118 research outputs found
Weighted maximal regularity estimates and solvability of non-smooth elliptic systems II
We continue the development, by reduction to a first order system for the
conormal gradient, of \textit{a priori} estimates and solvability for
boundary value problems of Dirichlet, regularity, Neumann type for divergence
form second order, complex, elliptic systems. We work here on the unit ball and
more generally its bi-Lipschitz images, assuming a Carleson condition as
introduced by Dahlberg which measures the discrepancy of the coefficients to
their boundary trace near the boundary. We sharpen our estimates by proving a
general result concerning \textit{a priori} almost everywhere non-tangential
convergence at the boundary. Also, compactness of the boundary yields more
solvability results using Fredholm theory. Comparison between classes of
solutions and uniqueness issues are discussed. As a consequence, we are able to
solve a long standing regularity problem for real equations, which may not be
true on the upper half-space, justifying \textit{a posteriori} a separate work
on bounded domains.Comment: 76 pages, new abstract and few typos corrected. The second author has
changed nam
Riesz transform characterization of Hardy spaces associated with Schr\"odinger operators with compactly supported potentials
Let L=-\Delta+V be a Schr\"odinger operator on R^d, d\geq 3. We assume that V
is a nonnegative, compactly supported potential that belongs to L^p(R^d), for
some p>d/2. Let K_t be the semigroup generated by -L. We say that an
L^1(R^d)-function f belongs to the Hardy space H_L^1 associated with L if
sup_{t>0} |K_t f| belongs to L^1(R^d). We prove that f\in H_L^1 if and only if
R_j f \in L^1(R^d) for j=1,...,d, where R_j= \frac{d}{dx_j} L^{-1/2} are the
Riesz transforms associated with L.Comment: 6 page
Conical square function estimates in UMD Banach spaces and applications to H-infinity functional calculi
We study conical square function estimates for Banach-valued functions, and
introduce a vector-valued analogue of the Coifman-Meyer-Stein tent spaces.
Following recent work of Auscher-McIntosh-Russ, the tent spaces in turn are
used to construct a scale of vector-valued Hardy spaces associated with a given
bisectorial operator (A) with certain off-diagonal bounds, such that (A) always
has a bounded (H^{\infty})-functional calculus on these spaces. This provides a
new way of proving functional calculus of (A) on the Bochner spaces
(L^p(\R^n;X)) by checking appropriate conical square function estimates, and
also a conical analogue of Bourgain's extension of the Littlewood-Paley theory
to the UMD-valued context. Even when (X=\C), our approach gives refined
(p)-dependent versions of known results.Comment: 28 pages; submitted for publicatio
Boundedness of single layer potentials associated to divergence form parabolic equations with complex coefficients
Optimal Sobolev regularity for linear second-order divergence elliptic operators occurring in real-world problems
On bounded three-dimensional domains, we consider divergence-type operators including mixed homogeneous Dirichlet and Neumann boundary conditions and discontinuous coefficient functions. We develop a geometric framework in which it is possible to prove that the operator provides an isomorphism of suitable function spaces. In particular, in these spaces, the gradient of solutions turns out to be integrable with exponent larger than the space dimension three. Relevant examples from real-world applications are provided in great detail
Maximal regularity for non-autonomous equations with measurable dependence on time
In this paper we study maximal -regularity for evolution equations with
time-dependent operators . We merely assume a measurable dependence on time.
In the first part of the paper we present a new sufficient condition for the
-boundedness of a class of vector-valued singular integrals which does not
rely on H\"ormander conditions in the time variable. This is then used to
develop an abstract operator-theoretic approach to maximal regularity.
The results are applied to the case of -th order elliptic operators
with time and space-dependent coefficients. Here the highest order coefficients
are assumed to be measurable in time and continuous in the space variables.
This results in an -theory for such equations for .
In the final section we extend a well-posedness result for quasilinear
equations to the time-dependent setting. Here we give an example of a nonlinear
parabolic PDE to which the result can be applied.Comment: Application to a quasilinear equation added. Accepted for publication
in Potential Analysi
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Conical square function estimates and functional calculi for perturbed Hodge-Dirac operators in L P
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