Crotonaldehyde hydrogenation on Rh/TiO2 catalysts. In situ DRIFTS studies

The surface and catalytic properties in the vapor-phase hydrogenation of crotonaldehyde on Rh/TiO2 has been studied. It was found that a partial reduction of the support produces a surface decoration of the metal component. Thus, interfacial sites are created, which are responsible of an increase in the selectivity to crotyl alcohol, via enhancement of the polarization of the C=O bond. Photoelectron spectra revelead that rhodium is in different oxidation states, with a contribution of ca. 20 % Rhd + and 80 % Rhº species for LTR catalyst and only a slight increase of Rhd + for HTR catalyst. TEM studies revelead that Rh has metal particle size close 3 nm with small increases in the catalyst reduced at high temperature. DRIFTS essayed carried out under reaction conditions allowed to identify crotonaldehyde species strongly adsorbed through the C=C bond and weakly coordinated through both the C=C and C=O bonds. After reduction at 723 K an increase in the peak at 1660 cm-1 ascribed to an interaction between the carbonyl group and the surface, was observed. This peak seems to be stabilized at interfacial Rh/TiOx sites The deactivation in crotyl alcohol formation can be ascribed to the generation of strongly chemisorbed asymmetric carboxylate species detected by band at 1740 cm-1. This band grows at expense of crotonaldehyde O s - bonded intermediate chemisorbed on coordinatively unsaturated sites (Lewis acid sites) responsible of the crotyl alcohol obtaintion (detected by a band at 1653 cm-1). Additionally, a small band at 2068 cm-1 assigned to CO adsorbed on transition metals, which increases with time on-stream may explain the deactivation of the catalysts in flow systems

Development of A Novel Fluorescent NIR Probe for Cancer Bioimaging

Background: Optimal cancer bioimaging is imperative and come in various forms, ranging from screening to detection and surgical guidance. Current imaging tools being used are not cancer-specific and tend to expose patients to radiation. Therefore, there is a crucial need to develop newer and safer imaging modalities. Near InfraRed fluorescence (NIRF) agents have been gaining great attraction for cancer imaging in the past years, because of their high resolution/sensitivity, low cost, and real-time visualization/imaging capabilities without ionizing radiation. Hence, NIRF-based cancer imaging counterpoises some of the obstacles elicited by traditional imaging. Indocyanine green (ICG) is the only FDA approved NIR fluorescent probe for cancer imaging and image guided surgery in clinical settings. However, ICG has several limitations associated with its photostability, high concentration toxicity, and short circulation time. Additionally, internalization of ICG is not cancer-specific. To overcome this, we engineered a novel poly (vinyl pyrrolidone) (PVP) and tannic acid (TA) based nanosystem (PVT) to carry ICG to cancer cells/tissues. Methods: Pursuing the novel nanoimaging approach, our lab has developed PVP-TA-based ICG (PVT-ICG) fluorescent nanoparticles. An IVIS imaging system was used to measure NIR fluorescence of PVT-ICG and its physiochemical properties were further characterized. Moreover, human breast, pancreatic, liver, and prostate cancer cell lines, and cancer tissue microarrays (TMAs) were histochemically stained to assess cancer cell targeting/specificity of PVT-ICG. Results: PVT-ICG indicated particle size and surface charge ideal for cancer cell/tissue delivery. Furthermore, PVT-ICG demonstrated improved fluorescent intensity. Cellular and tissue-binding studies exhibited a superior cancer targeting/specificity achieved from PVT-ICG nanoparticles compared to free ICG dye in all cancer cells/TMAs Conclusion: Collectively, our findings suggest that this NIRF probe PVT-ICG has great potential for becoming a novel and safe imaging modality for various types of cancer cells and tumors which can result in early cancer diagnosis leading to improved disease management

Isolation and characterization of endosymbiotic bacteria from copper contaminated soils in Chile

Legume endosymbiotic bacteria indigenous of copper (Cu)-contaminated soils from Chile have been isolated using pea (Pisum sativum), bean (Phaseolus vulgaris) and alfalfa (Medicago sativa) as trap host plants. Highly contaminated soils only produced nodules in certain legume hosts, whereas nodulation was observed in the three legume hosts when inoculated with soils containing a low Cu concentration. A collection of 362 strains was isolated, and their levels of Cu resistance were tested in media supplemented with increasing metal concentrations and in disk diffusion assays. By these two approaches, 84 strains displaying levels of Cu resistance higher than those exhibited by the corresponding reference strains were selected. The most resistant strains isolated from alfalfa and bean nodules grew normally at 3 mM and 2.5 mM CuSO4 and were obtained from two different highly contaminated soils. Strains nodulating pea plants showed similar levels of resistance to Cu (2-2.5 mM CuSO4) and were isolated from low-contaminated soils. Our data suggest a reduction of microbial diversity in agricultural Cu-contaminated soils from Chil

Searching for optical companions to four binary millisecond pulsars with the Gran Telescopio Canarias

We report on multi-band photometric observations of four binary millisecond pulsars with the Gran Telescopio Canarias. The observations led to detection of binary companions to PSRs J1630+3734, J1741+1351 and J2042+0246 in the Sloan g', r' and i' bands. Their magnitudes in the r' band are $\approx$24.4, 24.4 and 24.0, respectively. We also set a 3$\sigma$ upper limit on the brightness of the PSR J0557+1550 companion in the r' band of $\approx$25.6 mag. Combining the optical data with the radio timing measurements and white dwarf cooling models, we show that the detected companions are cool low-mass white dwarfs with temperatures and ages in the respective ranges of (4-7)$\times 10^3$ K and 2-5 Gyr. All the detected white dwarfs are found to likely have either pure hydrogen or mixed helium-hydrogen atmospheres.Comment: Accepted for publication in MNRA

Stellar populations of galaxies in the ALHAMBRA survey up to z∼1z \sim 1. I. MUFFIT: A Multi-Filter Fitting code for stellar population diagnostics

We present MUFFIT, a new generic code optimized to retrieve the main stellar population parameters of galaxies in photometric multi-filter surveys, and we check its reliability and feasibility with real galaxy data from the ALHAMBRA survey. Making use of an error-weighted $\chi^2$-test, we compare the multi-filter fluxes of galaxies with the synthetic photometry of mixtures of two single stellar populations at different redshifts and extinctions, to provide through a Monte Carlo method the most likely range of stellar population parameters (mainly ages and metallicities), extinctions, redshifts, and stellar masses. To improve the diagnostic reliability, MUFFIT identifies and removes from the analysis those bands that are significantly affected by emission lines. We highlight that the retrieved age-metallicity locus for a sample of $z \le 0.22$ early-type galaxies in ALHAMBRA at different stellar mass bins are in very good agreement with the ones from SDSS spectroscopic diagnostics. Moreover, a one-to-one comparison between the redshifts, ages, metallicities, and stellar masses derived spectroscopically for SDSS and by MUFFIT for ALHAMBRA reveals good qualitative agreements in all the parameters. In addition, and using as input the results from photometric-redshift codes, MUFFIT improves the photometric-redshift accuracy by $\sim 10$-$20\%$, and it also detects nebular emissions in galaxies, providing physical information about their strengths. Our results show the potential of multi-filter galaxy data to conduct reliable stellar population studies with the appropiate analysis techniques, as MUFFIT.Comment: 31 pages, 18 figures, accepted for publication in A&