3,765 research outputs found
Power systems research at MSFC
Power systems research reviews at Marshall Space Flight Cente
Unexpected Magnetism of Small Silver Clusters
The ground-state electronic, structural, and magnetic properties of small
silver clusters, Ag (2n22), have been studied using a linear
combination of atomic Gaussian-type orbitals within the density functional
theory. The results show that the silver atoms, which are diamagnetic in bulk
environment, can be magnetic when they are grouped together in clusters. The
Ag cluster with icosahedral symmetry has the highest magnetic moment per
atom among the studied silver clusters. The cluster symmetry and the reduced
coordination number specific of small clusters reveal as a fundamental factor
for the onset of the magnetism.Comment: 4 pages, 4 figure
Understanding wind turbine power converter reliability under realistic wind conditions
The reliability of wind turbine power converters is crucial for analyzing wind energy project costs, and for estimating maintenance and downtime. The published literature in this field relies on evaluating the reliability effect of wind speed to estimate the converter lifetime. However, this paper demonstrates that wind turbulence intensity, which has not been widely considered in similar reliability analyses, shows a significant impact on converter lifetime. This paper uses 821 10‐min wind speed time series sampled at 1 Hz on the two most commonly deployed wind turbine converter topologies: the two‐level voltage source and the three‐level neutral point clamped. Electromechanical and thermal modelling, combined with statistical analysis shows that mean wind speed and turbulence intensity both impact the lifetime of both converter topologies. However, the paper estimates that the three‐level converter can operate 2.4 to 4.0 times longer than the two‐level converter depending on the operating wind speed and turbulence intensity
Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease
Background
Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study.
Methodology and Principal Findings
A total of 120 patients were recruited (54% male, mean age 55±14 years, mean glomerular filtration rate 50±13 ml/min/1.73 m2). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60±1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56±16 vs. 48±12 g/m2, P = 0.002), as did patients with femoral Z-scores below zero (56±15 vs. 49±13 g/m2, P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Z-score inversely correlated with left ventricular mass (r = −0.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001).
Conclusions
In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted
Problematising international placements as a site of intercultural learning
This paper theorises some of the learning outcomes of a three-year project concerning student learning in international social work placements in Malaysia. The problematic issue of promoting cultural and intercultural competence through such placements is examined, where overlapping hegemonies are discussed in terms of isomorphism of social work models, that of the nation state, together with those relating to professional values and knowledge, and the tyrannies of received ideas. A critical discussion of cultural competence as the rationale for international placements is discussed in terms of the development of the graduating social worker as a self-reflexive practitioner. The development of sustainable international partnerships able to support student placement and the issue of non-symmetrical reciprocation, typical of wide socio-economic differentials across global regions, is additionally discussed
Enabling the new economic actor: data protection, the digital economy, and the Databox
This paper offers a sociological perspective on data protection regulation and its relevance to design. From this perspective, proposed regulation in Europe and the USA seeks to create a new economic actor—the consumer as personal data trader—through new legal frameworks that shift the locus of agency and control in data processing towards the individual consumer or “data subject”. The sociological perspective on proposed data regulation recognises the reflexive relationship between law and the social order, and the commensurate needs to balance the demand for compliance with the design of computational tools that enable this new economic actor. We present the Databox model as a means of providing data protection and allowing the individual to exploit personal data to become an active player in the emerging data economy.The authors acknowledge the support of the EPSRC, Grants EP/M001636/1, EP/M02315X/1, EP/N028260/1, and EU FP7 Grant 611001.This is the final version of the article. It first appeared from [PUBLISHER] via http://dx.doi.org/10.1007/s00779-016-0939-
Deformation and Depinning of Superconducting Vortices from Artificial Defects: A Ginzburg-Landau Study
Using Ginzburg-Landau theory, we have performed detailed studies of vortices
in the presence of artificial defect arrays, for a thin film geometry. We show
that when a vortex approaches the vicinity of a defect, an abrupt transition
occurs in which the vortex core develops a ``string'' extending to the defect
boundary, while simultaneously the supercurrents and associated magnetic flux
spread out and engulf the defect. Current induced depinning of vortices is
shown to be dominated by the core string distortion in typical experimental
situations. Experimental consequences of this unusual depinning behavior are
discussed.Comment: 10 pages,9 figure
Challenges facing community health workers in Brazil’s Family Health Strategy: A qualitative study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144641/1/hpm2456.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144641/2/hpm2456_am.pd
Scanning Tunneling Spectroscopy in MgB2
We present scanning tunneling microscopy measurements of the surface of
superconducting MgB2 with a critical temperature of 39K. In zero magnetic field
the conductance spectra can be analyzed in terms of the standard BCS theory
with a smearing parameter Gamma. The value of the superconducting gap is 5.2
meV at 4.2 K, with no experimentally significant variation across the surface
of the sample. The temperature dependence of the gap follows the BCS form,
fully consistent with phonon-mediated superconductivity in this novel
superconductor. The application of a magnetic field induces strong
pair-breaking as seen in the conductance spectra in fields up to 6 T.Comment: 4 pages, 4 figure
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating cognitive dysfunction in both rodents and humans. Among these is GSK1034702, described previously as a potent M1 receptor allosteric agonist, which showed pro-cognitive effects in rodents and improved immediate memory in a clinical nicotine withdrawal test but induced significant side-effects. Here we provide evidence using ligand binding, chemical biology and functional assays to establish that rather than the allosteric mechanism claimed, GSK1034702 interacts in a bitopic manner at the M1 mAChR such that it can concomitantly span both the orthosteric and an allosteric binding site. The bitopic nature of GSK1034702 together with the intrinsic agonist activity and a lack of muscarinic receptor subtype selectivity reported here, all likely contribute to the adverse effects of this molecule in clinical trials. We conclude that these properties, whilst imparting beneficial effects on learning and memory, are undesirable in a clinical candidate due to the likelihood of adverse side effects. Rather, our data supports the notion that "pure" positive allosteric modulators showing selectivity for the M1 mAChR with low levels of intrinsic activity would be preferable to provide clinical efficacy with low adverse responses
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