Pilot actions in European cities - Stuttgart

The field of urban climatology has a long tradition in Stuttgart. It exists as discipline in Stuttgart since 1938. Stuttgart was the first city to establish its own Department of Climatology to research ways of improving the flow of fresh air into the city and to reduce thermal stress in most populated city districts. The specialist department of Urban Climatology, within the Environmental Protection Office, deals with tasks relating to environmental meteorology within the scope of air pollution control and also relating to urban and global climate protection. So in Stuttgart the urban heat island phenomenon (UHI) is studied for several decades, leading to a high level understanding of the UHI and the problems which it causes. The UHI causes an increase in air temperatures and thermal stress, that are identified as most negative impacts on human health and urban living. In the view of global climate change and the predicted temperature rise for the Stuttgart region of 1.5–2 K in this century, the negative impacts of UHI on human health and urban living will become more problematic in the future. According to the results of climate models the frequency of very hot days is expected to jump by nearly 30 % at the end of the century. The rising temperatures due to the global climate change in combination with the temperature shift as a result of the UHI will intensify the heat stress in urban areas, that leads to a significant increasing risk to human health, in particular to the very young and elderly. Not least due its importance for the human health and the quality of urban life in Stuttgart, the UHI is focussed by urban planners and is noticed by the future development of the city. Within the pilot action study in Stuttgart several measure for reducing the UHI and the impacts on urban living and human health are analysed by the use of micro-scale and macro-scale simulations. With the help of these analysis realisable measure are selected. The most useful measures are implemented into a developmoutline plan for the redevelopment of the city district Stuttgart-West by the municipal urban planners

Field-induced charge transport at the surface of pentacene single crystals: a method to study charge dynamics of 2D electron systems in organic crystals

A method has been developed to inject mobile charges at the surface of organic molecular crystals, and the DC transport of field-induced holes has been measured at the surface of pentacene single crystals. To minimize damage to the soft and fragile surface, the crystals are attached to a pre-fabricated substrate which incorporates a gate dielectric (SiO_2) and four probe pads. The surface mobility of the pentacene crystals ranges from 0.1 to 0.5 cm^2/Vs and is nearly temperature-independent above ~150 K, while it becomes thermally activated at lower temperatures when the induced charges become localized. Ruling out the influence of electric contacts and crystal grain boundaries, the results contribute to the microscopic understanding of trapping and detrapping mechanisms in organic molecular crystals.Comment: 14 pages, 4 figures. Submitted to J. Appl. Phy

Psychological Factors Relevant to the Prehospital and In-hospital Phases of Acute Myocardial Infarction

Recognition and treatment of psychological factors relevant to the acute prehospital and in-hospital phases of myocardial infarction (Ml) are reviewed. Various emotions and personality characteristics can be both risk factors for and consequences of acute Ml. Components of the Type A behavior pattern and levels of somatic and emotional awareness have been linked with excessive treatment-seeking delay for Ml patients. Psychiatric conditions such as panic disorder may mimic symptomatic presentation of Ml and therefore have implications for differential diagnosis in the emergency room. Additionally. anxiety, depression, and neurobehavioral disorders such as delirium are relatively common during the hospitalization period and may contribute to potentially lethal complications of Ml. Because psychological factors are associated with prognosis during each phase of Ml, the identification and treatment of such factors are crucial in providing comprehensive care for MI patients

239 + 240Pu from “contaminant” to soil erosion tracer: Where do we stand?

As soil erosion is the major threat to one of the most essential resources of humankind, methods to quantify soil redistribution are crucial for agro-environmental assessment as well as for optimisation of soil conservation practices. The use of fallout radionuclides (FRN) as soil redistribution tracers is, next to modelling, currently the most promising approach for assessing soil erosion. This review aims to evaluate the suitability of Plutonium (Pu) in general and the 239+240Pu isotopes in particular as soil redistribution tracers. It provides information on its origin, distribution and behaviour in soils and in the environment. Analytical methods, their recent advances as well as limitations, are discussed. To establish the current state of knowledge and to deepen our understanding, particular attention is given to the main existing achievements and findings based on using 239+240Pu as soil erosion tracer in agroecosystems. We further discuss similarities and differences to other more mature FRN techniques such as the 137Cs based approach which has been until now the most widely used method. We conclude that 239+240Pu has the potential to become the next generation of soil redistribution tracer compared to the more mature FRN techniques mostly due to (i) its long half-life guaranteeing its long-term availability in the environment, (ii) its analytical advantage in terms of measurement precision and measurement time and (iii) its greater homogeneity at reference sites due to its main origin from past atmospheric nuclear weapon tests. In identifying some key future research opportunities and needs, we hope to refine the efficiency of this promising agro-environmental tracer for effective soil redistribution studies under future climate and land use change

Preliminary u isotopic data in the Cádiz coastal area (SW Spain) as proxy for coastal groundwater discharge

Peer Reviewe

Nosocomial nontyphoidal salmonellosis after antineoplastic chemotherapy: reactivation of asymptomatic colonization?

An increased frequency of nontyphoidal salmonellosis is well established in cancer patients, but it is unclear whether this represents increased susceptibility to exogenous infection or opportunistic, endogenous reactivation of asymptomatic carriage. In a retrospective study, a simple case definition was used to identify the probable presence of reactivation salmonellosis in five cancer patients between 1996 and 2002. Reactivation salmonellosis was defined as the development of nosocomial diarrhea >72h after admission and following the administration of antineoplastic chemotherapy in an HIV-seronegative cancer patient who was asymptomatic on admission, in the absence of epidemiological evidence of a nosocomial outbreak. Primary salmonellosis associated with unrecognized nosocomial transmission or community acquisition and an unusually prolonged incubation period could not entirely be ruled out. During the same time period, another opportunistic infection, Pneumocystis pneumonia, was diagnosed in six cancer patients. Presumably, asymptomatic intestinal Salmonella colonization was converted to invasive infection by chemotherapy-associated intestinal mucosal damage and altered innate immune mechanisms. According to published guidelines, stool specimens from patients hospitalized for longer than 72h should be rejected unless the patient is neutropenic or ≧65 years old with significant comorbidity. However, in this study neutropenia was present in only one patient, and four patients were <65 years old. Guidelines should thus be revised in order not to reject stool culture specimens from such patients. In cancer patients, nosocomial salmonellosis can occur as a chemotherapy-triggered opportunistic reactivation infection that may be similar in frequency to Pneumocystis pneumoni

Understanding Chest Pain: What Every Psychologist Should Know

Chest pain is one of the most frequent presenting complaints in Emergency Rooms and other medical settings. A considerable number of these patients do not have significant coronary artery disease. This led to plausible alternative explanations for these presenting symptoms and these patients tend to have unremarkable cardiac outcomes. Nevertheless, many studies have also documented that symptoms and related disability persist in the face of reassurances about benign cardiac status. Given the implied threat of chest pain (e.g., myocardial infarction) and the presence of chest pain symptoms in other noncardiac conditions (including anxiety and panic), it is not surprising that many of these patients present with considerable emotional distress. Consequently, chest pain symptoms represent diagnostic and treatment dilemmas for physicians and psychologists alike. The extent to which cardiac and noncardiac factors contribute to all forms of chest pain remains unknown. The function of this review is to provide mental health professionals with a primer on relevant clinical issues in chronic chest pain. We examine several common medical and psychiatric causes of chronic chest pain and selectively review (1) the relevant medical and psychiatric diagnostic and treatment considerations for chest pain and (2) the hypothetical biobehavioral mechanisms relevant to psychological intervention, (3) while expanding on existing conceptual models for understanding chest pain, and (4) offering some suggestions for future research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44862/1/10880_2004_Article_418731.pd

Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland

The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of life. This development prompted a Swiss expert panel to re-evaluate the current status and formulate updated clinical recommendations for the diagnosis and treatment of plasma cell myeloma. These recommendations should help clinicians in their decision making to achieve the best outcome based on currently available data

Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B)

Background The superiority of a chemotherapy with doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP) in comparison with cyclophosphamide, doxorubicin, vincristin and prednisone plus radiotherapy for young patients with localized diffuse large B-cell lymphoma (DLBCL) was previously demonstrated. We report the results of a trial which evaluates the role of rituximab combined with ACVBP (R-ACVBP) in these patients. Patients and methods Untreated patients younger than 66 years with stage I or II DLBCL and no adverse prognostic factors of the age-adjusted International Prognostic Index were randomly assigned to receive three cycles of ACVBP plus sequential consolidation with or without the addition of four infusions of rituximab. Results A total of 223 patients were randomly allocated to the study, 110 in the R-ACVBP group and 113 in the ACVBP group. After a median follow-up of 43 months, our 3-year estimate of event-free survival was 93% in the R-ACVBP group and 82% in the ACVBP group (P = 0.0487). Three-year estimate of progression-free survival was increased in the R-ACVBP group (95% versus 83%, P = 0.0205). Overall survival did not differ between the two groups with a 3-year estimates of 98% and 97%, respectively (P = 0.686). Conclusion In young patients with low-risk localized DLBCL, rituximab combined with three cycles of ACVBP plus consolidation is significantly superior to ACVBP plus consolidation alon