Recovery of dialysis patients with COVID-19 : health outcomes 3 months after diagnosis in ERACODA

Background. Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods. We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results. In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions. Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis

Two 1,4-dihydropyridine derivatives with potential calcium-channel antagonist activity

The title compounds, benzyl 4-(3-chloro-2-fluorophenyl)-2-methyl-5-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carboxylate, C(23)H(19)ClFNO(3), (I), and 3-pyridylmethyl 4-[2-fluoro-3-(trifluoromethyl)phenyl]-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C(26)H(24)F(4)N(2)O(3), (II), belong to a class of 1,4-dihydropyridines whose members sometimes display calcium modulatory properties. The 1,4-dihydropyridine ring in each structure has a shallower than usual shallow-boat conformation and is nearly planar in (I). In each structure, the halogen-substituted benzene ring is oriented such that the halogen substituents are in a synperiplanar orientation with respect to the 1,4-dihydropyridine ring plane. The oxocyclopentene ring in (I) is planar, while the oxocyclohexene ring in (II) has a half-chair conformation, which is less commonly observed than the envelope conformation usually found in related compounds. In (I), the frequently observed intermolecular N-H···O hydrogen bond between the amine group and the carbonyl O atom of the oxocyclopentene ring of a neighbouring molecule links the molecules into extended chains; there are no other significant intermolecular interactions. By contrast, the amine group in (II) forms an N-H···N hydrogen bond with the pyridine ring N atom of a neighbouring molecule. Additional C-H···O interactions complete a two-dimensional hydrogen-bonded network. The halogen-substituted benzene ring has a weak intramolecular π-π interaction with the pyridine ring. A stronger π-π interaction occurs between the 1,4-dihydropyridine rings of centrosymmetrically related molecules

Variations in BARE-1 insertion patterns in barley callus cultures

The stability of aging barley calli was investigated with the barley retroelement 1 (BARE-1) retrotransposon specific inter-retrotransposon amplified polymorphism (IRAP) technique. Mature embryos of barley (Hordeum vulgare cv. Zafer-160) were cultured on callus induction MS medium supplemented with 3 mg/L 2,4-D and maintained on the same medium for 60 days. Ten IRAP primers were used in 25 different combinations. The similarity index between 30-day-old and 45-day-old calli was 84%; however, the similarity index between mature embryos and 45-day-old calli was 75%. These culture conditions caused BARE-1 retrotransposon alterations to appear as different band profiles. This is the first report of the use of the IRAP technique in barley in an investigation of callus development

Evidence of orbital forcing in lake-level fluctuations in the Middle Eocene oil shale-bearing lacustrine successions in the Mudurnu-Göynük Basin, NW Anatolia (Turkey)

Mudurnu-Göynük basin of the Sakarya Zone in NW Anatolia comprises ca. 1500. m thick Paleocene-Eocene terrestrial to shallow marine succession overlying the Late Cretaceous deeper marine progradational fore-arc sediments. Formed in a foreland setting in relation to southerly situated İzmir-Ankara suture zone, this terrestrial succession (regionally known as Ki{dotless}zi{dotless}lçay group) comprises a thin (<200. m) oil shale-bearing lacustrine section with very good cyclic patterns that potentially serves the quantification of stratigraphy and enlightening the origin of cyclicities of various hierarchy. Our detailed facies analysis on three correlative measured sections showed that mudstone, oil shale and thinner limestone alternations characterize the relatively deeper part of the Eocene lake with probable marine intervention, while thicker limestone, coal, marl and occasional oil shale alternations typify the southern relatively freshwater shoal areas. These facies are frequently organized as meter-scale symmetric to asymmetric transgressive-regressive cycles. Spectral analysis of the mudstone beds and the cycles within the lacustrine succession strongly indicates the occurrence of full bands of Milankovitch with the shortest precession cycle (19. ka) at ca. 2.30. m. Our observations further revealed quite rhythmic thin couplets with estimated durations of 365-730. yr that might represent abrupt climatic changes during deposition. On the other hand, longer duration (ca. 1. Ma) of shoaling and deepening trends in the studied sections were attributed basically to varying subsidence due to tectonic loading in the southerly suture zone. Lastly, regarding the distribution of depositional environments we propose that the oil shale exploration activities should be carried out within a 20. km wide E-W running belt while the southern limits of this belt is more prolific for coal resources. © 2012 Elsevier Ltd.Eskişehir Osmangazi Üniversitesi: 104Y153 Firat University Scientific Research Projects Management UnitThis paper is based on the findings of a scientific Project with the Number 200715024 supported by the Commission for Scientific Research Projects of the Eskişehir Osmangazi University, Eskişehir, Turkey. Logistic support is also provided by another Project (No: 104Y153) from TUBİTAK

Synthesis of Cyclopentapyridine and Thienopyridine derivatives as potential calcium channel modulators

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators