63 research outputs found
Efecto de la densidad en cebo sobre el rendimiento productivo, la composición de la carne y el perfil de ácidos grasos de cerdos sacrificados con 110 kg de peso
El número de cerdos por cuadra y la densidad influyen sobre el rendimiento productivo
(Edmons et al., 1998). Además, la densidad de cría puede afectar a la calidad de la canal y
de la carne (Estevez et al., 2003), ya que una reducción del espacio disponible da lugar a
peleas y mordeduras de colas. Sin embargo, la producción de carne por m
2
aumenta con la
densidad con un mejor aprovechamiento de la superficie disponible. Por otro lado, la
densidad podría afectar de distinto modo a hembras (HE) y a machos castrados (MC)
debido posiblemente al menor consumo voluntario de pienso de las HE. A este particular,
Hamilton et al. (2003) observaron que a altas densidades de cría las HE fueron
relativamente más magras mientras que los MC eran relativamente más grasos. Cambios en
la densidad de cría, pueden afectar a la composición en ácidos grasos de la canal debido a
cambios en el consumo y a la utilización del alimento (Nürnberg et al., 1998). El objetivo de
este estudio fue comparar el efecto de la densidad de cebo de HE y MC con alto potencial
de crecimiento, sobre el rendimiento productivo y la composición de la carne y el perfil de
ácidos grasos en cerdos de 19 a 109 kg PV
Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes
The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases
Genetic analysis of the naked trait in panicles of hexaploid oat
The aim of this study was to estimate the number of genes that control the naked (hull-less) trait and the mode of expression
of this characteristic in panicles of hexaploid white oat. Parents and the segregating population (in the F2
and F3
generations) were
evaluated in regard to the presence and distribution of naked grains in panicles of individual oat plants. For each plant, a drawing
of the main panicle was developed. From the drawings obtained in the progenies of the F2
population, six distinct phenotypic classes
were produced. The expected phenotypic proportion of 3:9:4 (naked:segregating:hulled) was that which best fit by the Chi-square test.
In the F3
generation, the results showed agreement with the hypothesis observed in the F2
generation. The naked trait in oat is passed
on by two genes and the greatest expression of this trait occurs in the upper third of the panicles. Expression of this trait in oats is not
complete, even in homozygous genotypes
Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study
Rationale: The triple-combination regimen elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis and at least one F508del-CFTR allele in a phase 3, open-label, single-arm study. Objectives: To further evaluate the efficacy and safety of ELX/TEZ/IVA in children 6 through 11 years of age with cystic fibrosis heterozygous for F508del and a minimal function CFTR mutation (F/MF genotypes) in a randomized, double-blind, placebo-controlled phase 3b trial. Methods: Children were randomized to receive either ELX/TEZ/IVA (n = 60) or placebo (n = 61) during a 24-week treatment period. The dose of ELX/TEZ/IVA administered was based on weight at screening, with children <30 kg receiving ELX 100 mg once daily, TEZ 50 mg once daily, and IVA 75 mg every 12 hours, and children ⩾30 kg receiving ELX 200 mg once daily, TEZ 100 mg once daily, and IVA 150 mg every 12 hours (adult dose). Measurements and Main Results: The primary endpoint was absolute change in lung clearance index2.5 from baseline through Week 24. Children given ELX/TEZ/IVA had a mean decrease in lung clearance index2.5 of 2.29 units (95% confidence interval [CI], 1.97-2.60) compared with 0.02 units (95% CI, -0.29 to 0.34) in children given placebo (between-group treatment difference, -2.26 units; 95% CI, -2.71 to -1.81; P < 0.0001). ELX/TEZ/IVA treatment also led to improvements in the secondary endpoint of sweat chloride concentration (between-group treatment difference, -51.2 mmol/L; 95% CI, -55.3 to -47.1) and in the other endpoints of percent predicted FEV1 (between-group treatment difference, 11.0 percentage points; 95% CI, 6.9-15.1) and Cystic Fibrosis Questionnaire-Revised Respiratory domain score (between-group treatment difference, 5.5 points; 95% CI, 1.0-10.0) compared with placebo from baseline through Week 24. The most common adverse events in children receiving ELX/TEZ/IVA were headache and cough (30.0% and 23.3%, respectively); most adverse events were mild or moderate in severity. Conclusions: In this first randomized, controlled study of a cystic fibrosis transmembrane conductance regulator modulator conducted in children 6 through 11 years of age with F/MF genotypes, ELX/TEZ/IVA treatment led to significant improvements in lung function, as well as robust improvements in respiratory symptoms and cystic fibrosis transmembrane conductance regulator function. ELX/TEZ/IVA was generally safe and well tolerated in this pediatric population with no new safety findings.
Keywords: children; cystic fibrosis; elexacaftor; ivacaftor; tezacaftor
Rosemary extract and celery-based products used as natural quality enhancers for colonial type salami with different ripening times
Performance and carcass characteristics of swine at 50 kg fed diets with different energy levels and reduced levels of crude protein
Óleos essenciais como substituintes de antibióticos promotores de crescimento em frangos de corte: perfil de soroproteínas e peroxidação lipídica
Partial replacement of poly- with monounsaturated fatty acids and vitamin E supplementation in pig diets: effect on fatty acid composition of subcutaneous and intramuscular fat and on fat and lean firmness
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