Introduccion al estudio de la fecundidad

Incluye BibliografíaLos metodos se presentan de acuerdo a la fuente de obtencion de los datos, aquellos que provienen de estadisticas vitales y censos de poblacion y aquellos derivados exclusivamente de informacion censal. En cada caso, la presentacion analitica es ilustrada con ejemplos numericos de paises latinoamericanos. Entre los metodos, se dedican capitulos especiales al metodo de Mortara para obtener tasas de fecundidad por edad y a las tecnicas de Brass para estimar niveles recientes de fecundidad. Se agrega un apendice que muestra la evolucion de la fecundidad en los paises latinoamericanos, durante 1950-75

Efecto de la migracion en el crecimiento y la estructura de la poblacion de las ciudades de la America Latina

Incluye Bibliografí

Las estadísticas demográficas y la mortalidad en Guatemala hacia 1950 y 1964

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Comparison of HER2 status in primary and paired metastatic sites of gastric carcinoma

Background: Trastuzumab has recently shown efficacy in the treatment of HER2-positive advanced gastric adenocarcinoma. Although antibody-based therapies target the metastatic disease, HER2 status is usually evaluated in the primary tumour because metastatic sites are rarely biopsied. The aim of this study was to compare HER2 status in primary and paired metastatic sites of gastric adenocarcinoma. Methods: The HER2 status was assessed by fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) in 72 secondary lesions of gastric adenocarcinoma and in the corresponding primary tumours. Results: Concordance of FISH results, evaluable in 68 primary and matched metastatic sites, was 98.5%. Concordance of IHC results, available in 39 of the 72 paired cases, was 94.9%. Only one case showed discordance between primary tumour and metastasis, being negative by both IHC and FISH in the primary and showing HER2 overexpression and amplification in the corresponding pancreatic lymph node metastasis. Conclusion: The high concordance observed between HER2 results obtained by both IHC and FISH on primary tumours and corresponding metastases suggests that in gastric cancer HER2 status is maintained in most cases unchanged during the metastatic process. Keywords: HER2, gastric cancer, FISH, immunohistochemistr

Paraneoplastic pemphigus regression after thymoma resection

<p>Abstract</p> <p>Background</p> <p>Among human neoplasms thymomas are associated with highest frequency with paraneoplastic autoimmune diseases.</p> <p>Case presentation</p> <p>A case of a 42-year-old woman with paraneoplastic pemphigus as the first manifestation of thymoma is reported. Transsternal complete thymoma resection achieved pemphigus regression. The clinical correlations between pemphigus and thymoma are presented.</p> <p>Conclusion</p> <p>Our case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It also documents the improvement of the associated pemphigus after radical treatment of the thymoma.</p