Reforming the cancer drug fund focus on drugs that might be shown to be cost effective

The Cancer Drug Fund was originally conceived as a temporary measure, until value based pricing for drugs was introduced, to give NHS cancer patients access to drugs not approved by NICE. Spending on these drugs rose from less than the £50m (€63m; $79m) budgeted for the first year in 2010-11 to well over £200m in 2013-14, and the budget for the scheme—now extended for a further two years—will reach £280m by 2016.1 The recent changes to the fund recognise the impossibility, within any sensible budget limit, of providing all the new cancer drugs that offer possible benefit to patients. More radical changes are needed to the working of the fund, given the failure to introduce value based pricing, so that it deals with the underlying problem of inadequate information on the effectiveness and cost effectiveness of new cancer drugs when used in the NHS

Exploring Preferences for Urban Greening in Association with Learning About Sustainability in a Museum-based Urban Ecology Exhibit

Sustainable urban design and planning is grounded in understanding complex interconnecting relationships between human and ecological processes (Alberti & Marzluff, 2004). While compulsory education may provide an introduction to this subject, supplementary means are necessary in order to support citizen knowledge, interest and understanding of these complex relationships. Informal learning settings, such as museums, create opportunities for lifelong learning (Falk and Dierking, 2010) and can introduce, incorporate and link urban sustainability issues to provide an accessible and engaging introduction to the subject. Sustainable responses to urban development point to the need for higher density neighbourhoods coupled with extensive urban tree canopy (Alberti & Marzluff, 2004). However, more research is needed to ascertain if these urban forms match the preferred settings of urban residents. A family science museum provides a unique setting to explore urban greening in residential settings and provides museum visitors with the opportunity to participate in social-science research

79. The Modern Pottery Industry in Malta.

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Exploring Preferences for Urban Greening

Sustainable responses to urban development point to the need for higher density neighborhoods coupled with extensive urban tree canopy and greening. However, little research has been conducted with urban residents to ascertain if these urban forms match their preferred setting. This study sought to understand whether higher levels of greening could moderate preference for lower density residential settings when 212 participants rated images for preference. Each of the independent variables, greening and density, made a difference in preference: greener settings were more preferred than less green settings overall, and perceived density was marginally significant in relation to preference. A factor analysis resulted in the grouping of five neighborhood types distinguished by certain characteristics (e.g., greening, buffer, building form) which, together with the qualitative responses suggested insights for making higher density residential environments more preferred. We did not find a significant interaction between greening and perceived density in relation to preference, suggesting that greening does not moderate the density-preference relation

Changes in Exercise Data Management

The suite of exercise hardware aboard the International Space Station (ISS) generates an immense amount of data. The data collected from the treadmill, cycle ergometer, and resistance strength training hardware are basic exercise parameters (time, heart rate, speed, load, etc.). The raw data are post processed in the laboratory and more detailed parameters are calculated from each exercise data file. Updates have recently been made to how this valuable data are stored, adding an additional level of data security, increasing data accessibility, and resulting in overall increased efficiency of medical report delivery. Questions regarding exercise performance or how exercise may influence other variables of crew health frequently arise within the crew health care community. Inquiries over the health of the exercise hardware often need quick analysis and response to ensure the exercise system is operable on a continuous basis. Consolidating all of the exercise system data in a single repository enables a quick response to both the medical and engineering communities. A SQL server database is currently in use, and provides a secure location for all of the exercise data starting at ISS Expedition 1 - current day. The database has been structured to update derived metrics automatically, making analysis and reporting available within minutes of dropping the inflight data it into the database. Commercial tools were evaluated to help aggregate and visualize data from the SQL database. The Tableau software provides manageable interface, which has improved the laboratory's output time of crew reports by 67%. Expansion of the SQL database to be inclusive of additional medical requirement metrics, addition of 'app-like' tools for mobile visualization, and collaborative use (e.g. operational support teams, research groups, and International Partners) of the data system is currently being explored

The Evolution of Exercise Hardware on ISS: Past, Present, and Future

During 16 years in low-Earth orbit, the suite of exercise hardware aboard the International Space Station (ISS) has matured significantly. Today, the countermeasure system supports an array of physical-training protocols and serves as an extensive research platform. Future hardware designs are required to have smaller operational envelopes and must also mitigate known physiologic issues observed in long-duration spaceflight. Taking lessons learned from the long history of space exercise will be important to successful development and implementation of future, compact exercise hardware. The evolution of exercise hardware as deployed on the ISS has implications for future exercise hardware and operations. Key lessons learned from the early days of ISS have helped to: 1. Enhance hardware performance (increased speed and loads). 2. Mature software interfaces. 3. Compare inflight exercise workloads to pre-, in-, and post-flight musculoskeletal and aerobic conditions. 4. Improve exercise comfort. 5. Develop complimentary hardware for research and operations. Current ISS exercise hardware includes both custom and commercial-off-the-shelf (COTS) hardware. Benefits and challenges to this approach have prepared engineering teams to take a hybrid approach when designing and implementing future exercise hardware. Significant effort has gone into consideration of hardware instrumentation and wearable devices that provide important data to monitor crew health and performance

Ground State Properties of Anderson Impurity in a Gapless Host

Using the Bethe ansatz method, we study the ground state properties of a $U\to\infty$ Anderson impurity in a ``gapless'' host, where a density of band states vanishes at the Fermi level $\epsilon_F$ as $|\epsilon-\epsilon_F|$. As in metals, the impurity spin is proven to be screened at arbitrary parameters of the system. However, the impurity occupancy as a function of the bare impurity energy is shown to acquire novel qualitative features which demonstrate a nonuniversal behavior of the system. The latter explains why the Kondo screening is absent (or exists only at quite a large electron-impurity coupling) in earlier studies based on scaling arguments.Comment: 5 pages, no figure, RevTe

Makerspaces and the Characteristics of Effective Learning for peer review (CoELs) in the early years

The global growth of makerspaces, focusing on STEM (Science, Technology, Engineering, Mathematics) disciplines, supports participatory child-centred learning and fosters essential skills in areas such as creativity, critical thinking, and collaboration. We argue that establishing a makerspace pedagogy in schools fosters children’s engagement in digital/technological learning in a way that is in-keeping with the creative practices of the early years. This paper reports on findings from a research project that took place in one local authority in the north of England focusing on the educational implications of makerspace participation for young children and teachers. The project explored children and teacher engagement with a ‘MakerBox’ containing a story sack, language and maths activities and maker activities in 17 early years classrooms (Nursery and Reception). As a way of recording children’s learning we devised the Makerspace Learning Assessment Framework (MLAF) based on the Characteristics of Effective Learning (CoEL). This framework has been developed as a way of supporting teachers to assess children’s skills, knowledge and understanding when participating in makerspaces in a child-centred and holistic way. Through interviews with teachers, we explored their perception of the educational implications of makerspaces for children’s learning and their own professional development. Our findings indicate that engagement in makerspaces enhances children’s learning experiences as evidenced by the CoEL and positively impacts teachers’ STEM knowledge and practice. We conclude that makerspaces offer an holistic, child-centred approach to learning and skill development, aligning with early years creative practice and teacher professional growth

The Effects of Ketone Supplementation on Recovery in Collegiate Male Soccer Players: Pilot Trial

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