A Functional and Lagrangian Formulation of Two-Dimensional Topological Gravity

We reconsider two-dimensional topological gravity in a functional and lagrangian framework. We derive its Slavnov-Taylor identities and discuss its (in)dependence on the background gauge. Correlators of reparamerization invariant observables are shown to be globally defined forms on moduli space. The potential obstruction to their gauge-independence is the non-triviality of the line bundle on moduli space ${\cal L}_x$, whose first Chern-class is associated to the topological invariants of Mumford, Morita and Miller. Based on talks given at the Fubini Fest, Torino, 24-26 February 1994, and at the Workshop on String Theory, Trieste, 20-22 April 1994.Comment: 11 pages, harvmac, CERN-TH-7302/94, GEF-Th-6/199

On situ vibration based structural health monitoring of a railway steel truss bridge: a preliminary numerical study

Railway network is subject to increasing travelling loads and traffic frequency. In addition, since most of the bridges were built in the last century, they are subject to ageing and degradation. It is therefore necessary to develop proper structural health monitoring systems that can support periodical visual inspections. In this context, direct monitoring systems represent an important and promising solution for structural health monitoring purposes. This paper is the result of a numerical study performed on a 3D FE bridge model based on an existing structure: the latter is a Warren truss railway bridge, located in Northern Italy, built few years after the end of the second world war. The purpose of the study is to numerically evaluate the effectiveness in damage detection and localization of different vibration-based techniques. This analysis has been performed for a set of different damage scenarios, suggested by the infrastructure managers

On the Semi-Relative Condition for Closed (TOPOLOGICAL) Strings

We provide a simple lagrangian interpretation of the meaning of the $b_0^-$ semi-relative condition in closed string theory. Namely, we show how the semi-relative condition is equivalent to the requirement that physical operators be cohomology classes of the BRS operators acting on the space of local fields {\it covariant} under world-sheet reparametrizations. States trivial in the absolute BRS cohomology but not in the semi-relative one are explicitly seen to correspond to BRS variations of operators which are not globally defined world-sheet tensors. We derive the covariant expressions for the observables of topological gravity. We use them to prove a formula that equates the expectation value of the gravitational descendant of ghost number 4 to the integral over the moduli space of the Weil-Peterson K\"ahler form.Comment: 10 pages, harvmac, CERN-TH-7084/93, GEF-TH-21/199

A Methodology for Continuous Monitoring of Rail Corrugation on Subway Lines Based on Axlebox Acceleration Measurements

Rail corrugation is a degradation phenomenon that manifests as a quasi-periodic irregularity on the running surface of the rail. It is a critical problem for urban railway lines because it induces ground-borne vibrations transmitted to the buildings near the infrastructure, causing complaints from the inhabitants. A typical treatment to mitigate the rail corrugation problem is the periodic grinding of the rails, performed by dedicated vehicles. The scheduling of rail maintenance is particularly critical because it can be performed only when the service is interrupted. A procedure for the continuous monitoring of rail corrugation is proposed, based on axlebox acceleration measurements. The rail irregularity is estimated from the measured acceleration by means of a frequency domain model of vertical dynamics of the wheel–rail interaction. The results obtained by using two different methods (a state-of-the-art method and a new one) are compared. Finally, the study of the evolution of the power content of the rail irregularity enables the identification of the track sections where corrugation is developing and rail grinding is necessary

Large Deviation Approach to the Randomly Forced Navier-Stokes Equation

The random forced Navier-Stokes equation can be obtained as a variational problem of a proper action. By virtue of incompressibility, the integration over transverse components of the fields allows to cast the action in the form of a large deviation functional. Since the hydrodynamic operator is nonlinear, the functional integral yielding the statistics of fluctuations can be practically computed by linearizing around a physical solution of the hydrodynamic equation. We show that this procedure yields the dimensional scaling predicted by K41 theory at the lowest perturbative order, where the perturbation parameter is the inverse Reynolds number. Moreover, an explicit expression of the prefactor of the scaling law is obtained.Comment: 24 page

Design for the Damping of a Railway Collector Based on the Application of Shape Memory Alloys

A new design of a Cu based SMA/GFRP lateral horn of a railway collector is proposed. Synergistic contribution of the performance parameters associated with the SMA, including specific damping, specific stiffness, and volume fraction, as well as those associated with the host composite such as flexural rigidity, SMA through-the-thickness location, and SMA-host interfacial strength, is taken into account. The aim is to increase the structural damping of the first flexural mode of the horn without significantly changing its flexural stiffness and weight. The focus of this work also applies to manufacturability and the cost effectiveness of the component for future industrial production

Anti-tumor efficacy assessment of the sigma receptor pan modulator RC-106. A promising therapeutic tool for pancreatic cancer

Introduction: Pancreatic cancer (PC) is one of the most lethal tumor worldwide, with no prognosis improvement over the past 20-years. The silent progressive nature of this neoplasia hampers the early diagnosis, and the surgical resection of the tumor, thus chemotherapy remains the only available therapeutic option. Sigma receptors (SRs) are a class of receptors proposed as new cancer therapeutic targets due to their over-expression in tumor cells and their involvement in cancer biology. The main localization of these receptors strongly suggests their potential role in ER unfolded protein response (ER-UPR), a condition frequently occurring in several pathological settings, including cancer. Our group has recently identified RC-106, a novel pan-SR modulator with good in vitro antiproliferative activities toward a panel of different cancer cell lines. In the present study, we investigated the in vitro properties and pharmacological profile of RC-106 in PC cell lines with the aim to identify a potential lead candidate for the treatment of this tumor. Methods: Pancreatic cancer cell lines Panc-1, Capan-1, and Capan-2 have been used in all experiments. S1R and TMEM97/S2R expression in PC cell lines was quantified by Real-Time qRT-PCR and Western Blot experiments. MTS assay was used to assess the antiproliferative effect of RC-106. The apoptotic properties of RC-106 was evaluated by TUNEL and caspase activation assays. GRP78/BiP, ATF4, and CHOP was quantified to evaluate ER-UPR. Proteasome activity was investigated by a specific fluorescent-based assay. Scratch wound healing assay was used to asses RC-106 effect on cell migration. In addition, we delineated the in vivo pharmacokinetic profile and pancreas distribution of RC-106 in male CD-1 mice. Results: Panc-1, Capan-1, and Capan-2 express both SRs. RC-106 exerts an antiproliferative and pro-apoptotic effect in all examined cell lines. Cells exposure to RC-106 induces the increase of the expression of ER-UPR related proteins, and the inhibition of proteasome activity. Moreover, RC-106 is able to decrease PC cell lines motility. The in vivo results show that RC-106 is more concentrated in pancreas than plasma. Conclusion: Overall, our data evidenced that the pan-SR modulator RC-106 is an optimal candidate for in vivo studies in animal models of PC

In-flight performances of the BeppoSAX γ\gamma-Ray Burst Monitor

The Italian-Dutch satellite for X-ray Astronomy BeppoSAX is successfully operating on a 600 km equatorial orbit since May 1996. We present here the in-flight performances of the Gamma Ray Burst Monitor experiment during its first year of operation. The GRBM is the secondary function of the four CsI(Na) slabs primarily operating as an active anticoincidence of the PDS hard X-ray experiment.. It has a geometric area of about 4000 cm2 but, due to its location in the core of the satellite its effective area is dependent on the energy and direction of the impinging photons. A dedicated electronics allows to trigger on cosmic gamma-ray bursts. When the trigger condition is satisfied the light curve of the event is recorded from 8 s before to 98 s after the trigger time, with a maximum time resolution of 0.48 ms, in an energy band of 40-700 keV

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Alzheimer's disease is the most common type of dementia, affecting millions of people worldwide. One of its main consequences is memory loss, which is related to downstream effectors of cyclic adenosine monophosphate (cAMP). A well-established strategy to avoid cAMP degradation is the inhibition of phosphodiesterase (PDE). In recent years, GEBR-32a has been shown to possess selective inhibitory properties against PDE type 4 family members, resulting in an improvement in spatial memory processes without the typical side effects that are usually correlated with this mechanism of action. In this work, we performed the HPLC chiral resolution and absolute configuration assignment of GEBR-32a. We developed an efficient analytical and semipreparative chromatographic method exploiting an amylose-based stationary phase, we studied the chiroptical properties of both enantiomers and we assigned their absolute configuration by 1H-NMR (nuclear magnetic resonance). Lastly, we measured the IC50 values of both enantiomers against both the PDE4D catalytic domain and the long PDE4D3 isoform. Results strongly support the notion that GEBR-32a inhibits the PDE4D enzyme by interacting with both the catalytic pocket and the regulatory domains

A call to action by the italian mesotherapy society on scientific research

: Mesotherapy (local intradermal therapy, LIT) is a technique used to slowly spread drugs in tissues underlying the site of injection to prolong the pharmacological effect with respect to intramuscular injection. Recommendations for proper medical use of this technique have been made for pain medicine and rehabilitation, chronic venous disease, sport medicine, musculoskeletal disorders, several dermatological conditions, skin ageing, and immune-prophylaxis. Although mesotherapy is considered a valid technique, unresolved questions remain, which should be answered to standardize methodology and dosing regimen as well as to define the right indications in clinical practice. New randomized controlled trials are needed to test single products (dose, frequency of administration, efficacy and safety). Even infiltration of substances for dermo-cosmetic purposes must be guided by safety and efficacy tests before being proposed by mesotherapy. In this article, we put forth a preclinical and clinical research plan and a health technology assessment as a call to action by doctors, researchers and scientific societies to aid national health authorities in considering mesotherapy for prevention, treatment and rehabilitation paths