Surface treatments for nickel and nickel-base alloys

Surface treatments of nickel and nickel alloys by diffusion coating, electroplating, explosive hardening, peening, and other method

Use of cumulative mortality data in patients with acute myocardial infarction for early detection of variation in clinical practice: observational study

OBJECTIVES: Use of cumulative mortality adjusted for case mix in patients with acute myocardial infarction for early detection of variation in clinical practice. DESIGN: Observational study. SETTING: 20 hospitals across the former Yorkshire region. PARTICIPANTS: All 2153 consecutive patients with confirmed acute myocardial infarction identified during three months. MAIN OUTCOME MEASURES: Variable life­adjusted displays showing cumulative differences between observed and expected mortality of patients; expected mortality calculated from risk model based on admission characteristics of age, heart rate, and systolic blood pressure. RESULTS: The performance of two individual hospitals over three months was examined as an example. One, the smallest district hospital in the region, had a series of 30 consecutive patients but had five more deaths than predicted. The variable life­adjusted display showed minimal variation from that predicted for the first 15 patients followed by a run of unexpectedly high mortality. The second example was the main tertiary referral centre for the region, which admitted 188 consecutive patients. The display showed a period of apparently poor performance followed by substantial improvement, where the plot rose steadily from a cumulative net lives saved of - 4 to 7. These variations in patient outcome are unlikely to have been revealed during conventional audit practice. CONCLUSIONS: Variable life­adjusted display has been integrated into surgical care as a graphical display of risk­adjusted survival for individual surgeons or centres. In combination with a simple risk model, it may have a role in monitoring performance and outcome in patients with acute myocardial infarction

Monolayer-Protected Nanoparticle Doped Xerogels as Functional Components of Amperometric Glucose Biosensors

First-generation amperometric glucose biosensors incorporating alkanethiolate-protected gold nanoparticles, monolayer protected clusters (MPCs), within a xerogel matrix are investigated as model systems for nanomaterial-assisted electrochemical sensing strategies. The xerogel biosensors are comprised of platinum electrodes modified with composite films of (3-mercaptopropyl)trimethoxy silane xerogel embedded with glucose oxidase enzyme, doped with Au225(C6)75 MPCs, and coated with an outer polyurethane layer. Electrochemistry and scanning/transmission electron microscopy, including cross-sectional TEM, show sensor construction, humidity effects on xerogel structure, and successful incorporation of MPCs. Analytical performance of the biosensor scheme with and without MPC doping of the xerogel is determined from direct glucose injection during amperometry. MPC-doped xerogels yield significant enhancement of several sensor attributes compared to analogous films without nanoparticles: doubling of the linear range, sensitivity enhancement by an order of magnitude, and 4-fold faster response times accompany long-term stability and resistance to common interfering agents that are competitive with current glucose biosensing literature. Ligand chain length and the MPC/silane ratio studies suggest the MPC-induced enhancements are critically related to structure–function relationships, particularly those affecting interparticle electronic communication where the MPC network behaves as a three-dimensional extension of the working electrode into the xerogel film, reducing the system’s dependence on diffusion and maximizing efficiency of the sensing mechanism. The integration of MPCs as a functional component of amperometric biosensor schemes has implications for future development of biosensors targeting clinically relevant species

Functional Layer-By-Layer Design of Xerogel-Based 1st Generation Amperometric Glucose Biosensors

Xerogel-based first-generation amperometric glucose biosensors, constructed through specific layer-by-layer assembly of films featuring glucose oxidase doped xerogel, a diffusion-limiting xerogel layer, and capped with both electropolymerized polyphenol and blended polyurethane semipermeable membranes, are presented. The specific combination of xerogels formed from specific silane precursors, including propyl-trimethoxysilane, isobutyl-trimethoxysilane, octyl-trimethoxysilane, and hydroxymethyl-triethoxysilane, exhibit impressive dynamic and linear ranges of detection (e.g., ≥24–28 mM glucose) and low response times, as well as significant discrimination against common interferent species such as acetaminophen, ascorbic acid, sodium nitrite, oxalic acid, and uric acid as determined by selectivity coefficients. Additionally, systematic electrochemical and contact angle studies of different xerogel silane precursors, varying in structure, chain length, and/or functional group, reveal that sensor performance is more dependent on the tunable porosity/permeability of the layered interfaces rather than the hydrophobic character or functional groups within the films. While the sensing performance largely exceeds that of existing electrochemical glucose sensing schemes in the literature, the presented layered approach establishes the specific functionality of each layer working in concert with each other and suggests that the strategy may be readily adaptable to other clinically relevant targets and is amenable to miniaturization for eventual in situ or in vivo sensing

A Statistical Method for Estimating Luminosity Functions using Truncated Data

The observational limitations of astronomical surveys lead to significant statistical inference challenges. One such challenge is the estimation of luminosity functions given redshift $z$ and absolute magnitude $M$ measurements from an irregularly truncated sample of objects. This is a bivariate density estimation problem; we develop here a statistically rigorous method which (1) does not assume a strict parametric form for the bivariate density; (2) does not assume independence between redshift and absolute magnitude (and hence allows evolution of the luminosity function with redshift); (3) does not require dividing the data into arbitrary bins; and (4) naturally incorporates a varying selection function. We accomplish this by decomposing the bivariate density into nonparametric and parametric portions. There is a simple way of estimating the integrated mean squared error of the estimator; smoothing parameters are selected to minimize this quantity. Results are presented from the analysis of a sample of quasars.Comment: 30 pages, 9 figures, Accepted for publication in Ap

Relating software requirements and architectures using problem frames

Problem frames provide a means of analyzing and decomposing problems. They emphasise the world outside of the computer, helping the developer to focus on the problem domain, instead of drifting into inventing solutions. However, even modestly complex problems can force us into detailed consideration of the architecture of the solution. This is counter to the intention of the problem frames approach, which is to delay consideration of the solution space until a good understanding of the problem is gained. We therefore extend problem frames, allowing architectural structures, services and artifacts to be considered as part of the problem domain. Through a case study, we show how this extension enhances the applicability of problem frames in permitting an architecture-based approach to software development. We conclude that, through our extension, the applicability of problem frames is extended to include domains with existing architectural support

The Indian family on UK reality television: Convivial culture in salient contexts

This is the author's accepted manuscript. The final published article is available from the link below, copyright 2012 @ the author.This article demonstrates how The Family (2009), a fly-on-the wall UK reality series about a British Indian family, facilitates both current public service broadcasting requirements and mass audience appeal. From a critical cultural studies perspective, the author examines the journalistic and viewer responses to the series where authenticity, universality, and comedy emerge as major themes. Textual analysis of the racialized screen representations also helps locate the series within the contexts of contested multiculturalism, genre developments in reality television and public service broadcasting. Paul Gilroy’s concept of convivial culture is used as a frame in understanding how meanings of the series are produced within a South Asian popular representational space. The author suggests that the social comedy taxonomy is a prerequisite for the making of this particular observational documentary. Further, the popular (comedic) mode of conviviality on which the series depends is both expedient and necessary within the various sociopolitical contexts outlined

Mass and dust in the disk of a spiral lens galaxy

Gravitational lensing is a potentially important probe of spiral galaxy structure, but only a few cases of lensing by spiral galaxies are known. We present Hubble Space Telescope and Magellan observations of the two-image quasar PMN J2004-1349, revealing that the lens galaxy is a spiral galaxy. One of the quasar images passes through a spiral arm of the galaxy and suffers 3 magnitudes of V-band extinction. Using simple lens models, we show that the mass quadrupole is well-aligned with the observed galaxy disk. A more detailed model with components representing the bulge and disk gives a bulge-to-disk mass ratio of 0.16 +/- 0.05. The addition of a spherical dark halo, tailored to produce an overall flat rotation curve, does not change this conclusion.Comment: ApJ, in press [9pp, 7 figs

Collective oscillations of two colliding Bose-Einstein condensates

Two 87Rb condensates (F=2, m_f=2 and m_f=1) are produced in highly displaced harmonic traps and the collective dynamical behaviour is investigated. The mutual interaction between the two condensates is evidenced in the center-of-mass oscillations as a frequency shift of 6.4(3)%. Calculations based on a mean-field theory well describe the observed effects of periodical collisions both on the center-of-mass motion and on the shape oscillations.Comment: 5 pages, 3 figures, revtex - revised versio