Mission Services Evolution Center Message Bus

The Goddard Mission Services Evolution Center (GMSEC) Message Bus is a robust, lightweight, fault-tolerant middleware implementation that supports all messaging capabilities of the GMSEC API. This architecture is a distributed software system that routes messages based on message subject names and knowledge of the locations in the network of the interested software components

Neural Basis of Smoking-Induced Relief of Craving and Negative Affect: Contribution of Nicotine

Smoking-induced relief of craving and withdrawal promotes continued cigarette use. Understanding how relief is produced and the role of nicotine in this process may facilitate development of new smoking-cessation therapies. As the US Food and Drug Administration considers setting a standard for reduced nicotine content in cigarettes to improve public health, knowledge of how nicotine contributes to relief also can inform policy. We assessed effects of nicotine using resting state functional magnetic resonance imaging (MRI) and behavioral assessments of craving and negative affect. Twenty-one young (18-25 years old) daily smokers underwent overnight abstinence on 4 days. On each of the following mornings, they self-rated their cigarette craving and negative affect and underwent resting-state functional MRI (fMRI) before and after smoking a cigarette that delivered 0.027, 0.110, 0.231, or 0.763 mg of nicotine. Functional connectivity between the anterior insula and anterior cingulate cortex (ACC) and between the nucleus accumbens and orbitofrontal cortex (OFC) was assessed. Smoking reduced craving, negative affect, and nucleus accumbens-OFC connectivity irrespective of nicotine dose, with positive correlations of the effects on behavioral and connectivity measures. Only the highest nicotine dose (0.763 mg) reduced right anterior insula-ACC connectivity; this reduction was positively correlated with the behavioral effects of the 0.763-mg dose only. While nicotine-based therapies may act on right anterior insula-ACC functional circuits to facilitate smoking cessation, non-nicotine (eg, the conditioned and sensorimotor) aspects of smoking may promote cessation by reducing OFC-accumbens connectivity to alleviate withdrawal

Sam. von Butschky/ und Rutinfeld/ etc: Pathmos : enthaltend: Sonderbare Reden/ und Betrachtungen/ allerhand Curioser ... Wie auch bey ietziger Politic fürgehender/ Hoff- Welt- und Stats-Sachen ...

Vor dem Namen des Verf. Motto: A-ZAlternativer Fingerprint (bei eingeb. Beitr. von Hallmann): s,a- htn- o,nd bede 3 1677

Collegii Institut. Publici Disputatio Quarta. Ethico-Politico-Iuridica. De Tutela Eiusq[ue] Constitutione, Administratione & Dissolutione. Ad Tit. 14. 15. 16. 17. 18. 19. 20. 21. & 22. Exhibens Textus Continuationem, Quaestiones Antinomias & Axiomata

Quam Sub Praesidio Christiani Taubmani ... Discutiendam proponit Samuel Butschky Iun. Silesius. Ad diem 26. Septemb. In Auditorio ICtorum horis antemerid

Foreign Holdings of U.S. Agricultural Land Through December 31, 2022

Foreign persons held an interest in over 43.4 million acres of U.S. agricultural land as of December 31, 2022. This is 3.4 percent of all privately held agricultural land and nearly 2 percent of all land in the United States. These and other findings are based on an analysis of reports submitted in compliance with the Agricultural Foreign Investment Disclosure Act of 1978