The Hox protein conundrum: The “specifics” of DNA binding for Hox proteins and their partners

Homeotic genes (Hox genes) are homeodomain-transcription factors involved in conferring segmental identity along the anterior-posterior body axis. Molecular characterization of HOX protein function raises some interesting questions regarding the source of the binding specificity of the HOX proteins. How do HOX proteins regulate common and unique target specificity across space and time? This review attempts to summarize and interpret findings in this area, largely focused on results from in vitro and in vivo studies in Drosophila and mouse systems. Recent studies related to HOX protein binding specificity compel us to reconsider some of our current models for transcription factor-DNA interactions. It is crucial to study transcription factor binding by incorporating components of more complex, multi-protein interactions in concert with small changes in binding motifs that can significantly impact DNA binding specificity and subsequent alterations in gene expression. To incorporate the multiple elements that can determine HOX protein binding specificity, we propose a more integrative Cooperative Binding model

Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study

The aim of this study was to evaluate the frequency of hypopituitarism following TBI in a cohort of children who had been hospitalized for mild TBI and to identify the predictive factors for this deficiency. A prospective study was conducted on children between 2 and 16 years of age who had been hospitalized for mild TBI according to the Glasgow Coma Scale between September 2009 and June 2013. Clinical parameters, basal pituitary hormone assessment at 0, 6, and 12 months, as well as a dynamic testing (insulin tolerance test) 12 months after TBI were performed. The study included 109 children, the median age was 8.5 years. Patients were examined 6 months ( = 99) and 12 months ( = 96) after TBI. Somatotropic deficiency (defined by a GH peak <20 mUI/l in two tests, an IGF-1 <-1SDS and a delta height <0SDS) were confirmed in 2 cases. One case of gonadotrophic deficiency occurred 1 year after TBI among 13 pubertal children. No cases of precocious puberty, 5 cases of low prolactin level, no cases of corticotropic insufficiency (cortisol peak <500 nmol/l) and no cases diabetes insipidus were recorded. Pituitary insufficiency was present 1year after mild TBI in about 7% of children. Based on our results, we suggest testing children after mild TBI in case of clinical abnormalities. i.e., for GH axis, IGF-1, which should be assessed in children with a delta height <0 SDS, 6 to 12 months after TBI, and a dynamic GH testing (preferentially by an ITT) should be performed in case of IGF-1 <-1SDS, with a GH threshold at 20 mUI/L. However, if a systematic pituitary assessment is not required for mild TBI, physicians should monitor children 1 year after mild TBI with particular attention to growth and weight gain

Derivation of the Zakharov equations

This paper continues the study of the validity of the Zakharov model describing Langmuir turbulence. We give an existence theorem for a class of singular quasilinear equations. This theorem is valid for well-prepared initial data. We apply this result to the Euler-Maxwell equations describing laser-plasma interactions, to obtain, in a high-frequency limit, an asymptotic estimate that describes solutions of the Euler-Maxwell equations in terms of WKB approximate solutions which leading terms are solutions of the Zakharov equations. Because of transparency properties of the Euler-Maxwell equations, this study is led in a supercritical (highly nonlinear) regime. In such a regime, resonances between plasma waves, electromagnetric waves and acoustic waves could create instabilities in small time. The key of this work is the control of these resonances. The proof involves the techniques of geometric optics of Joly, M\'etivier and Rauch, recent results of Lannes on norms of pseudodifferential operators, and a semiclassical, paradifferential calculus

Telephone speech enhancement for the hearing impaired

This thesis report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Computer Science and Engineering, 2009.Cataloged from PDF version of thesis report.Includes bibliographical references (page 48).Bony TasnimC. Z. MurshedB. Computer Science and Engineerin

Resolvent estimates for normally hyperbolic trapped sets

We give pole free strips and estimates for resolvents of semiclassical operators which, on the level of the classical flow, have normally hyperbolic smooth trapped sets of codimension two in phase space. Such trapped sets are structurally stable and our motivation comes partly from considering the wave equation for Kerr black holes and their perturbations, whose trapped sets have precisely this structure. We give applications including local smoothing effects with epsilon derivative loss for the Schr\"odinger propagator as well as local energy decay results for the wave equation.Comment: Further changes to erratum correcting small problems with Section 3.5 and Lemma 4.1; this now also corrects hypotheses, explicitly requiring trapped set to be symplectic. Erratum follows references in this versio