Clinicopathological Features of Extranodal Lymphomas: 15 Years' Experience of a Single Center

Objective: In this study, we aimed to evaluate the localization and histopathological diagnosis, and clinicopathologic characteristics of primary extranodal lymphomas. Methods: The pathology reports between 2001 and 2015 in the archives of Uludag University Faculty of Medicine Pathology Department were reviewed and all cases with an extranodal lymphoma diagnosis were analyzed. The information about the diagnosis, tumor localization, symptoms at presentation, presence of B symptoms, lymphocytosis and anemia, chronic infection and chronic disease and concomitant secondary malignancy, tumor diameter, the involvement of another extranodal organ, lymph node, bone marrow, spleen, liver, stage of the disease, serum B2 microglobulin, LDH, albumin levels, sedimentation rate were documented. The localization, histopathological types, age groups, male/female ratios in cases of primary extranodal lymphoma were evaluated. Results: Total sum of 1743 patients were diagnosed with lymphoma. 480 (%27,53) of these cases were extranodal lymphomas. The most commonly encountered locations of extranodal lymphomas were the skin and the gastrointestinal system. There were 226 primary extranodal skin, 90 gastrointestinal system, 44 central nervous system, 8 genitourinary system, 50 head and neck, 18 musculoskeletal system and soft tissue, 9 mediastinum, 3 bronchus, 10 orbital, 2 liver, 6 pancreas, 4 omentum, 8 endocrine system, and 2 breast located cases. 237 of the primary extranodal lymphomas from our work were mature T/NK celled neoplasias. There were 250 patients with mature B cell lymphoma, 5 cases of Hodgkin lymphoma, and 5 cases of precursor lymphoid neoplasia. Conclusions: The data from our series were coherent with the literature. Due to the small number of cases with some localization and some histopathological diagnosis, no significant results could be reached about these entities.WOS:00068972950001

EFFECT OF LINOPIRDINE ON FORCED SWIMMING TEST IN RATS

WOS: 000467534400006Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats. Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 mu l) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 mu g/4 mu l) intracerebroventricularly (i.c.v.), 15 min before the test. Results: Linopirdine at a dose of 0.1 mu g/4 mu l significantly decreased immobilisation (p=0.003) and significantly increased swimming (p<0.01) with respect to the control grup. Linopirdine at the doses of 1 mu g/4 mu l and 10 mu g/4 mu l; i.c.v., significantly decreased immobilisation (p values<0.001) and significantly increased swimming (p=0.003 and p=0.021, respectively), and climbing (p=0.009 and p=0.006, respectively) with respect to the control grup. Conclusion: The results we obtained shows that linopirdine applied through i.c.v way produces similar effects as the anti-depressant drugs in the FST model. Therefore, we believe that drugs that block Kv7 type voltage-gated potassium channels can be considered as antidepressant drug targets

Peripheral Blood Lymphocyte Dynamics and Viral Kinetics in Patients with Chronic Active Hepatitis B Virus Infection Treated by Tenofovir

WOS: 000304683800045PubMed: 22193343Background/Aims: We investigated serum viral kinetics and peripheral blood lymphocyte dynamics in chronic hepatitis B patients during the first year of tenofovir therapy. Methodology: Fifteen patients, naive to any kind of previous antiviral therapy, were included in this study. The patients received tenofovir daily 245mg for 48 weeks. Fifteen age and gender compatible healthy subjects were enrolled as the control group. Clinical, biochemical, immunological and virological parameters were assessed at baseline, then at the first, third, sixth and twelfth months. Results: CD4(+)CD25(+)FOXP3(+) nTregs percentages were significantly higher in the study group than that of healthy controls, CD4(+)CD28(+) and CD4(+)CD38(+) T cell percent-ages were significantly lower in the study group than those of control group (p<0.001). Twelve cases had undetectable HBV DNA levels after the one year therapy. We determined that there was an increase of the CD28(+)co-stimulator molecule on both the CD4(+) and CD8(+) T cells while a decrease of the CD8(+)CD38(+) T cells, CD4(+)CD38(+) T cells and CD4(+)CD25(+)FOXP3(+) nTregs, in patients with tenofovir treatment, but only CD4(+)CD25(+)FOXP3(+) nTregs were statistically significant. Conclusions: We found that both viral load and CD4(+)CD25(+)FOXP3(+) nTreg percentages decreased significantly in patients with chronic hepatitis B virus infection during 1 year course of tenofovir treatment

EFFECT OF LINOPIRDINE ON FORCED SWIMMING TEST IN RATS

WOS: 000467534400006Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats. Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 mu l) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 mu g/4 mu l) intracerebroventricularly (i.c.v.), 15 min before the test. Results: Linopirdine at a dose of 0.1 mu g/4 mu l significantly decreased immobilisation (p=0.003) and significantly increased swimming (p<0.01) with respect to the control grup. Linopirdine at the doses of 1 mu g/4 mu l and 10 mu g/4 mu l; i.c.v., significantly decreased immobilisation (p values<0.001) and significantly increased swimming (p=0.003 and p=0.021, respectively), and climbing (p=0.009 and p=0.006, respectively) with respect to the control grup. Conclusion: The results we obtained shows that linopirdine applied through i.c.v way produces similar effects as the anti-depressant drugs in the FST model. Therefore, we believe that drugs that block Kv7 type voltage-gated potassium channels can be considered as antidepressant drug targets

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study (vol 37, pg 104, 2013)

WOS: 00032225650000

Erratum: Optical coherence tomography in patients with relapsing-remitting multiple sclerosis without optic neuritis: A 20-month longitudinal study (Neuro-Ophthalmology (2013) 37 (104-110))

[No abstract available

Does Weight Gain During the Operation Wait Time Have an Impact on Weight Loss After Laparoscopic Sleeve Gastrectomy?

Weight gain during waiting time has no negative impact on % weight loss and % BMI loss after SG

Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations

WOS: 000381062200009PubMed: 27386634OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy

Evaluation of atrial electromechanical delay and left atrial mechanical function in patients with obstructive sleep apnea Cardiac involvement in patients with OSA

The aim of this study was to evaluate atrial electromechanical delay measured by tissue Doppler imaging and left atrial mechanical function in patients with obstructive sleep apnea (OSA)

Assessment of left atrial mechanical functions in thyroid dysfunction

INTRODUCTION Thyroid hormone deficiency can lead to the impairment of cardiac function