10,628 research outputs found

    Kolmogorov-Smirnov method for the determination of signal time-shifts

    Full text link
    A new method for the determination of electric signal time-shifts is introduced. As the Kolmogorov-Smirnov test, it is based on the comparison of the cumulative distribution functions of the reference signal with the test signal. This method is very fast and thus well suited for on-line applications. It is robust to noise and its performances in terms of precision are excellent for time-shifts ranging from a fraction to several sample durations. PACS. 29.40.Gx (Tracking and position-sensitive detectors), 29.30.Kv (X- and -ray spectroscopy), 07.50.Qx (Signal processing electronics)Comment: 8 pages, 7 figure

    Fast analytical methods for the correction of signal random time-shifts and application to segmented HPGe detectors

    Full text link
    Detection systems rely more and more on on-line or off-line comparison of detected signals with basis signals in order to determine the characteristics of the impinging particles. Unfortunately, these comparisons are very sensitive to the random time shifts that may alter the signal delivered by the detectors. We present two fast algebraic methods to determine the value of the time shift and to enhance the reliability of the comparison to the basis signals.Comment: 13 pages, 8 figure

    Π‘ΠΊΡ€ΠΈΠ½ΠΈΠ½Π³ экстрактов лСкарствСнных растСний Π²ΠΎ Π’ΡŒΠ΅Ρ‚Π½Π°ΠΌΠ΅ ΠΈ исслСдованиС ΠΈΡ… ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Ρ†ΠΈΠΈ для ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ ΠΈ лСчСния ΠΏΠΎΠ΄Π°Π³Ρ€Ρ‹

    Get PDF
    Objectives. The study aimed to examine the potential use of ethanol extracts of four medicinal plants to prevent and treat gout disease.Methods. An investigation of some typical compound contents such as polyphenols, flavonoids, and tannins in terms of two bioactive abilities, including anti-xanthine oxidase and antioxidant was carried out in Eclipta prostrata L., Artemisia vulgaris L., Apium graveolens L., and Piper betle L samples. Subsequently, the weight ratios of Piper betle L. and Artemisia vulgaris L. were investigated to reduce the total tannin content and get the most suitable anti-xanthine oxidase activity.Results. As well as having the highest target compound contents, Piper betle L. demonstrated the best anti-xanthine oxidase and antioxidant abilities even while its IC50 values were lower than positive control; however, its high total tannin content can cause some side effects. A mixture with a weight ratio of 1:1 of Piper betle L. and Artemisia vulgaris L. had a total tannin content half that of Piper betle L. as well as demonstrating potential anti-xanthine oxidase and antioxidant activities when IC50 was about 3.94 and 20.85 Β΅g/mL, respectively.Conclusions. Out of the four selected plants, Piper betle L. demonstrated the best potential material for preventing and treating gout disease. However, due to the high tannin content in it, a mix of Piper betle L. and Artemisia vulgaris L. at a weight ratio of 1:1 gave optimal results for application in treatment.Π¦Π΅Π»ΠΈ. Π˜Π·ΡƒΡ‡ΠΈΡ‚ΡŒ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ΅ использованиС ΡΡ‚Π°Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… экстрактов Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅Ρ… лСкарствСнных растСний для ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ ΠΈ лСчСния ΠΏΠΎΠ΄Π°Π³Ρ€Ρ‹.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠ±Ρ€Π°Π·Ρ†Ρ‹ эклипты простёртой (Eclipta prostrata L.), ΠΏΠΎΠ»Ρ‹Π½ΠΈ ΠΎΠ±Ρ‹ΠΊΠ½ΠΎΠ²Π΅Π½Π½ΠΎΠΉ (Artemisia vulgaris L.), ΡΠ΅Π»ΡŒΠ΄Π΅Ρ€Π΅Ρ ΠΏΠ°Ρ…ΡƒΡ‡Π΅Π³ΠΎ (Apium graveolens L.) ΠΈ ΠΏΠ΅Ρ€Ρ†Π° Π±Π΅Ρ‚Π΅Π»ΡŒ (Piper betle L. ) исслСдовались с Ρ‚ΠΎΡ‡ΠΊΠΈ зрСния содСрТания Π² Π½ΠΈΡ… ΠΏΠΎΠ»ΠΈΡ„Π΅Π½ΠΎΠ»ΠΎΠ², Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² ΠΈ Π΄ΡƒΠ±ΠΈΠ»ΡŒΠ½Ρ‹Ρ… вСщСств, Π° Ρ‚Π°ΠΊΠΆΠ΅ наличия биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… свойств, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ Π°Π½Ρ‚ΠΈΠΊΡΠ°Π½Ρ‚ΠΈΠ½ΠΎΠΊΡΠΈΠ΄Π°Π·Π½ΡƒΡŽ ΠΈ Π°Π½Ρ‚ΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ‚Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ. Π”Π°Π»Π΅Π΅ Π±Ρ‹Π»ΠΈ Π½Π°ΠΉΠ΄Π΅Π½Ρ‹ вСсовыС ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ Piper betle L. ΠΈ Artemisia vulgaris L., ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΠ΅ ΡΠ½ΠΈΠ·ΠΈΡ‚ΡŒ ΠΎΠ±Ρ‰Π΅Π΅ содСрТаниС Ρ‚Π°Π½ΠΈΠ½Π° ΠΈ ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΡΡ‰ΡƒΡŽ Π°Π½Ρ‚ΠΈΠΊΡΠ°Π½Ρ‚ΠΈΠ½ΠΎΠΊΡΠΈΠ΄Π°Π·Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Помимо самого высокого содСрТания Ρ†Π΅Π»Π΅Π²ΠΎΠ³ΠΎ соСдинСния, Piper betle L. продСмонстрировал Π½Π°ΠΈΠ»ΡƒΡ‡ΡˆΠΈΠ΅ антиксантиноксидазныС ΠΈ антиоксидантныС свойства, Π΄Π°ΠΆΠ΅ нСсмотря Π½Π° Ρ‚ΠΎ, Ρ‡Ρ‚ΠΎ Π΅Π³ΠΎ значСния IC50 Π±Ρ‹Π»ΠΈ Π½ΠΈΠΆΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ контроля. Однако высокоС содСрТаниС ΠΎΠ±Ρ‰Π΅Π³ΠΎ Ρ‚Π°Π½ΠΈΠ½Π° Π² Π½Π΅ΠΌ ΠΌΠΎΠΆΠ΅Ρ‚ Π²Ρ‹Π·Ρ‹Π²Π°Ρ‚ΡŒ Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΠΎΠ±ΠΎΡ‡Π½Ρ‹Π΅ эффСкты. БмСсь Piper betle L. ΠΈ Artemisia vulgaris L. с массовым ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ΠΌ 1:1 ΠΈΠΌΠ΅Π»Π° ΠΎΠ±Ρ‰Π΅Π΅ содСрТаниС Ρ‚Π°Π½ΠΈΠ½Π° Π²Π΄Π²ΠΎΠ΅ мСньшС, Ρ‡Π΅ΠΌ Piper betle L., Π° Ρ‚Π°ΠΊΠΆΠ΅ дСмонстрировала ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΡƒΡŽ Π°Π½Ρ‚ΠΈΠΊΡΠ°Π½Ρ‚ΠΈΠ½ΠΎΠΊΡΠΈΠ΄Π°Π·Π½ΡƒΡŽ ΠΈ Π°Π½Ρ‚ΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ‚Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, ΠΏΡ€ΠΈ этом IC50 составлял ΠΎΠΊΠΎΠ»ΠΎ 3.94 ΠΈ 20.85 ΠΌΠΊΠ³/ΠΌΠ» соотвСтствСнно.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Из Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅Ρ… ΠΎΡ‚ΠΎΠ±Ρ€Π°Π½Π½Ρ‹Ρ… растСний Piper betle L. являСтся Π½Π°ΠΈΠ»ΡƒΡ‡ΡˆΠΈΠΌ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΌ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠΌ для ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ ΠΈ лСчСния ΠΏΠΎΠ΄Π°Π³Ρ€Ρ‹. Однако ΠΈΠ·-Π·Π° высокого содСрТания Π² Π½Π΅ΠΌ Ρ‚Π°Π½ΠΈΠ½Π° смСсь Piper betle L. ΠΈ Artemisia vulgaris L. Π² ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ ΠΏΠΎ массС 1:1 Π΄Π°Π»Π° ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ для примСнСния Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ

    Absorbing boundary conditions for the Westervelt equation

    Full text link
    The focus of this work is on the construction of a family of nonlinear absorbing boundary conditions for the Westervelt equation in one and two space dimensions. The principal ingredient used in the design of such conditions is pseudo-differential calculus. This approach enables to develop high order boundary conditions in a consistent way which are typically more accurate than their low order analogs. Under the hypothesis of small initial data, we establish local well-posedness for the Westervelt equation with the absorbing boundary conditions. The performed numerical experiments illustrate the efficiency of the proposed boundary conditions for different regimes of wave propagation

    The High-Superior-Tension Technique: Evolution of Lipoabdominoplasty

    Get PDF
    Because abdominoplasty is associated with complications such as seroma and necrosis as well as epigastric bulging and a suprapubic scar located too high, the demand for this procedure is not as high as it otherwise might be. However, although these negative effects were common many years ago, their incidence has decreased dramatically with modern abdominoplastic techniques. One approach using a combination of abdominoplasty and liposuction or lipoabdominoplasty has resolved many of the problems faced with earlier techniques, offering aesthetically pleasing results and excellent reliability. The keys to successful lipoabdominoplasty, first developed as the high-superior-tension technique, are extensive liposuction, preservation of lymphatic trunks, preaponeurotic epigastric dissection, major muscle fascia plication, two high-tension paraumbilical sutures, hypogastric tension sutures, and closure of the dead spaces. The most recent updates to this technique are described in this article

    Design Principles for Plasmonic Nanoparticle Devices

    Get PDF
    For all applications of plasmonics to technology it is required to tailor the resonance to the optical system in question. This chapter gives an understanding of the design considerations for nanoparticles needed to tune the resonance. First the basic concepts of plasmonics are reviewed with a focus on the physics of nanoparticles. An introduction to the finite element method is given with emphasis on the suitability of the method to nanoplasmonic device simulation. The effects of nanoparticle shape on the spectral position and lineshape of the plasmonic resonance are discussed including retardation and surface curvature effects. The most technologically important plasmonic materials are assessed for device applicability and the importance of substrates in light scattering is explained. Finally the application of plasmonic nanoparticles to photovoltaic devices is discussed.Comment: 29 pages, 15 figures, part of an edited book: "Linear and Non-Linear Nanoplasmonics

    Π‘ΠΊΡ€ΠΈΠ½ΠΈΠ½Π³ экстрактов лСкарствСнных растСний Π½Π° ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΡƒΡŽΡ‰ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ксантиноксидазы

    Get PDF
    Objectives. The study aimed to test the ethanol extracts of ten medicinal plants for xanthine oxidase inhibitory activity.Methods. The degree of xanthine oxidase inhibitory activity was determined by measuring the absorbance spectrophotometrically at 290 nm, which is associated with uric acid formation. The selected medicinal plants included Piper lolot C.DC. (Piperaceae), Pandanus amaryllifolius R.(Pandanaceae), Brassica juncea L. (Brassicaceae), Piper betle L. (Piperaceae), Perilla frutescens L. (Lamiaceae), Anacardium occidentale L. (Anacardiaceae), Polygonum barbatum L. (Polygonaceae), Artocarpus Altilis P. (Moraceae), Vitex negundo L. (Verbenaceae), Annona squamosal L. (Annonaceae), which were selected based on folk medicine.Results. The results showed that the Piper betle L. has a strong ability to inhibit xanthine oxidase with an IC50 value of up to 1.18 ΞΌg/mL, compared to allopurinol 1.57 ΞΌg/mL. Different parts of Piper betle L. were compared and the leaves of Piper betle L. showed the best value for xanthine oxidase inhibitory and antioxidant activity.Conclusions. Piper betle L. showed the best potential for inhibition of xanthine oxidase among ten medicinal plants. Piper betle L. leaf extract showed strong xanthine oxidase inhibitory and antioxidant activity, compared to the whole plant, and the stem extract, which promises to be applied in the treatment of gout.Π¦Π΅Π»ΠΈ. ИсслСдованиС Π±Ρ‹Π»ΠΎ Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΎ Π½Π° ΠΏΡ€ΠΎΠ²Π΅Ρ€ΠΊΡƒ ΡΡ‚Π°Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… экстрактов дСсяти лСкарствСнных растСний Π½Π° ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ксантиноксид Π°Π·Ρ‹.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π‘Ρ‚Π΅ΠΏΠ΅Π½ΡŒ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉ активности ксантиноксидазы опрСдСляли ΠΏΡƒΡ‚Π΅ΠΌ спСктрофотомСтричСского измСрСния поглощСния ΠΏΡ€ΠΈ 290 Π½ΠΌ, Π²Ρ‹Π·Ρ‹Π²Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΎΡ‡Π΅Π²ΠΎΠΉ кислоты. Π’ состав ΠΎΡ‚ΠΎΠ±Ρ€Π°Π½Π½Ρ‹Ρ… лСкарствСнных растСний вошли ΠΏΠ΅Ρ€Π΅Ρ†-Π»ΠΎΠ»ΠΎΡ‚ (Piperaceae), ΠΏΠ°Π½Π΄Π°Π½ (Pandanaceae), Π³ΠΎΡ€Ρ‡ΠΈΡ†Π° сарСптская (Brassicaceae), Π±Π΅Ρ‚Π΅Π»ΡŒ (Piperaceae), ΠΏΠ΅Ρ€ΠΈΠ»Π»Π° обыкновСнная (Lamiaceae), кСшью (Anacardiaceae), конопля (Polygonaceae), Ρ…Π»Π΅Π±Π½ΠΎΠ΅ Π΄Π΅Ρ€Π΅Π²ΠΎ (Moraceae), прутняк китайский (Verbenaceae), сахарноС яблоко (Annonaceae), ΠΎΡ‚ΠΎΠ±Ρ€Π°Π½Π½Ρ‹Π΅ Π½Π° основС ΠΈΡ… примСнСния Π² Π½Π°Ρ€ΠΎΠ΄ Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, Ρ‡Ρ‚ΠΎ Π±Π΅Ρ‚Π΅Π»ΡŒ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ сильной ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒΡŽ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ксантиноксидазу со Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ΠΌ IC50 Π΄ΠΎ 1.18 ΠΌΠΊΠ³/ΠΌΠ» ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с Π°Π»Π»ΠΎΠΏΡƒΡ€ΠΈΠ½ΠΎΠ»ΠΎΠΌ 1.57 ΠΌΠΊΠ³/ΠΌΠ». Π‘Ρ‹Π»ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ сравнСния Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… частСй бСтСля, ΠΈ Π»ΠΈΡΡ‚ΡŒΡ бСтСля ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π½Π°ΠΈΠ»ΡƒΡ‡ΡˆΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ ингибирования ксантиноксидазы ΠΈ антиоксидантной активности.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π‘Π΅Ρ‚Π΅Π»ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Π» Π»ΡƒΡ‡ΡˆΠΈΠΉ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» ингибирования ксантиноксидазы срСди дСсяти лСкарствСнных растСний. Экстракт Π»ΠΈΡΡ‚ΡŒΠ΅Π² бСтСля ΠΏΠΎΠΊΠ°Π·Π°Π» сильноС ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ксантиноксидазы ΠΈ Π°Π½Ρ‚ΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ‚Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с Ρ†Π΅Π»Ρ‹ΠΌ растСниСм ΠΈ экстрактом стСбля, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΡŽΡ‚ΡΡ ΠΏΡ€ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ ΠΏΠΎΠ΄Π°Π³Ρ€Ρ‹

    Teknik Proteksi Silang Untuk Pengendalian CMV Pada Krisan

    Full text link
    . Rahardjo, I.B., E. Diningsih, and Y. Sulyo. 2008. Cross Protection Technique for Controlling CMV on Chrysanthemum. One of viru s attack chry santhemum is CMV. The alternative to control CMV is the use of vacc ine CARNA 5. The objective of the experiment was to test the cr oss protection tech nique for controlling of CMV on several chry santhemum varieties. The experiment was conduc ted in Virology Laboratory of Indonesian Ornamental Plant Research Institute (IOPRI) in Segu nung, Pacet, Cianjur , West Java, from Augu st to December 2004, using a RC BD split-plot design with 3 replications. The main plot was 5 chry santhemum varieties of White Reagent, Town Talk, Dark Fiji, Stroika, and Revert. The subplot was treatments of vacc ine and CMV, i.e. without vacc ine and CMV, CMV only, vacc ine only, and both vacc ine and CMV. The results of the experiment showed that CARNA 5 vacc ine was able to protect chry santhemum varieties of White Reagent, Town Talk, Dark Fiji, Stroika, and Revert from CMV with normal plant growth and produced good flower quality

    ΠžΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΡ ΠΎΠ±Ρ‰Π΅Π³ΠΎ содСрТания Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² Π² спиртовом экстрактС Persicaria pulchra (Bl.) SojΓ‘k для ингибирования Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π° Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Ρ‹

    Get PDF
    Objectives.Β There has been a rapid increase in the number of diabetic patients since the past few decades in developed and developing countries. This rapid increase is accompanied by alarming costs of treatment. Ξ±-Glucosidase inhibitors are one of the most effective drugs employed for the reduction of postprandial hyperglycemia to manage Type 2 diabetes mellitus. Additionally, flavonoids, a group of natural substances, which are widely distributed in plants and possess variable phenolic structures, exhibit outstanding hypoglycemic activity and are considered as potential Ξ±-glucosidase inhibitors. In Vietnam, Persicaria pulchra (Bl.) SojΓ‘k (P. pulchra) is employed in traditional medications. It possesses high flavonoid contents and its anti-diabetes ability has been hypothesized, although it has attracted less attention for investigation. Hence, the aim of this study is to optimize the condition of the P. pulchra extract to obtain the highest total flavonoid content and measure the bioactivities of P. pulchra, such as the anti-Ξ±-glucosidase and antioxidant activities.Methods.Β The effects of the extracting conditions, including the temperature, extraction time, liquid-to-solid ratio (LSR), and ethanol (C2H5OH) concentration, on the total flavonoid content are investigated via experiments and analyzed by the response surface methodology (RSM). Concurrently, the optimal extraction also determines the anti-Ξ±-glucosidase and antioxidant activities.Results.Β The optimal extraction condition for the highest flavonoid content (530 mg quercetin/g) is determined in 60 min, at 53Β°C, with LSR of 9.46 g/g and C2H5OH concentration of 62%. Moreover, the optimal plant extract exhibits good Ξ±-glucosidase inhibition with a half-maximal inhibitory concentration (IC50) of 22.67 mg/mL, compared to the positive control (acarbose βˆ’7.77 g/mL). Additionally, P. pulchra is proposed to be a potential antioxidant with an IC50 of ~12.68 Β΅g/mL.Conclusions.Β The study confirmed the optimal extraction condition of P. pulchra that will obtain the highest total flavonoid content and revealed the potentials of P. pulchra in Ξ±-glucosidase inhibition and antioxidation.Π¦Π΅Π»ΠΈ. Π’ послСдниС дСсятилСтия Π² Ρ€Π°Π·Π²ΠΈΡ‚Ρ‹Ρ… ΠΈ Ρ€Π°Π·Π²ΠΈΠ²Π°ΡŽΡ‰ΠΈΡ…ΡΡ странах Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ быстрый рост числа Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π΄ΠΈΠ°Π±Π΅Ρ‚ΠΎΠΌ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ сопровоТдаСтся ростом стоимости лСчСния. Π˜Π½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Ρ‹ Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Ρ‹ ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ эффСктивных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ², примСняСмых для сниТСния ΠΏΠΎΡΡ‚ΠΏΡ€Π°Π½Π΄ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅Ρ€Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ ΠΏΡ€ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ сахарного Π΄ΠΈΠ°Π±Π΅Ρ‚Π° 2 Ρ‚ΠΈΠΏΠ°. ΠšΡ€ΠΎΠΌΠ΅ Ρ‚ΠΎΠ³ΠΎ, Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄Ρ‹, Π³Ρ€ΡƒΠΏΠΏΠ° ΠΏΡ€ΠΈΡ€ΠΎΠ΄Π½Ρ‹Ρ… вСщСств, ΡˆΠΈΡ€ΠΎΠΊΠΎ распространСнных Π² растСниях ΠΈ содСрТащих Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Π΅ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Π΅ Ρ„Π΅Π½ΠΎΠ»Π°, ΠΏΡ€ΠΎΡΠ²Π»ΡΡŽΡ‚ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΡƒΡŽ Π³ΠΈΠΏΠΎΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ ΠΌΠΎΠ³ΡƒΡ‚ ΡΠ»ΡƒΠΆΠΈΡ‚ΡŒ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Π°ΠΌΠΈ Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Ρ‹. Π’ΠΎ Π’ΡŒΠ΅Ρ‚Π½Π°ΠΌΠ΅ Persicaria pulchra (Bl.) SojΓ‘k (P. pulchra) ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅Ρ‚ΡΡ Π² Π½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅. Он ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ высоким содСрТаниСм Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² ΠΈ, ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ, противодиабСтичСскими свойствами, хотя исслСдован ΠΌΠ°Π»ΠΎ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, Ρ†Π΅Π»ΡŒΡŽ настоящСго исслСдования являСтся оптимизация экстрагирования P. pulchra для получСния Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ высокого ΠΎΠ±Ρ‰Π΅Π³ΠΎ содСрТания Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ², Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π΅Π³ΠΎ биологичСской активности – Π°Π½Ρ‚ΠΈ-Ξ±-глюкозидазной ΠΈ антиоксидантной. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎ исслСдовано влияниС условий экстрагирования, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹, Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ экстракции, ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡ‚ΡŒ : Ρ‚Π²Π΅Ρ€Π΄ΠΎΠ΅ вСщСство ΠΈ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ этанола, Π½Π° ΠΎΠ±Ρ‰Π΅Π΅ содСрТаниС Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π°Π½Π°Π»ΠΈΠ·Π° повСрхности ΠΎΡ‚ΠΊΠ»ΠΈΠΊΠ°. Показано, Ρ‡Ρ‚ΠΎ ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ условия экстракции ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‚ Π°Π½Ρ‚ΠΈ-Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Π½ΡƒΡŽ ΠΈ Π°Π½Ρ‚ΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ‚Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. НайдСны ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ условия экстракции для получСния максимального содСрТания Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² (530 ΠΌΠ³ ΠΊΠ²Π΅Ρ€Ρ†Π΅Ρ‚ΠΈΠ½Π°/Π³): врСмя экстракции 60 ΠΌΠΈΠ½, Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π° 53 Β°Π‘, ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΆΠΈΠ΄ΠΊΠΎΡΡ‚ΡŒ : Ρ‚Π²Π΅Ρ€Π΄ΠΎΠ΅ вСщСство 9.46 Π³/Π³ ΠΈ концСнтрация этанола 62%. Π Π°ΡΡ‚ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ экстракт, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹ΠΉ Π² ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… условиях, проявляСт Ρ…ΠΎΡ€ΠΎΡˆΠ΅Π΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Ρ‹ с ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠ΅ΠΉ ΠΏΠΎΠ»ΡƒΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ингибирования (IC50) 22.67 ΠΌΠ³/ΠΌΠ» ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌ ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»Π΅ΠΌ (Π°ΠΊΠ°Ρ€Π±ΠΎΠ·Π° – 7.77 Π³/ΠΌΠ»). Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ИсслСдованиС выявило ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ условия экстракции P. pulchra, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΠ΅ ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ высокоС ΠΎΠ±Ρ‰Π΅Π΅ содСрТаниС Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ², ΠΈ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€Π΄ΠΈΠ»ΠΎ пСрспСктивы примСнСния P. pulchra для ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ Ξ±-Π³Π»ΡŽΠΊΠΎΠ·ΠΈΠ΄Π°Π·Ρ‹ ΠΈ антиоксидантного окислСния
    • …
    corecore