Reading Scripture through a mystical lens

In addition to the unprecedented interest in spirituality in recent decades, both at a popular level and also as an academic discipline, there has also been a resurgence of research dealing with spirituality and scripture. It is readily acknowledged that the hegemony of the historical-critical method is no longer tenable. As a method which sees the text as an artifact of history, there is minimal, if any, attempt to understand the experience of those who produced the text; it concentrates on a literal interpretation, at the expense of the polysemous nature of scripture. Contemporary scriptural studies, however, have witnessed a sea-change in interpretive methods of such magnitude, that it is difficult to keep up with current scholarship in this field. Within this paradigm shift, the importance of a spiritual reading of scripture has now come to the fore. More specifically, reading scripture through a mystical lens, as originally seen, inter alia, in the works of Origen, has taken its place, if not centre stage, at least on the stage, and no longer in the wings. Utilising the insights of a French Carmelite, Elisabeth Catez, a mystical reading of Paul exemplifies this new, yet ancient, hermeneutical method

The “turn” to spirituality

The term “spirituality” is difficult to define, given the equivocal meanings attributed to it, and the tendency to equate this phenomenon with “piety” or “otherworldliness”. Such an approach is far too narrow, and does not take into account that “spirituality” needs to be seen in a much wider context. Spirituality refers to the raison-d’être of one’s existence, the meaning and values to which one ascribes. Thus everyone embodies a spirituality, be it nihilistic, materialistic, humanistic, or religious. There are diverse spiritualities, each one culture-specific, expressing its own historical, sociological, theological, linguistic and philosophical orientation. Post-patriarchal and telluric, contemporary spirituality affects all areas of society, including the business world, education, health care, the arts, ecology, politics, religion and particularly the academy, where new programmes in spirituality are attracting a large number of students. The new surge of interest in spirituality is a force for personal and societal transformation

Discerning the mystical wisdom of the Bhagavad Gita and John of the Cross

The 21st century is characterised by a global spirituality. Presently, and more than ever, access to the great religious traditions has enabled many to tap into the wisdom of other cultures. While the respective epistemological foundations of diverse traditions may differ, mutual understanding and respectful dialogue nevertheless facilitate respect for the other and offer opportunities for mutual enrichment. This leads to the recognition that there are multiple dimensions and expressions of the sacred. From within this interspiritual approach, an analysis of the mystical wisdom of the Bhagavad Gita and John of the Cross clearly points to the central theme of discerning the real from the unreal. This leads to detachment from/lack of desire for and, finally, surrender to the Divine

Contemporary Christian Spirituality: An “Encompassing Field”

Contemporary Christian spirituality, understood as both an experiential, lived-life phenomenon and an academic discipline gives a new-found universal perspective to the reflective Christian. It constitutes an encompassing, incorporative “field” through occupying a “give-and-take” inter-disciplinary place in a general academy of Spirituality and through repossession of its own traditions, insights and ecumenical spiritual landscape. These discoveries are further enhanced through contemporary Christian spirituality’s own critical appreciation of globalisation and postmodernism. Contemporary Christian spirituality, at its best, constitutes a world-appreciative openness that nevertheless sustains its own unique identity. In short, contemporary Christian spirituality offers a livedfaith and academic discipline that is globally conscious and universally aligned. It operates out of a credible contextual  rationale for our times

Contemporary Christian spirituality: a worldly embodiment

Contemporary renascent spirituality secures for itself a motif of materiality and physical embodiment. This embodiment pertains to renascent spirituality both as lived-life experience and particularly as contemporary academic discipline. The influential sources of an embodied spirituality are to be found in spirituality’s reflective self-understanding, the rich resources of the Christian tradition, the growing interest in lived Christian experience as such, and the post-Vatican II conciliatory spirit and momentum. Renascent spirituality not only accommodates and endorses embodiment and “worldly” materiality; it also realises a new wholeness and integration for Christian spirituality. While it might seem a commonplace to defend Christian spirituality’s embodied, incarnational reality, it is clear that spirituality has not always been so understood, even constituting a pejorative connotation at times as something essentially detached, disembodied and inferentially dualistic. Spirituality in its revived sense holds within itself and its inherited tradition the potential to critique such disembodiment while simultaneously securing the mystery and transcendent dimension of embodied Christian living

Knowledge, Practice, and Attitudes of Physicians in Low- and Middle-Income Countries on Fertility and Pregnancy-Related Issues in Young Women With Breast Cancer

PURPOSE: Fertility and pregnancy-related issues are highly relevant for young ( 64 40 years) patients with breast cancer. Limited evidence exists on knowledge, practice, and attitudes of physicians from low- and middle-income countries (LMICs) regarding these issues. METHODS: A 19-item questionnaire adapted from an international survey exploring issues about fertility preservation and pregnancy after breast cancer was sent by e-mail between November 2019 and January 2020 to physicians from LMICs involved in breast cancer care. Descriptive analyses were performed. RESULTS: A total of 288 physicians from Asia, Africa, America, and Europe completed the survey. Median age was 38 years. Responders were mainly medical oncologists (44.4%) working in an academic setting (46.9%). Among responders, 40.2% and 53.8% reported having never consulted the available international guidelines on fertility preservation and pregnancy after breast cancer, respectively. 25.0%, 19.1%, and 24.3% of responders answered to be not at all knowledgeable about embryo, oocyte, or ovarian tissue cryopreservation, respectively; 29.2%, 23.6%, and 31.3% declared that embryo, oocyte, and ovarian tissue cryopreservation were not available in their countries, respectively. 57.6% of responders disagreed or were neutral on the statement that controlled ovarian stimulation can be considered safe in patients with breast cancer. 49.7% and 58.6% of responders agreed or were neutral on the statement that pregnancy in breast cancer survivors may increase the risk of recurrence overall or only in those with hormone receptor-positive disease, respectively. CONCLUSION: This survey showed suboptimal knowledge, practice, and attitudes of physicians from LMICs on fertility preservation and pregnancy after treatment completion in young women with breast cancer. Increasing awareness and education on these aspects are needed to improve adherence to available guidelines and to promote patients' oncofertility counseling

Knowledge, Practice, and Attitudes of Physicians in Low- and Middle-Income Countries on Fertility and Pregnancy-Related Issues in Young Women With Breast Cancer

PURPOSE Fertility and pregnancy-related issues are highly relevant for young (≤ 40 years) patients with breast cancer. Limited evidence exists on knowledge, practice, and attitudes of physicians from low- and middle-income countries (LMICs) regarding these issues. METHODS A 19-item questionnaire adapted from an international survey exploring issues about fertility preservation and pregnancy after breast cancer was sent by e-mail between November 2019 and January 2020 to physicians from LMICs involved in breast cancer care. Descriptive analyses were performed. RESULTS A total of 288 physicians from Asia, Africa, America, and Europe completed the survey. Median age was 38 years. Responders were mainly medical oncologists (44.4%) working in an academic setting (46.9%). Among responders, 40.2% and 53.8% reported having never consulted the available international guidelines on fertility preservation and pregnancy after breast cancer, respectively. 25.0%, 19.1%, and 24.3% of responders answered to be not at all knowledgeable about embryo, oocyte, or ovarian tissue cryopreservation, respectively; 29.2%, 23.6%, and 31.3% declared that embryo, oocyte, and ovarian tissue cryopreservation were not available in their countries, respectively. 57.6% of responders disagreed or were neutral on the statement that controlled ovarian stimulation can be considered safe in patients with breast cancer. 49.7% and 58.6% of responders agreed or were neutral on the statement that pregnancy in breast cancer survivors may increase the risk of recurrence overall or only in those with hormone receptor–positive disease, respectively. CONCLUSION This survey showed suboptimal knowledge, practice, and attitudes of physicians from LMICs on fertility preservation and pregnancy after treatment completion in young women with breast cancer. Increasing awareness and education on these aspects are needed to improve adherence to available guidelines and to promote patients' oncofertility counseling.Supported in part by the Italian Ministry of Health—5x1000 funds 2017 (no grant number) and the Italian Association for Cancer Research (AIRC; MFAG 2020 ID 24698)

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

Alzheimer’s disease (AD) is the most common type of senile dementia in aging populations. Amyloid β (Aβ)-mediated dysregulation of ionic homeostasis is the prevailing underlying mechanism leading to synaptic degeneration and neuronal death. Aβ-dependent ionic dysregulation most likely occurs either directly via unregulated ionic transport through the membrane or indirectly via Aβ binding to cell membrane receptors and subsequent opening of existing ion channels or transporters. Receptor binding is expected to involve a high degree of stereospecificity. Here, we investigated whether an Aβ peptide enantiomer, whose entire sequence consists of d-amino acids, can form ion-conducting channels; these channels can directly mediate Aβ effects even in the absence of receptor–peptide interactions. Using complementary approaches of planar lipid bilayer (PLB) electrophysiological recordings and molecular dynamics (MD) simulations, we show that the d-Aβ isomer exhibits ion conductance behavior in the bilayer indistinguishable from that described earlier for the l-Aβ isomer. The d isomer forms channel-like pores with heterogeneous ionic conductance similar to the l-Aβ isomer channels, and the d-isomer channel conductance is blocked by Zn2+, a known blocker of l-Aβ isomer channels. MD simulations further verify formation of β-barrel-like Aβ channels with d- and l-isomers, illustrating that both d- and l-Aβ barrels can conduct cations. The calculated values of the single-channel conductance are approximately in the range of the experimental values. These findings are in agreement with amyloids forming Ca2+ leaking, unregulated channels in AD, and suggest that Aβ toxicity is mediated through a receptor-independent, nonstereoselective mechanism

Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection

<p>Abstract</p> <p>Background</p> <p>The incidence of gastric cardiac adenocarcinoma (GCA) has been increasing in the past two decades in China, but the molecular changes relating to carcinogenesis have not been well characterised.</p> <p>Methods</p> <p>In this study, we used a comparative proteomic approach to analyse the malignant and nonmalignant gastric cardia epithelial cells isolated by navigated laser capture microdissection (LCM) from paired surgical specimens of human GCA.</p> <p>Results</p> <p>Twenty-seven spots corresponding to 23 proteins were consistently differentially regulated. Fifteen proteins were shown to be up-regulated, while eight proteins were shown to be down-regulated in malignant cells compared with nonmalignant columnar epithelial cells. The identified proteins appeared to be involved in metabolism, chaperone, antioxidation, signal transduction, apoptosis, cell proliferation, and differentiation. In addition, expressions of HSP27, 60, and Prx-2 in GCA specimens were further confirmed by immunohistochemical and western blot analyses.</p> <p>Conclusion</p> <p>These data indicate that the combination of navigated LCM with 2-DE provides an effective strategy for discovering proteins that are differentially expressed in GCA. Such proteins may contribute in elucidating the molecular mechanisms of GCA carcinogenesis. Furthermore, the combination provides potential clinical biomarkers that aid in early detection and provide potential therapeutic targets.</p