The detection of ultra-relativistic electrons in low Earth orbit

Aims. To better understand the radiation environment in low Earth orbit (LEO), the analysis of in-situ observations of a variety of particles, at different atmospheric heights, and in a wide range of energies, is needed. Methods. We present an analysis of energetic particles, indirectly detected by the Large Yield RAdiometer (LYRA) instrument on board ESA's Project for On-board Autonomy 2 (PROBA2) satellite as background signal. Combining Energetic Particle Telescope (EPT) observations with LYRA data for an overlapping period of time, we identified these particles as electrons with an energy range of 2 to 8 MeV. Results. The observed events are strongly correlated to geo-magnetic activity and appear even during modest disturbances. They are also well confined geographically within the L=4-6 McIlwain zone, which makes it possible to identify their source. Conclusions. Although highly energetic particles are commonly perturbing data acquisition of space instruments, we show in this work that ultra-relativistic electrons with energies in the range of 2-8 MeV are detected only at high latitudes, while not present in the South Atlantic Anomaly region.Comment: Topical Issue: Flares, CMEs and SEPs and their space weather impacts; 20 pages; 7 figures; Presented during 13th European Space Weather Week, 201

Time delays in quasi-periodic pulsations observed during the X2.2 solar flare on 2011 February 15

We report observations of quasi-periodic pulsations (QPPs) during the X2.2 flare of 2011 February 15, observed simultaneously in several wavebands. We focus on fluctuations on time scale 1-30 s and find different time lags between different wavebands. During the impulsive phase, the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) channels in the range 25-100 keV lead all the other channels. They are followed by the Nobeyama RadioPolarimeters at 9 and 17 GHz and the Extreme Ultra-Violet (EUV) channels of the Euv SpectroPhotometer (ESP) onboard the Solar Dynamic Observatory (SDO). The Zirconium and Aluminum filter channels of the Large Yield Radiometer (LYRA) onboard the Project for On-Board Autonomy (PROBA2) satellite and the SXR channel of ESP follow. The largest lags occur in observations from the Geostationary Operational Environmental Satellite (GOES), where the channel at 1-8 {\AA} leads the 0.5-4 {\AA} channel by several seconds. The time lags between the first and last channels is up to 9 s. We identified at least two distinct time intervals during the flare impulsive phase, during which the QPPs were associated with two different sources in the Nobeyama RadioHeliograph at 17 GHz. The radio as well as the hard X-ray channels showed different lags during these two intervals. To our knowledge, this is the first time that time lags are reported between EUV and SXR fluctuations on these time scales. We discuss possible emission mechanisms and interpretations, including flare electron trapping

Energy Distribution of Micro-events in the Quiet Solar Corona

Recent imaging observations of EUV line emissions have shown evidence for frequent flare-like events in a majority of the pixels in quiet regions of the solar corona. The changes in coronal emission measure indicate impulsive heating of new material to coronal temperatures. These heating or evaporation events are candidate signatures of "nanoflares" or "microflares" proposed to interpret the high temperature and the very existence of the corona. The energy distribution of these micro-events reported in the literature differ widely, and so do the estimates of their total energy input into the corona. Here we analyze the assumptions of the different methods, compare them by using the same data set and discuss their results. We also estimate the different forms of energy input and output, keeping in mind that the observed brightenings are most likely secondary phenomena. A rough estimate of the energy input observed by EIT on the SoHO satellite is of the order of 10% of the total radiative output in the same region. It is considerably smaller for the two reported TRACE observations. The discrepancy can be explained partially by different thresholds for flare detection. There is agreement on the slope and the absolute value of the distribution if the same method were used and a numerical error corrected. The extrapolation of the power law to unobserved energies that are many orders of magnitude smaller remains questionable. Nevertheless, these micro-events and unresolved smaller events are currently the best source of information on the heating process of the corona

An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction

There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report.This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper.A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible.A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research

Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform

Cancer screening; Non-small-cell lung cancerCribado de cáncer; Cáncer de pulmón de células no pequeñasCribratge de càncer; Càncer de pulmó no de cèl·lules petitesAccess to a comprehensive molecular alteration screening is patchy in Europe and quality of the molecular analysis varies. SPECTAlung was created in 2015 as a pan-European screening platform for patients with thoracic malignancies. Here we report the results of almost 4 years of prospective molecular screening of patients with thoracic malignancies, in terms of quality of the program and molecular alterations identified. Patients with thoracic malignancies at any stage of disease were recruited in SPECTAlung, from June 2015 to May 2019, in 7 different countries. Molecular tumour boards were organised monthly to discuss patients’ molecular and clinical profile and possible biomarker-driven treatments, including clinical trial options. FFPE material was collected and analysed for 576 patients with diagnosis of pleural, lung, or thymic malignancies. Ultimately, 539 patients were eligible (93.6%) and 528 patients were assessable (91.7%). The turn-around time for report generation and molecular tumour board was 214 days (median). Targetable molecular alterations were observed in almost 20% of cases, but treatment adaptation was low (3% of patients). SPECTAlung showed the feasibility of a pan-European screening platform. One fifth of the patients had a targetable molecular alteration. Some operational issues were discovered and adapted to improve efficiency.This publication was supported by Fonds Baillet Latour from Belgium and Walgreens Boots Alliance

Coronal Alfvén speed determination : consistency between seismology using AIA/SDO transverse loop oscillations and magnetic extrapolation

Two transversely oscillating coronal loops are investigated in detail during a flare on the 6th September 2011 using data from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO).We compare two independent methods to determine the Alfvén speed inside these loops. Through the period of oscillation and loop length information about the Alfvén speed inside each loop is deduced seismologically. This is compared with the Alfvén speed profiles deduced from magnetic extrapolation and spectral methods using AIA bandpass. We find that for both loops the two methods are consistent. Also, we find that the average Alfvén speed based on loop travel time is not necessarily a good measure to compare with the seismological result, which explains earlier reported discrepancies. Instead, the effect of density and magnetic stratification on the wave mode has to be taken into account. We discuss the implications of combining seismological, extrapolation and spectral methods in deducing the physical properties of coronal loops

The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing

The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV solar telescope on board ESA's Project for Onboard Autonomy 2 (PROBA2) mission launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm and provides images of the low solar corona over a 54x54 arcmin field-of-view with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is designed to monitor all space-weather-relevant events and features in the low solar corona. Given the limited resources of the PROBA2 microsatellite, the SWAP telescope is designed with various innovative technologies, including an off-axis optical design and a CMOS-APS detector. This article provides reference documentation for users of the SWAP image data.Comment: 26 pages, 9 figures, 1 movi

Diffusive Evolution of Stable and Metastable Phases II: Theory of Non-Equilibrium Behaviour in Colloid-Polymer Mixtures

By analytically solving some simple models of phase-ordering kinetics, we suggest a mechanism for the onset of non-equilibrium behaviour in colloid-polymer mixtures. These mixtures can function as models of atomic systems; their physics therefore impinges on many areas of thermodynamics and phase-ordering. An exact solution is found for the motion of a single, planar interface separating a growing phase of uniform high density from a supersaturated low density phase, whose diffusive depletion drives the interfacial motion. In addition, an approximate solution is found for the one-dimensional evolution of two interfaces, separated by a slab of a metastable phase at intermediate density. The theory predicts a critical supersaturation of the low-density phase, above which the two interfaces become unbound and the metastable phase grows ad infinitum. The growth of the stable phase is suppressed in this regime.Comment: 27 pages, Latex, eps

LUCI onboard Lagrange, the Next Generation of EUV Space Weather Monitoring

LUCI (Lagrange eUv Coronal Imager) is a solar imager in the Extreme UltraViolet (EUV) that is being developed as part of the Lagrange mission, a mission designed to be positioned at the L5 Lagrangian point to monitor space weather from its source on the Sun, through the heliosphere, to the Earth. LUCI will use an off-axis two mirror design equipped with an EUV enhanced active pixel sensor. This type of detector has advantages that promise to be very beneficial for monitoring the source of space weather in the EUV. LUCI will also have a novel off-axis wide field-of-view, designed to observe the solar disk, the lower corona, and the extended solar atmosphere close to the Sun-Earth line. LUCI will provide solar coronal images at a 2-3 minute cadence in a pass-band centred on 19.5 nm. Observations made through this pass-band allow for the detection and monitoring of semi-static coronal structures such as coronal holes, prominences, and active regions; as well as transient phenomena such as solar flares, limb Coronal Mass Ejections (CMEs), EUV waves, and coronal dimmings. The LUCI data will complement EUV solar observations provided by instruments located along the Sun-Earth line such as PROBA2-SWAP, SUVI-GOES and SDO-AIA, as well as provide unique observations to improve space weather forecasts. Together with a suite of other remote-sensing and in-situ instruments onboard Lagrange, LUCI will provide science quality operational observations for space weather monitoring

Phase III randomized trial comparing moderate-dose cisplatin to combined cisplatin and carboplatin in addition to mitomycin and ifosfamide in patients with stage IV non-small-cell lung cancer

A phase III randomized trial was conducted in patients with metastatic NSCLC, to determine if, in association with mitomycin (6 mg m–2) and ifosfamide (3 g m–2), the combination of moderate dosages of cisplatin (60 mg m–2) and carboplatin (200 mg m–2) – CarboMIP regimen – improved survival in comparison with cisplatin (50 mg m–2) alone – MIP regimen. A total of 305 patients with no prior chemotherapy were randomized, including 297 patients assessable for survival (147 in the MIP arm and 150 in the CarboMIP arm) and 268 patients assessable for response to chemotherapy. All but eight (with malignant pleural effusion) had stage IV disease. There was a 27% (95% CI, 19–34) objective response (OR) rate to MIP (25% of the eligible patients) and a 33% (95% CI, 24–41) OR rate to CarboMIP (29% of the eligible patients). This difference was not statistically significant (P = 0.34). Duration of response was not significantly different between both arms. There was also no difference (P = 0.67) in survival: median survival times were 28 weeks (95% Cl, 24–32) for MIP and 32 weeks (95% Cl, 26–35) for CarboMIP, with respectively 1-year survival rates of 24% and 23% and 2-year survival rates of 5% and 2%. The main toxicities consisted in emesis, alopecia, leucopenia and thrombocytopenia, that were, except alopecia, significantly more severe in the CarboMIP arm. Our trial failed to demonstrate a significant improvement in response or survival when patients with metastatic NSCLC were treated, in addition to ifosfamide and mitomycin, by combination of moderate dosages of cisplatin and carboplatin instead of moderate dosage of cisplatin alone. The results support the use of a moderate dose (50 mg m–2) of cisplatin in combination with ifosfamide and mitomycin for the chemotherapy of this disease. © 2000 Cancer Research Campaig