NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review

Narrow-band imaging (NBI) represents a valid aid in laryngeal squamous cell carcinoma (LSCC) diagnosis for detecting vascular changes. However, LSCC and laryngeal papillomatosis (LP) show similar vascular patterns that may lead to misdiagnosis and improper treatment. This review aims to deepen this NBI limit in order to stress a careful preoperative evaluation of laryngeal lesions. The research was carried out on PubMed, Web of Science and Scopus databases using specific keywords. The topic of research was assessed by these parameters: accuracy, sensitivity, specificity, and positive and negative predictive values. This review included only five articles: they demonstrated that NBI is better than white-light endoscopy in detecting LSCC and LP. They also reported that LP is frequently mistaken for LSCC, resulting in high rates of false positives using NBI. This is the first review that emphasized this NBI limitation in distinguishing between LP and LSCC in cases of a type V pattern of intraepithelial papillary capillary loop. Although NBI application increased the rate of early cancer detection, LP reduces NBI accuracy. This drawback may lead to misdiagnosis and improper treatment. Our advice is to be careful in cases of type V pattern on NBI and to research LP epithelial and clinical features because it could be a pitfall

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Human papillomavirus is a sexually transmitted virus that is responsible not only for uterine cervical cancer, but also for the oral and oropharyngeal cancers. In this latter case, the virus indiscriminately affects both sexes at any age. Vaccination plays a key role in preventing infection and its possible consequences. Therefore, this study aimed to assess the degree of awareness of papillomavirus infection and its possible prevention in the Sicilian population. A prospective observational study was carried out on the Sicilian population through a self-administered questionnaire, consisting of 10 multiple-choice questions. The survey lasted from June 2021 to December 2021. A total of 844 respondents were included: 60.90% were female and 53.55% were aged between 21 and 30 years. Most of the surveyed population knew about the virus and the existence of the vaccine, however, many of them did not know about virus's effects on the oral and oropharyngeal sites (49.17%), or about the indication for vaccination for males (39.69%). Oral and oropharyngeal papillomavirus-related cancers are an increasingly frequent finding, especially in young adults. Therefore, it is necessary and quite mandatory to educate the population about the risks that certain voluptuous habits may cause, with the help of general practitioners, schools, social media, and social networks

Fatigue behavior and cyclic damage of peek short fiber reinforced composites

Fatigue strength and failure mechanisms of short fiber reinforced (SFR) PEEK have been investigated in the past by several research groups. However some relevant aspects of the fatigue behavior of these materials, like cyclic creep and fatigue damage accumulation and modeling, have not been studied yet, in particular in presence of both fillers and short fibers as reinforcement. In the present research these aspects were considered by carrying out uni-axial fatigue tests in load control (cycle ratio R = 0) on neat PEEK and PEEK based composites reinforced either with short carbon fibers only or with addition of fillers (graphite and PTFE). For each material stress-life curves were obtained and compared. Fatigue fracture surfaces were analyzed to identify failure mechanisms in presence of different reinforcement types. The evolution of cyclic creep strain was also monitored as a function of the number of cycles, thus allowing investigation on the correlation between cyclic creep parameters and fatigue life. The evolution of cyclic damage with loading cycles was then compared by defining a damage parameter related to the specimen stiffness reduction observed during the tests. Progressive cyclic damage evolution of short fiber reinforced PEEK composites presented significantly different patterns depending on applied stress level and on the presence of different reinforcement typologies. In order to reproduce the different fatigue damage kinetics and stages of progressive damage accumulation observed experimentally, a cyclic damage model was finally developed and implemented into a finite element code by which a satisfactory agreement between numerical prediction and experimental data at different stress levels for each examined material

upper limb rehabilitation robotics after stroke a perspective from the university of padua italy

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Physicochemical parameters and antibiotics residuals in Algerian honey

The aim of the present study was to evaluate the quality of 36 samples of different honey type supplied by local producers from Algeria in order to verify its compliance with the standards of Codex Alimentarius and  European Union (EU). For that, five physicochemical parameters were  analyzed using the HPLC method: hydroxyl-methyl furfural (HMF), sugars, diastase activity and search of antibiotic contamination with streptomycin and tetracycline. The physicochemical analyses of the Algerian honeys show that 56% of samples correspond to Codex standards and 44% not in  conformity with the standards required by the Codex Alimentarius and EU, because part of the samples had one or more defects. The percentage not in conformity was due to the high rates of hydroxyl-methyl furfural, sucroseand also to the low enzyme level. Analysis performed by the laboratory to detect residues of tetracycline and streptomycin in honey have revealed insignificant traces of oxytetracycline in two samples of honey (0.03 ppb). From the present study, it is observed that the Algerian honey samples is not completely in agreement with the requirements of international honey standards which could be caused by inappropriate actions during processing and storage steps.Key words: Honey quality, sugar, diastase activity, hydroxymethylfurfural, antibiotic residues

Application of a non-targeted approach by Flash Gas Chromatography-E-nose to discriminate the geographical origin of virgin olive oils

One of the fraudulent practices often applied in the olive oil sector concerns the mislabelling of the geographical origin of the products. In order to ensure that consumers are not mislead, the European Union issued a regulation concerning the definition of specific rules for the indication of geographical origin in the label (EU Reg. 29/2012). Beyond the compulsory traceability, the application of specific analytical techniques could be a useful tool to verify the conformity between the product and the information reported on the label. The aim of this work was to evaluate the effectiveness of a Flash Gas Chromatography-E-Nose, an instrument that combines functionality of electronic nose and ultra-fast GC, for the evaluation of the geographical origin of virgin olive oils (VOOs). For this purpose, more than 150 VOOs, different for their geographical origin (from single EU countries, such as Spain, Italy and Greece, and from single extra-EU countries, such as Tunisia, Turkey and Morocco) were collected and analyzed. Subsequently, a chemometric elaboration applied, with a non-targeted approach, to the chromatographic traces was realized. This permitted to build a model able to satisfactorily discriminate samples according to their geographical origin. This work is developed in the context of the project OLEUM \u201cAdvanced solutions for assuring authenticity and quality of olive oil at global scale\u201d, funded by the European Commission within the Horizon 2020 Programme (2014\u20132020, GA no. 635690). The information expressed in this abstract reflects the authors\u2019 views; the EC is not liable for the information contained therein

Storage time of nut spreads using flash gas chromatography E-nose combined with multivariate data analysis

The quality assessment, in terms of lipid oxidative status, of food products stored in the long-term is of great importance, especially those with a high lipid content. Specifically, companies working in this sector need feasible, simple, and fast techniques that are suitable for quality or process control. Herein, a fingerprinting approach, based on headspace analysis carried out by flash gas chromatography electronic nose (FGC E-nose) and multivariate data analysis was applied to pistachio and gianduja spreads. These samples, differently packaged, were stored in climatic chambers at 40 °C for 180 days and their headspace fraction was analyzed periodically for a total of 15 sampling times. Principal component analysis showed a clear separation according to the packaging type for both pistachio and gianduja samples. Partial least squares regression models were developed to predict the storage time considering the aggregated data (R2 up to 0.985, RMSEP = 6.16 days) or separately (R2 up to 0.989, RMSEP = 5.71 days). Based on the obtained residual prediction deviation (RPD from 4.4 to 8.5 in prediction), the models can be considered suitable for use in quality control in an industrial environment

Sensory perception and food neophobia drive liking of functional plant-based food enriched with winemaking by-products

The use of phenol compounds obtained from unripe grapes as antioxidant sustainable food ingredients is challenging due to their specific sensory attributes, such as sourness and astringency. The aim was to evaluate sensory attributes perception and consumers' liking for beetroot purees added with phenols from unripe grapes. According to hedonic responses, consumer clusters were identified and characterized for eating behavioral attitudes. Three hundred two subjects (56% women, 18–60 years old) evaluated sweet, sour, astringency, and overall flavor intensity of and liking for four beetroot puree samples added with increasing phenols concentrations (0–1.93 g/kg). Results showed that liking decreased with increasing phenols. Interestingly, samples with highest phenols concentration, characterized by sourness, and astringency, were preferred by a segment of consumers (39% of the group). This group was characterized by a low food neophobia and tended to have high emotional eating scores compared to consumers preferring samples without or with the lowest amount of extract. These results suggest that the development of functional phenol-enriched products using winemaking by-products is challenging due to their sensory properties that negatively influence consumers' acceptance. However, with appropriate segmentation strategies it is possible to identify specific consumer targets who could appreciate these new functional foods. Practical Applications: Unripe grapes can be used as a sustainable phenol source for the development of new highly antioxidant foods. Indeed, an addition till 1.9 g/kg, besides improving both the nutritional content of the food matrices, as well as promoting the reuse of winemaking by-products, could be considered feasible from a sensory point of view. Specifically, new sustainable plant-based food product, characterized by specific sensory attributes, could be target for specific groups of consumers to foster the transition to the consumption of food products developed using value-added and sustainable ingredients

Regressing multiple viral plaques and skin fragility syndrome in a cat coinfected with FcaPV2 and FcaPV3

Feline viral plaques are uncommon skin lesions clinically characterized by multiple, often pigmented, and slightly raised lesions. Numerous reports suggest that papillomaviruses (PVs) are involved in their development. Immunosuppressed and immunocompetent cats are both affected, the biological behavior is variable, and the regression is possible but rarely documented. Here we report a case of a FIV-positive cat with skin fragility syndrome and regressing multiple viral plaques in which the contemporary presence of two PV types (FcaPV2 and FcaPV3) was demonstrated by combining a quantitative molecular approach to histopathology. The cat, under glucocorticoid therapy for stomatitis and pruritus, developed skin fragility and numerous grouped slightly raised nonulcerated pigmented macules and plaques with histological features of epidermal thickness, mild dysplasia, and presence of koilocytes. Absolute quantification of the viral DNA copies (4555 copies/microliter of FcaPV2 and 8655 copies/microliter of FcaPV3) was obtained. Eighteen months after discontinuation of glucocorticoid therapy skin fragility and viral plaques had resolved.The role of the two viruses cannot be established and it remains undetermined how each of the viruses has contributed to the onset of VP; the spontaneous remission of skin lesions might have been induced by FIV status change over time due to glucocorticoid withdraw and by glucocorticoids withdraw itself