60 research outputs found
SYNTHESIS OF (2-ARYLQUINAZOLIN-4-YL)HYDRAZONES OF 2-HYDROXYBENZALDEHYDES AS POTENTIAL PHOSPHOINOSITIDE 3-KINASE (IP3Kδ) AND CASEIN KINASE 2 (CK2) INHIBITORS
This work was supported by the Ministry of Science and Higher Education of Russian Federation, State Contract no FEUZ-2020-0058 (Н687.42Б.223/20)
Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes
2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4
Electronic structure investigation of CoO by means of soft X-ray scattering
The electronic structure of CoO is studied by resonant inelastic soft X-ray
scattering spectroscopy using photon energies across the Co 2p absorption
edges. The different spectral contributions from the energy-loss structures are
identified as Raman scattering due to d-d and charge-transfer excitations. For
excitation energies close to the L3 resonance, the spectral features are
dominated by quartet-quartet and quartet-doublet transitions of the 3d7
configuration. At excitation energies corresponding to the satellites in the Co
2p X-ray absorption spectrum of CoO, the emission features are instead
dominated by charge-transfer transitions to the 3d8L-1 final state. The spectra
are interpreted and discussed with the support of simulations within the single
impurity Anderson model with full multiplet effects which are found to yield
consistent spectral functions to the experimental data.Comment: 8 pages, 2 figures, 2 tables,
http://link.aps.org/doi/10.1103/PhysRevB.65.20510
Resonant soft X-ray Raman scattering of NiO
Resonant soft X-ray Raman scattering measurements on NiO have been made at
photon energies across the Ni 2p absorption edges. The details of the spectral
features are identified as Raman scattering due to d-d and charge-transfer
excitations. The spectra are interpreted within the single impurity Anderson
model, including multiplets, crystal-field and charge-transfer effects. At
threshold excitation, the spectral features consists of triplet-triplet and
triplet-singlet transitions of the 3d8 configuration. For excitation energies
corresponding to the charge-transfer region in the Ni 2p X-ray absorption
spectrum of NiO, the emission spectra are instead dominated by charge-transfer
transitions to the 3d9L-1 final state. Comparisons of the final states with
other spectroscopical techniques are also made.Comment: 9 pages, 2 figures, 2 tables,
http://iopscience.iop.org/0953-8984/14/13/32
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Studies of Actinides Reduction on Iron Surfaces by Means ofResonant Inelastic X-ray Scattering
The interaction of actinides with corroded iron surfaces was studied using resonant inelastic x-ray scattering (RIXS) spectroscopy at actinide 5d edges. RIXS profiles, corresponding to the f-f excitations are found to be very sensitive to the chemical states of actinides in different systems. Our results clearly indicate that U(VI) (as soluble uranyl ion) was reduced to U(IV) in the form of relatively insoluble uranium species, indicating that the iron presence significantly affects the mobility of actinides, creating reducing conditions. Also Np(V) and Pu (VI) in the ground water solution were getting reduced by the iron surface to Np(IV) and Pu (IV) respectively. Studying the reduction of actinides compounds will have an important process controlling the environmental behavior. Using RIXS we have shown that actinides, formed by radiolysis of water in the disposal canister, are likely to be reduced on the inset corrosion products and prevent release from the canister
Sliding charge density wave in manganites
The so-called stripe phase of the manganites is an important example of the
complex behaviour of metal oxides, and has long been interpreted as the
localisation of charge at atomic sites. Here, we demonstrate via resistance
measurements on La_{0.50}Ca_{0.50}MnO_3 that this state is in fact a
prototypical charge density wave (CDW) which undergoes collective transport.
Dramatic resistance hysteresis effects and broadband noise properties are
observed, both of which are typical of sliding CDW systems. Moreover, the high
levels of disorder typical of manganites result in behaviour similar to that of
well-known disordered CDW materials. Our discovery that the manganite
superstructure is a CDW shows that unusual transport and structural properties
do not require exotic physics, but can emerge when a well-understood phase (the
CDW) coexists with disorder.Comment: 13 pages; 4 figure
CK2 Inhibition and Antitumor Activity of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines
Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, the search and application of new low-toxic and effective drugs, combined with the timely diagnosis of diseases, makes it possible to cure most types of tumors at an early stage. In this work, the range of new polysubstituted 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines was extended. The structure of all the obtained compounds was confirmed by the data of 1H, 13C NMR spectroscopy, IR spectroscopy, and elemental analysis. These compounds were evaluated against human recombinant CK2 using the ADP-GloTM assay. In addition, the IC50 parameters were calculated based on the results of the MTT test against glioblastoma (A-172), embryonic rhabdomyosarcoma (Rd), osteosarcoma (Hos), and human embryonic kidney (Hek-293) cells. Compounds 5f, 5h, and 5k showed a CK2 inhibitory activity close to the reference molecule (staurosporine). The most potential compound in the MTT test was 5m with an IC50 from 13 to 27 µM. Thus, our results demonstrate that 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines are promising for further investigation of their antitumor properties. © 2022 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: FEUZ-2020–0058, H687.42B.223/20This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation, State Contract № FEUZ-2020–0058 (H687.42B.223/20)
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