Polarization switching and induced birefringence in InGaAsP multiple quantum wells at 1.5 mu m

We analyze the 1.5mum wavelength operation of a room temperature polarization switch based on electron spin dynamics in InGaAsP multiple quantum wells. An unexpected difference in response for left and right circularly polarized pump light in pump-probe measurements was discovered and determined to be caused by an excess carrier induced birefringence. Transient polarization rotation and ellipticity were measured as a function of time delay. (C) 2002 American Institute of Physics.</p

Physical literacy: Importance, assessment and future directions

Physical literacy (PL) has become a major focus of physical education, physical activity and sports promotion worldwide. PL is a multifaceted conceptualisation of the skills required to fully realise potentials through embodied experience. Substantial financial investments in PL education by governments are underpinned by a wide range of anticipated benefits, including expectations of significant future savings to healthcare, improved physical and psychological well-being of the population, increased work-force productivity and raised levels of expertise in sport and exercise participation. However, disappointingly, scientific evidence showing the efficacy of PL interventions to successfully meet such high expectation is limited. We suggest that contradictions in research findings are due largely to limitations in movement assessment batteries and consequent discrepancies between measurements used to assess the immediate outcomes of PL programmes. Notably, there is no robust empirical tool for evidencing skill learning in the physical movement component of PL, education and this presents a serious limitation to the design of, and claims that can be made for, such interventions. Considering the parameters of proficient PL skills and the limitations of current evaluation instruments, possible future directions for developing empirical measures of PL movement skills are presented

Frequency domain model for analysis of paralleled, series-output-connected Mapham inverters

The Mapham resonant inverter is characterized as a two-port network driven by a selected periodic voltage. The two-port model is then used to model a pair of Mapham inverters connected in series and employing phasor voltage regulation. It is shown that the model is useful for predicting power output in paralleled inverter units, and for predicting harmonic current output of inverter pairs, using standard power flow techniques. Some examples are compared to data obtained from testing hardware inverters

Groundwater reinjection and heat dissipation: lessons from the operation of a large groundwater cooling system in Central London

The performance of a large open-loop groundwater cooling scheme in a shallow alluvial aquifer at a prominent public building in Central London has been monitored closely over its first 2 years of operation. The installed system provided cooling to the site continuously for a period of 9 months between June 2012 and April 2013. During this period, c. 131300 m3 of groundwater was abstracted from a single pumping well and recharged into a single injection borehole. The amount of heat rejected in this period amounts to c. 1.37 GWh. A programme of hydraulic testing was subsequently undertaken over a 3 month period between July and October 2013 to evaluate the performance of the injection borehole. The data indicate no significant change in injection performance between commissioning trials undertaken in 2010 and the most recent period of testing, as evidenced by comparison of injection pressures for given flow rates in 2010 and 2013. Continuous temperature monitoring of the abstracted water, the discharge and a number of observation wells demonstrates the evolution of a heat plume in the aquifer in response to heat rejection and subsequent dissipation of this heat during the 18 month planned cessation

Distortion and regulation characterization of a Mapham inverter

Output voltage Total Harmonic Distortion (THD) of a 20kHz, 6kVA Mapham resonant inverter is characterized as a function of its switching-to-resonant frequency ratio, f sub s/f sub r, using the EASY5 engineering analysis system. EASY5 circuit simulation results are compared with hardware test results to verify the accuracy of the simulations. The effects of load on the THD versus f sub s/f sub r ratio is investigated for resistive, leading, and lagging power factor load impedances. The effect of the series output capacitor on the Mapham inverter output voltage distortion and inherent load regulation is characterized under loads of various power factors and magnitudes. An optimum series capacitor value which improves the inherent load regulation to better than 3 percent is identified. The optimum series capacitor value is different than the value predicted from a modeled frequency domain analysis. An explanation is proposed which takes into account the conduction overlap in the inductor pairs during steady-state inverter operation, which decreases the effective inductance of a Mapham inverter. A fault protection and current limit method is discussed which allows the Mapham inverter to operate into a short circuit, even when the inverter resonant circuit becomes overdamped

Intimate partner homicide in England and Wales 2011-2013: pathways to prediction from multi-agency Domestic Homicide Reviews

Research Question What pathways to more accurate prediction of intimate partner homicide (IPH) can be found by reviewing two years of official Domestic Homicide Reviews in England and Wales? Data This study conducted a detailed review of investigative source material, police database information and the official independent author reviews of the 188 cases of intimate partner homicide recorded in England and Wales between April 2011 and March 2013. Methods Descriptive analytical techniques were used to explore the prevalence of various characteristics of victims, offenders and relationships in these cases, with special attention given to offender suicide ideation as a precursor to the crimes. Findings Offenders in these cases were 86% male, with high rates of both chronic substance abuse (61%) and prior reported offending (50%) against their homicide victim. The most disproportionately prevalent characteristic appears to be that 40% of the male offenders were known by someone, but often not to police, as suffering suicidal ideation, self-harm or attempted suicides. The prevalence of that marker, while not measureable in the general population, is over four times higher than the pre-offence police indications of suicidal tendencies across 80 domestic homicides in Leicestershire (Button et al., 2017). Conclusions It is plausible that many more intimate partner homicides might be accurately predicted, and perhaps prevented, with more public investment in obtaining data on suicidal indicators and more proactive treatment of domestic abuse offenders known to suffer suicidal tendencies.Non

Autophagic activity in neuronal cell death.

As post-mitotic cells with great energy demands, neurons depend upon the homeostatic and waste-recycling functions provided by autophagy. In addition, autophagy also promotes survival during periods of harsh stress and targets aggregate-prone proteins associated with neurodegeneration for degradation. Despite this, autophagy has also been controversially described as a mechanism of programmed cell death. Instances of autophagic cell death are typically associated with elevated numbers of cytoplasmic autophagosomes, which have been assumed to lead to excessive degradation of cellular components. Due to the high activity and reliance on autophagy in neurons, these cells may be particularly susceptible to autophagic death. In this review, we summarize and assess current evidence in support of autophagic cell death in neurons, as well as how the dysregulation of autophagy commonly seen in neurodegeneration can contribute to neuron loss. From here, we discuss potential treatment strategies relevant to such cell-death pathways.DCR is funded by a Wellcome Trust Principal Research Fellowship and the NIHR Biomedical Research Unit in Dementia at Addenbrooke’s Hospital. This review is supported by Plymouth University and Northcott Medical Foundation.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s12264-015-1528-

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype

Abnormalities in mucus production and qualitative properties such as mucus hydration are central to the pathophysiology of airway disease including cystic fibrosis, asthma, and chronic bronchitis. In vitro air–liquid interface epithelial cell cultures demonstrate direct relationships between mucociliary transport, periciliary liquid (PCL) height, and mucus concentration (expressed as percent solids or partial osmotic pressure). In health, the osmotic modulus/pressure of the PCL exceeds that of the mucus layer, resulting in efficient, low-friction movement of mucus. In disease, through multiple mechanisms, the osmotic pressure of the mucus begins to exceed basal PCL values, resulting in compression of the cilia and slowing of mucus transport. The in vivo data in both cystic fibrosis and chronic bronchitis parallel in vitro data demonstrating that when mucus osmotic pressure is increased, mucociliary clearance is decreased. In chronic bronchitis, there is a direct correlation between FEV1 and percent solids of mucus, demonstrating a strong relationship between disease progression and mucus abnormalities. Animal models, based mechanistically on raised sodium absorption (and therefore water absorption) from airway surfaces, mimic the pathophysiology of chronic obstructive pulmonary disease. Collectively, these data suggest the importance of mucus concentration in the pathogenesis of airway disease. It is important to understand the precise mechanisms that result in mucus hyperconcentration, for example, mucin overproduction versus abnormal regulation of ion/water transport, which may be unique to and characteristic of each disease phenotype. The measurement of mucus concentration may be a simple method to diagnose chronic bronchitis, monitor its progression, and serve as a biomarker for development of new therapies

Inter-similarity between coupled networks

Recent studies have shown that a system composed from several randomly interdependent networks is extremely vulnerable to random failure. However, real interdependent networks are usually not randomly interdependent, rather a pair of dependent nodes are coupled according to some regularity which we coin inter-similarity. For example, we study a system composed from an interdependent world wide port network and a world wide airport network and show that well connected ports tend to couple with well connected airports. We introduce two quantities for measuring the level of inter-similarity between networks (i) Inter degree-degree correlation (IDDC) (ii) Inter-clustering coefficient (ICC). We then show both by simulation models and by analyzing the port-airport system that as the networks become more inter-similar the system becomes significantly more robust to random failure.Comment: 4 pages, 3 figure

Effects of Superpave restricted zone on permanent deformation

The purpose of this study is to evaluate the restricted zone effect using four different aggregates: crushed granite, crushed limestone, crushed river gravel, and a mixture of crushed river gravel as coarse aggregate with natural fines. As the restricted zone is a component of Superpave, the blends prepared met most of the Superpave criteria, except the restricted zone in selected mixtures and fine aggregate angularity in three mixtures. Each type of aggregate was used for mixture design of three gradations: above, through, and below the restricted zone. The twelve mixtures designed were tested in the laboratory to evaluate their relative resistance to permanent deformation. Four types of tests were performed using Superpave equipment: simple shear at constant height, frequency sweep at constant height, repeated shear at constant stress ratio, and repeated shear at constant height. Rutting resistance of the mixtures was measured using the Asphalt Pavement Analyzer.Aggregates Foundation for Technology, Research, and Education (AFTRE)Civil, Architectural, and Environmental Engineerin