowlands

As part of the C111 spreader canal project, structural and operational modifications involving incremental raises in canal stage are planned along one of the major canals (i.e., C111) separating Everglades National Park and agricultural production areas to the east of the park. This study used Dynamic Factor Analysis (DFA) as an alternative tool to physically based models to explore the relationship between different hydrologic variables and the effect of proposed changes in surface water management on soil and bedrock water contents in south Florida. To achieve the goal, objectives were to: (1) use DFA to identify the most important factors affecting temporal variation in soil and bedrock water contents, (2) develop a simplified DFA based regression model for predicting soil and bedrock water contents as a function of canal stage and (3) assess the effect of the proposed incremental raises in canal stage on soil and bedrock water contents. DFA revealed that 5 common trends were the minimum required to describe unexplained variation in the 11 time series studied. Introducing canal stage, water table evaporation and net recharge resulted in lower Akaike information criterion (AIC) and higher Nash-Sutcliffe (C[subscript eff]) values. Results indicated that canal stage significantly (t > 2) drives temporal variation in soil and bedrock water contents, which was represented as scaled frequency while net surface recharge was significant in 7 out of the 11 time series analyzed. The effect of water table evaporation was not significant at all sites. Results also indicated that the most important factor influencing temporal variation in soil and bedrock water contents in terms of regression coefficient magnitude was canal stage. Based on DFA results, a simple regression model was developed to predict soil and bedrock water contents at various elevations as a function of canal stage and net recharge. The performance of the simple model ranged from good (C[subscript eff] ranging from 0.56 to 0.74) to poor (C[subscript eff] ranging from 0.10 to 0.15), performance was better at sites with smaller depths to water table (< 1 m) highlighting the effect of micro-topography on soil and bedrock water content dynamics. Assessment of the effect of 6, 9 and 12 cm increases in canal stage using the simple regression model indicated that changes in temporal variation in soil and bedrock water contents were negligible (average<1.0% average change) at 500 to 2000 m from C111 (or low elevations) which may be attributed to the near saturation conditions already occurring at these sites. This study used DFA to explore the relationship between soil and bedrock water dynamics and surface water stage in shallow water table environments. This approach can be applied to any system in which detailed physical modeling would be limited by inadequate information on parameters or processes governing the physical system

MicroRNA modulation by dietary supplements in obesity

The prevalence of obesity has dramatically increased over the last decades. Weight loss obtained through diet and exercise leads to a significant decrease in morbidity and mortality. Recently, there has been growing interest in the possible beneficial effects of dietary supplements (DSs), including polyphenols, fatty acids, and other plant-derived substances, as adjuvants in the management of obesity and metabolic diseases. Specifically, polyphenols, widely spread in vegetables and fruits, significantly modulate adipose tissue activities, contrasting inflammation and improving insulin sensitivity in preclinical and clinical studies. Remarkably, polyphenols are involved in complex microRNA networks, which play crucial roles in metabolic processes. The administration of different polyphenols and other plant-derived compounds led to significant changes in the microRNA expression profile in peripheral tissues in a growing number of preclinical studies. In particular, these compounds were able to revert obesity-induced microRNA dysregulation, leading to the inhibition of adipogenesis and the induction of weight loss. Furthermore, through microRNA modulation, they attenuated key metabolic alterations, including insulin resistance and lipid anomalies, in animal models of obesity. Some of them were also able to reduce proinflammatory cytokines in adipose tissue. The aim of this review is to summarize current evidence about the effect of plant-derived DSs on microRNA expression in obesity

Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity.

Obesity is a multifactorial disease linked to metabolic chronic disorders such as diabetes, and hypertension. Also, it has recently been associated with skeletal alterations and low bone mineral density. We previously demonstrated that exposure of osteoblasts to sera of sedentary subjects affected by obesity alters cell homeostasis in vitro, leading to disruption of intracellular differentiation pathways and cellular activity. Thus, the purpose of the present study has been to evaluate whether sera of sedentary obese women, subjected to physical activity and hypocaloric diet, could recover osteoblast homeostasis in vitro as compared to the sera of same patients before intervention protocol. To this aim, obese women were evaluated at time 0 and after 4, 6, and 12 months of individualized prescribed physical activity and hypocaloric diet. Dual-energy-X-ray absorptiometry measurements were performed at each time point, as well as blood was collected at the same points. Cells were incubated with sera of subjects before and after physical activity as described: obese at baseline and after for 4, 6, and 12 months of physical activity and nutritional protocol intervention. Osteoblasts exposed to sera of patients, who displayed increased lean and decreased fat mass (from 55.5 ± 6.5 to 57.1 ± 5.6% p ≤ 0.05; from 44.5 ± 1.1 to 40.9 ± 2.6% p ≤ 0.01 respectively), showed a time-dependent increase of Wnt/β-catenin signaling, versus cells exposed to sera of obese patients before intervention protocol, suggesting recovery of osteoblast homeostasis upon improvement of body composition. An increase in β-catenin nuclear accumulation and nuclear translocation was also observed, accompanied by an increase in Adiponectin receptor 1 protein expression, suggesting positive effect on cell differentiation program. Furthermore, a decrease in sclerostin amount and an increase of type 1 procollagen amino-terminal-propeptide were depicted as compared to baseline, proportionally to the time of physical activity, suggesting a recovery of bone remodeling modulation and an increase of osteoblast activity induced by improvement of body composition. In conclusion, our results show for the first time that sera of obese sedentary women who increased lean mass and decreased fat mass, by physical activity and hypocaloric diet, rescue osteoblasts differentiation and activity likely due to a reactivation of Wnt/β-catenin-pathway, suggesting that a correct life style can improve skeletal metabolic alteration induced by obesity