655 research outputs found
FESD: a Functional Element SNPs Database in human
We have created the Functional Element SNPs Database (FESD) that categorizes functional elements in human genic regions and provides a set of single nucleotide polymorphisms (SNPs) located within each area. In the FESD, the human genic regions were divided into 10 different functional elements, such as promoter regions, CpG islands, 5′-untranslated regions (5′-UTRs), translation start sites, splice sites, coding exons, introns, translation stop sites, polyadenylation signals and 3′-UTRs, and subsequently, all the known SNPs were assigned to each functional element at their respective position. With the FESD web interface, users can select a set of SNPs in the specific functional elements and get their flanking sequences for genotyping experiments, which will help in finding mutations that contribute to the common and polygenic diseases. A web interface for the FESD is freely available at http://combio.kribb.re.kr/ksnp/resd/
Physical properties of transparent perovskite oxides (Ba,La)SnO3 with high electrical mobility at room temperature
Transparent electronic materials are increasingly in demand for a variety of
optoelectronic applications. BaSnO3 is a semiconducting oxide with a large band
gap of more than 3.1 eV. Recently, we discovered that La doped BaSnO3 exhibits
unusually high electrical mobility of 320 cm^2(Vs)^-1 at room temperature and
superior thermal stability at high temperatures [H. J. Kim et al. Appl. Phys.
Express. 5, 061102 (2012)]. Following that work, we report various physical
properties of (Ba,La)SnO3 single crystals and films including
temperature-dependent transport and phonon properties, optical properties and
first-principles calculations. We find that almost doping-independent mobility
of 200-300 cm^2(Vs)^-1 is realized in the single crystals in a broad doping
range from 1.0x10^19 to 4.0x10^20 cm^-3. Moreover, the conductivity of ~10^4
ohm^-1cm^-1 reached at the latter carrier density is comparable to the highest
value. We attribute the high mobility to several physical properties of
(Ba,La)SnO3: a small effective mass coming from the ideal Sn-O-Sn bonding,
small disorder effects due to the doping away from the SnO2 conduction channel,
and reduced carrier scattering due to the high dielectric constant. The
observation of a reduced mobility of ~70 cm^2(Vs)^-1 in the film is mainly
attributed to additional carrier-scatterings which are presumably created by
the lattice mismatch between the substrate SrTiO3 and (Ba,La)SnO3. The main
optical gap of (Ba,La)SnO3 single crystals remained at about 3.33 eV and the
in-gap states only slightly increased, thus maintaining optical transparency in
the visible region. Based on these, we suggest that the doped BaSnO3 system
holds great potential for realizing all perovskite-based, transparent
high-frequency high-power functional devices as well as highly mobile
two-dimensional electron gas via interface control of heterostructured films.Comment: 31 pages, 7 figure
Performance-Based Multiobjective Optimal Seismic Retrofit Method for a Steel Moment-Resisting Frame Considering the Life-Cycle Cost
This study proposes a performance-based multiobjective optimization seismic retrofit method for steel moment-resisting frames. The brittle joints of pre-Northridge steel moment-resisting frames are retrofitted to achieve ductility; the method involves determining the position and number of connections to be retrofitted. The optimal solution is determined by applying the nondominated sorting genetic algorithm-II (NSGA-II), which acts as a multiobjective seismic retrofit optimization technique. As objective functions, the initial cost for the connection retrofit and lifetime seismic damage cost were selected, and a seismic performance level below the 5% interstory drift ratio was employed as a constraint condition. The proposed method was applied to the SAC benchmark three- and nine-story buildings, and several Pareto solutions were obtained. The optimized retrofit solutions indicated that the lifetime seismic damage cost decreased as the initial retrofit cost increased. Although every Pareto solution existed within a seismic performance boundary set by a constraint function, the seismic performance tended to increase with the initial retrofit cost. Analysis and economic assessment of the relations among the initial retrofit cost, lifetime seismic damage cost, total cost, and seismic performance of the derived Pareto solution allow building owners to make seismic retrofit decisions more rationally
High Mobility in a Stable Transparent Perovskite Oxide
We discovered that La-doped BaSnO3 with the perovskite structure has an
unprecedentedly high mobility at room temperature while retaining its optical
transparency. In single crystals, the mobility reached 320 cm^2(Vs)^-1 at a
doping level of 8x10^19 cm^-3, constituting the highest value among
wide-band-gap semiconductors. In epitaxial films, the maximum mobility was 70
cm^2(Vs)^-1 at a doping level of 4.4x10^20 cm^-3. We also show that resistance
of (Ba,La)SnO3 changes little even after a thermal cycle to 530 Deg. C in air,
pointing to an unusual stability of oxygen atoms and great potential for
realizing transparent high-frequency, high-power functional devices.Comment: 15 pages, 3 figure
A comparison of the effectiveness of QuEChERS, FaPEx and a modified QuEChERS method on the determination of organochlorine pesticides in ginseng
This study provides a review of methods used in the determination of organochlorine pesticides (OCPs) in ginseng and compares the effectiveness of three extraction methods (Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS), a modified QuEChERS and a Fast Pesticide Extraction (FaPEx)) in the analyses of 20 OCPs in ginseng root samples. For each method, sample mass, solvent volume and sorbent mass were varied to identify the optimum combination to effectively isolate analytes of interest from the complex sample matrix. Extracts were analyzed using the gas chromatography-μ-electron capture detector (GC-μ-ECD), and confirmatory analyses performed by gas chromatography-tandem-mass spectrometry (GC-MS/MS). Eighteen out of 20 OCPs spiked onto in-house prepared ginseng samples produced acceptable recoveries (51–156%) when extracted using QuEChERS and FaPEx. All 20 analytes, including dichlorodiphenyldichloroethane (p, p’- DDD) and dichlorodiphenyltrichloroethane (o, p’-DDT), produced acceptable recoveries (51–129%) with the use of a modified QuEChERS method. The applicability of the modified QuEChERS method was demonstrated through the analysis of ginseng samples grown in endosulfan-treated soil. The samples were analyzed by both GC-μ-ECD and GC-MS/MS with no significant difference identified in the results of each analytical method. This study highlights the applicability of the modified QuEChERS method, in combination with GC- μ-ECD, to determine organochlorine pesticides in ginseng. This may be especially useful for laboratories in developing countries and less advanced institutions without access to MS/MS instrumentation
Incidentally Discovered a Self-Inflicted a Nail in the Brain of Schizophrenia Patient
The self-infliction of foreign bodies into the brain represents rare a clinical phenomenon that has been reported primarily in cases involving accidents and suicide attempts. However, various motivations for self-injurious behaviors as well as suicide attempts have been reported, especially in patients with psychotic illnesses. A 47-year-old man with a history of schizophrenia presented to our hospital due to the presence of a nail on his plain skull X-ray. He diagnosed paranoid type of schizophrenia about 17 years earlier, and his psychiatric symptoms were well controlled by medication. Interestingly, he was not aware of the presence of the nail in his brain and showed no neurological deficits. In the course of detailed history taking, we discovered that the nail was driven into his brain during a hallucinatory experience that had occurred more than 10 years earlier. Because we believed that removing the nail from his brain would be more dangerous than maintaining the status quo, the nail was not removed. This is a very rare case of a self-inflicted injury involving inserting a nail into the brain under the influence of hallucinations. The absence of adverse effects or neurological symptoms/signs related to the presence of a foreign metallic body in the brain for over 10 years is exceptional
Teatro e ensino da matemática: atividade desenvolvida num curso de formação docente
Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014Este trabalho relata uma aula desenvolvida pelas alunas do Curso de Formação de Docentes
do Instituto Estadual de Educação de Londrina com a colaboração dos Bolsistas do Programa
Institucional de Bolsas de Iniciação à Docência – PIBID – Subprojeto de Matemática, para alunos de
primeiro ano do Ensino Fundamental utilizando o teatro como forma de apresentar conteúdos
matemáticos como números, sequência de números, operações básicas como adição, subtração e
conteúdos de lÃngua portuguesa como leitura e escrita de número
- …