The Lay Summary in Medical Research Proposals - is it becoming more important?

One of the skills every researcher must learn is how to present complex ideas and medical or scientific terms to a “lay” audience, for example members of the public, carers, long-term users of services, organisations representing consumers’ interests, members of the public who are the potential receipients of health promotion programmes or those from a different clinical or academic background to their own. This poster will examine: 1. What is a lay summary? A brief summary of a research project or a research proposal ... written for a lay audience , rather than researchers or professionals ... written in plain English ... avoiding the use of jargon ... explaining any technical terms. 2. The three purposes of a lay summary: • Grant and Ethical review, in particular to ensure a project is accessible by laypersons who are becoming more involved in the peer review process in some funders e.g. National Institute for Health Research – Research for Patient Benefit scheme • Public understanding of science, particularly important for fundraising charities • Raising and justifying funds from government for science to underpin improvements in healthcare 3. What should a lay summary contain? The role of the lay summary is changing, and for many funders it is clearly becoming more important, for example the Arthritis Research Campaign are putting projects to a lay audience for assessment before scientific peer review

Conclusion of Viking Lander Imaging Investigation: Picture catalog of experiment data record

The images returned by the two Viking landers during the Viking Survey Mission are presented in this report. Listing of supplemental information which describe the conditions under which the images were acquired are included. Subsets of the images are listed in a variety of sequences to aid in locating images of interest. The format and organization of the digital magnetic tape storage of the images are described. A brief description of the mission and the camera system is also included

My mother : (was the greatest gift that Daddy gave to me)

https://digitalcommons.library.umaine.edu/mmb-vp/2214/thumbnail.jp

The effects of a modest dose of alcohol on executive functioning and prospective memory

Rationale Acute alcohol intoxication selectively impairs executive functioning and prospective memory (PM). Much previous researches in this area have used laboratory-based tasks that may not mimic functions that individuals with dysexecutive syndrome have problems with in their everyday life. The present study aimed to assess the effects of a modest dose of alcohol on executive functioning and PM using a virtual reality task and investigate the role of executive planning in PM performance. Methods Forty healthy participants were administered 0.4 g/kg alcohol or matched placebo in a double-blind design. Executive function and PM were assessed using the Jansari–Agnew–Akesson–Murphy (JAAM) task, requiring participants to play the role of an office worker. Results Alcohol intoxication selectively impaired executive function and PM. The participants in the alcohol condition performed worse on the planning, prioritisation, creativity and adaptability executive subscales and also on the time-based and event-based PM tasks. However, alcohol did not impair the selection executive function task or the action-based PM task. Conclusions The results provide further support for the effects of alcohol on executive functioning and PM. In addition, the results suggest that such deficits may be present at relatively modest doses of alcohol and in the absence of a subjective feeling of intoxication Keywords: alcohol; executive functioning; prospective memory; virtual reality; memor

Wnts control membrane potential in mammalian cancer cells

The Wnt signalling network determines gene transcription with free intracellular Ca2+ (urn:x-wiley:00223751:media:tjp13863:tjp13863-math-0001) and β‐catenin as major intracellular signal transducers. Despite its critical importance during development and disease, many of the basic mechanisms of Wnt signal activation remain unclear. Here we show by single cell recording and simultaneous urn:x-wiley:00223751:media:tjp13863:tjp13863-math-0002 imaging in mammalian prostate cancer cells that an early step in the signal cascade is direct action on the cell membrane potential. We show that Wnt ligands 5A, 9B and 10B rapidly hyperpolarized the cells by activating K+ current by Ca2+ release from intracellular stores. Medium‐throughput multi‐well recordings showed responses to Wnts at concentrations of 2 nm. We identify a putative target for early events as a TRPM channel. Wnts thus act as ligands for ion channel activation in mammalian cells and membrane potential is an early indicator of control of transcription

The effects of a modest dose of alcohol on executive functioning and prospective memory

Rationale Acute alcohol intoxication selectively impairs executive functioning and prospective memory (PM). Much previous researches in this area have used laboratory-based tasks that may not mimic functions that individuals with dysexecutive syndrome have problems with in their everyday life. The present study aimed to assess the effects of a modest dose of alcohol on executive functioning and PM using a virtual reality task and investigate the role of executive planning in PM performance. Methods Forty healthy participants were administered 0.4 g/kg alcohol or matched placebo in a double-blind design. Executive function and PM were assessed using the Jansari–Agnew–Akesson–Murphy (JAAM) task, requiring participants to play the role of an office worker. Results Alcohol intoxication selectively impaired executive function and PM. The participants in the alcohol condition performed worse on the planning, prioritisation, creativity and adaptability executive subscales and also on the time-based and event-based PM tasks. However, alcohol did not impair the selection executive function task or the action-based PM task. Conclusions The results provide further support for the effects of alcohol on executive functioning and PM. In addition, the results suggest that such deficits may be present at relatively modest doses of alcohol and in the absence of a subjective feeling of intoxication

Thirty Years of Precision Electroweak Physics

We discuss the development of the theory of electroweak radiative corrections and its role in testing the Standard Model, predicting the top quark mass, constraining the Higgs boson mass, and searching for deviations that may signal the presence of new physics.Comment: 19 pages, acknowledgments added, J.J.Sakurai Prize Talk, APS Meeting, Albuquerque, N.M., April 2002. To appear in a future issue of Journal of Physics

Pyramidal micromirrors for microsystems and atom chips

Concave pyramids are created in the (100) surface of a silicon wafer by anisotropic etching in potassium hydroxide. High quality micromirrors are then formed by sputtering gold onto the smooth silicon (111) faces of the pyramids. These mirrors show great promise as high quality optical devices suitable for integration into micro-optoelectromechanical systems and atom chips. We have shown that structures of this shape can be used to laser-cool and hold atoms in a magneto-optical trap

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

This is the final version. It was first published by Wiley in The Journal of Physiology at http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.275263/abstract.Hypoxic exposure is associated with impaired cardiac energetics in humans and altered mitochondrial function, with suppressed complex I-supported respiration, in rat heart. This response might limit reactive oxygen species (ROS) generation, but at the cost of impaired electron transport chain (ETC) activity. Dietary nitrate supplementation improves mitochondrial efficiency and can promote tissue oxygenation by enhancing blood flow. We therefore hypothesised that ETC dysfunction, impaired energetics and oxidative damage in the hearts of rats exposed to chronic hypoxia could be alleviated by sustained administration of a moderate dose of dietary nitrate. Male Wistar rats (n=40) were given water supplemented with 0.7 mmol/L NaCl (as control) or 0.7 mmol/L NaNO3, elevating plasma nitrate levels by 80%, and were exposed to 13% O2 (hypoxia) or normoxia (n=10 per group) for 14 days. Respiration rates, ETC protein levels, mitochondrial density, ATP content and protein carbonylation were measured in cardiac muscle. Complex I respiration rates and protein levels were 33% lower in hypoxic/NaCl rats compared with normoxic/NaCl controls. Protein carbonylation was 65% higher in hearts of hypoxic rats compared with controls, indicating increased oxidative stress, whilst ATP levels were 62% lower. Respiration rates, complex I protein and activity, protein carbonylation and ATP levels were all fully protected in the hearts of nitrate-supplemented hypoxic rats. Both in normoxia and hypoxia, dietary nitrate suppressed cardiac arginase expression and activity and markedly elevated cardiac L-arginine concentrations, unmasking a novel mechanism of action by which nitrate enhances tissue NO bioavailability. Dietary nitrate therefore alleviates metabolic abnormalities in the hypoxic heart, improving myocardial energetics