Feature space analysis for human activity recognition in smart environments

Activity classification from smart environment data is typically done employing ad hoc solutions customised to the particular dataset at hand. In this work we introduce a general purpose collection of features for recognising human activities across datasets of different type, size and nature. The first experimental test of our feature collection achieves state of the art results on well known datasets, and we provide a feature importance analysis in order to compare the potential relevance of features for activity classification in different datasets

Unsupervised grounding of textual descriptions of object features and actions in video

We propose a novel method for learning visual concepts and their correspondence to the words of a natural language. The concepts and correspondences are jointly inferred from video clips depicting simple actions involving multiple objects, together with corresponding natural language commands that would elicit these actions. Individual objects are first detected, together with quantitative measurements of their colour, shape, location and motion. Visual concepts emerge from the co-occurrence of regions within a measurement space and words of the language. The method is evaluated on a set of videos generated automatically using computer graphics from a database of initial and goal configurations of objects. Each video is annotated with multiple commands in natural language obtained from human annotators using crowd sourcing

Integrable Systems in Stringy Gravity

Static axisymmetric Einstein-Maxwell-Dilaton and stationary axisymmetric Einstein-Maxwell-Dilaton-Axion (EMDA) theories in four space-time dimensions are shown to be integrable by means of the inverse scattering transform method. The proof is based on the coset-space representation of the 4-dim theory in a space-time admitting a Killing vector field. Hidden symmetry group of the four-dimensional EMDA theory, unifying T and S string dualities, is shown to be Sp(2, R) acting transitively on the coset Sp(2, R)/U(2). In the case of two-parameter Abelian space-time isometry group, the hidden symmetry is the corresponding infinite-dimensional group of the Geroch-Kinnersley-Chitre type.Comment: 8 pages, LATEX, MSU-DTP-94/21, October 9

On the absence of scalar hair for charged rotating blackholes in non minimally coupled theories

In this work we check the validity of the no scalar hair theorem in charged axisymmetric stationary black holes for a wide class of scalar tensor theories.Comment: Revtex style, 11 pages, major rivisions done, appendix added, title change

Geroch--Kinnersley--Chitre group for Dilaton--Axion Gravity

Kinnersley--type representation is constructed for the four--dimensional Einstein--Maxwell--dilaton--axion system restricted to space--times possessing two non--null commuting Killing symmetries. New representation essentially uses the matrix--valued $SL(2,R)$ formulation and effectively reduces the construction of the Geroch group to the corresponding problem for the vacuum Einstein equations. An infinite hierarchy of potentials is introduced in terms of $2\times 2$ real symmetric matrices generalizing the scalar hierarchy of Kinnersley--Chitre known for the vacuum Einstein equations.Comment: Published in ``Quantum Field Theory under the Influence of External Conditions'', M. Bordag (Ed.) (Proc. of the International Workshop, Leipzig, Germany, 18--22 September 1995), B.G. Teubner Verlagsgessellschaft, Stuttgart--Leipzig, 1996, pp. 228-23

The Molecular Basis of Monopolin Recruitment to the Kinetochore

The monopolin complex is a multifunctional molecular crosslinker, which in S. pombe binds and organises mitotic kinetochores to prevent aberrant kinetochore-microtubule interactions. In the budding yeast S. cerevisiae, whose kinetochores bind a single microtubule, the monopolin complex crosslinks and mono-orients sister kinetochores in meiosis I, enabling the biorientation and segregation of homologs. Here, we show that both the monopolin complex subunit Csm1 and its binding site on the kinetochore protein Dsn1 are broadly distributed throughout eukaryotes, suggesting a conserved role in kinetochore organisation and function. We find that budding yeast Csm1 binds two conserved motifs in Dsn1, one (termed Box 1) representing the ancestral, widely conserved monopolin binding motif and a second (termed Box 2-3) with a likely role in enforcing specificity of sister kinetochore crosslinking. We find that Box 1 and Box 2-3 bind the same conserved hydrophobic cavity on Csm1, suggesting competition or handoff between these motifs. Using structure-based mutants, we also find that both Box 1 and Box 2-3 are critical for monopolin function in meiosis. We identify two conserved serine residues in Box 2-3 that are phosphorylated in meiosis and whose mutation to aspartate stabilises Csm1-Dsn1 binding, suggesting that regulated phosphorylation of these residues may play a role in sister kinetochore crosslinking specificity. Overall, our results reveal the monopolin complex as a broadly conserved kinetochore organiser in eukaryotes, which budding yeast have co-opted to mediate sister kinetochore crosslinking through the addition of a second, regulatable monopolin binding interface

Stationary BPS solutions to dilaton-axion gravity

Stationary four-dimensional BPS solutions to gravity coupled bosonic theories admitting a three-dimensional sigma-model representation on coset spaces are interpreted as null geodesics of the target manifold equipped with a certain number of harmonic maps. For asymptotically flat (or Taub-NUT) space-times such geodesics can be directly parametrized in terms of charges saturating the Bogomol'nyi-Gibbons-Hull bound, and classified according to the structure of related coset matrices. We investigate in detail the ``dilaton-axion gravity'' with one vector field, and show that in the space of BPS solutions an $SO(1,2) \times SO(2)$ classical symmetry is acting. Within the present formalism the most general multicenter (IWP/Taub-NUT dyon) solutions are derived in a simple way. We also discover a large new class of asymptotically flat solutions for which the dilaton and axion charges are constrained only by the BPS bound. The string metrics for these solutions are generically regular. Both the IWP class and the new class contain massless solutions.Comment: 29 pages, Latex, no figures. To be published in Phys. Rev. D. Minor grammatical and bibliographical change

12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74645/1/j.1432-2277.2006.00414.x.pd

A randomized, controlled trial of everolimus-based dual immunosuppression versus standard of care in de novo kidney transplant recipients

Kidney transplant recipients receiving calcineurin inhibitor-based immunosuppression incur increased long-term risks of cancer and kidney fibrosis. Switch to mammalian target of rapamycin (mTOR) inhibitors may reduce these risks. Steroid or Cyclosporin Removal After Transplant using Everolimus (SOCRATES), a 36-month, prospective, multinational, open-label, randomized controlled trial for de novo kidney transplant recipients, assessed whether everolimus switch could enable elimination of mycophenolate plus either steroids or CNI without compromising efficacy. Patients received cyclosporin, mycophenolate and steroids for the first 14 days then everolimus with mycophenolate and CNIwithdrawal (CNI- WD); everolimus with mycophenolate and steroid withdrawal (steroid-WD); or cyclosporin, mycophenolate and steroids (control). 126 patients were randomized. The steroid WD arm was terminated prematurely because of excess discontinuations. Mean eGFR at month 12 for CNI-WD versus control was 65.1 ml/ min/1.73 m2 vs. 67.1 ml/min/1.73 m2 by ITT, which met predefined noninferiority criteria (P = 0.026). The CNI-WD group experienced a higher rate of BPAR (31% vs. control 13%, P = 0.048) and showed a trend towards higher composite treatment failure (BPAR, graft loss, death, loss to follow-up). The 12 month results from SOCRATES show noninferiority in eGFR, but a significant excess of acute rejection when everolimus was commenced at week 2 to enable a progressive withdrawal of mycophenolate and cyclosporin in kidney transplant recipients.Steven J. Chadban, Josette Marie Eris, John Kanellis, Helen Pilmore, Po Chang Lee, Soo Kun Lim, Chad Woodcock, Nicol Kurstjens, Graeme Rus