Ossimoro e poesia: un percorso attraverso Montale, Caproni, Giudici e Zanzotto*

This paper aims to find a path of meaning which is divided into two contrapositive directions beginning from a semantic field (all/nothing) through the language of four main protagonists of Twentieth Century (Montale, Caproni, Giudici, Zanzotto), considering particularly the books published during the Sixties and the Seventies. Besides the cases of real and effective oxymoron, this study tries to identify the cases of nagated antithesis, almost eliminated by the collocation of the words inside the versal metrical plot that interferes with the semantic level and the rhetoric level of a text, dinamically.Questo lavoro mira a individuare attraverso la lingua di quattro nomi centrali della poesia del Novecento (Montale, Caproni, Giudici, Zanzotto), considerandone in particolare le raccolte degli anni Sessanta e Settanta, un percorso di significato che si articola in due direzioni contrapposte a partire dal campo semantico tutto/nulla. Accanto ai casi di ossimoro vero e proprio, vengono valutati i casi di antitesi negata, quasi annientata, nullificata anche grazie alla disposizione dei lessemi nell’orditura metrica dei versi che interagisce dinamicamente con il livello semantico e con il livello retorico del testo

Parenthetical clauses in Pavese´s prose

Incidentali nella prosa di PaveseL’intervento analizza tipi e occorrenze di incisi e proposizioni incidentali in quattro romanzi di Cesare Pavese: Paesi tuoi, Il compagno, Tra donne sole, La luna e i falò. Gli incisi (legati tanto all’oralità quanto alla tradizione letteraria) si prestano sia all’approfondimento soggettivo-lirico della psicologia dei personaggi, sia alla moltiplicazione dei piani e delle prospettive del racconto, sia alla stilizzazione sintattica, alla frammentazione (con introduttori grafici marcati) del tessuto della frase. Dall’esame dei tipi (incidentali primarie; incidentali introdotte da trattino all’inglese; incisi di parola e di sintagma; incisi didascalia; incidentali di secondo grado), si nota che in Pavese gli incisi diventano uno strumento sintattico maneggevole e polifunzionale, che scioglie l’autore dalle preoccupazioni di una resa naturalistica della realtà, e gli consente di attingere, soprattutto dopo Il compagno, al potenziale della narrazione autodiegetica, con una resa sintattica veloce, segmentata, ellittica ma non confusa, in quanto condotta e tessuta sulla trama di un’oralità stilizzata e sull’ordito di simmetrie e parallelismi di stampo classico.The essay analyzes types and occurrences of parentheses and parenthetical clauses in four novels by Cesare Pavese: Paesi tuoi, Il compagno, Tra donne sole, La luna e i falò. Parentheses – tied equally to orality and literary tradition – fit either for deeping character psychology in a subjective lyrical manner or multiplying narrative planes and perspectives or even gaining syntactic stylization and phrasal texture fragmentation by the use of marked graphic introducers. By the examination of the types (primary parentheticals; parentheticals introducted by a dash; word and syntagm parentheses; didascalic parentheses; secondary parentheticals), it may be noted that parentheses in Pavese become an easy-to-handle and multipurpose syntactic tool, that frees the author’s mind from the worries of a naturalistic restitution of reality, and allows him – particularly after Il compagno – to reach the potential of autodiegetic narration, through a syntactic restitution that is fast, segmented, elliptical, yet not confusing, for it is unfolded and woven on the warp of a stylized orality and the weft of symmetries and parallelisms of firm classic mould

Ossimoro e poesia: un percorso attraverso Montale, Caproni, Giudici e Zanzotto*

This paper aims to find a path of meaning which is divided into two contrapositive directions beginning from a semantic field (all/nothing) through the language of four main protagonists of Twentieth Century (Montale, Caproni, Giudici, Zanzotto), considering particularly the books published during the Sixties and the Seventies. Besides the cases of real and effective oxymoron, this study tries to identify the cases of nagated antithesis, almost eliminated by the collocation of the words inside the versal metrical plot that interferes with the semantic level and the rhetoric level of a text, dinamically

Incidentali nella prosa di Pavese

Incidentali nella prosa di Pavese</p

The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination

Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol biosynthesis, oxidosqualene cyclase (OSC), in regulating tumour angiogenesis and metastasis dissemination in mouse models of cancer. We showed that Ro 48-8071, a selective inhibitor of OSC, reduced vascular density and increased pericyte coverage, with a consequent inhibition of tumour growth in a spontaneous mouse model of pancreatic tumour (RIP-Tag2) and two metastatic mouse models of human colon carcinoma (HCT116) and pancreatic adenocarcinoma (HPAF-II). Remarkably, the inhibition of OSC hampered metastasis formation in HCT116 and HPAF-II models. Ro 48-8071 induced tumour vessel normalization and enhanced the anti-tumoral and anti-metastatic effects of 5-fluorouracil (5-FU) in HCT116 mice. Ro 48-8071 exerted a strong anti-angiogenic activity by impairing endothelial cell adhesion and migration, and by blocking vessel formation in angiogenesis assays. OSC inhibition specifically interfered with the PI3K pathway. According to in vitro results, Ro 48-8071 specifically inhibited Akt phosphorylation in both cancer cells and tumour vasculature in all treated models. Thus, our results unveil a crucial role of OSC in the regulation of cancer progression and tumour angiogenesis, and indicate Ro 48-8071 as a potential novel anti-angiogenic and anti-metastatic drug

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 α (PI4KIIα) toward the PM of CD4+ T cells. Hence, Rab27a promotes high levels of PM phosphatidylinositol 4-phosphate and the localized production of PI(4,5)P2, therefore controlling Pr55Gag membrane association. Rab27a also controls PI(4,5)P2 levels at the virus-containing compartments of macrophages. By screening Rab27a effectors, we identified that Slp2a, Slp3, and Slac2b are required for the association of Pr55Gag with the PM and that Slp2a cooperates with Rab27a in the recruitment of PI4KIIα to the PM. We conclude that by directing the trafficking of PI4KIIα-positive endosomes toward the PM, Rab27a controls PI(4,5)P2 production and, consequently, HIV-1 replication.Fil: Pereyra Gerber, Federico Pehuén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Cabrini, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Paoletti, Luciana Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Banchio, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Von Bilderling, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Sigaut, Lorena. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pietrasanta, Lia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Freed, Eric O.. National Cancer Institute at Frederick; Estados UnidosFil: Basile, Genevieve de Saint. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Moita, Catarina Ferreira. Instituto Gulbenkian de Ciencia; PortugalFil: Moita, Luis Ferreira. Instituto Gulbenkian de Ciencia; PortugalFil: Amigorena, Sebastian. Institute Curie; FranciaFil: Benaroch, Philippe. Institute Curie; FranciaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOSI Register

Beta (β)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to β2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective β1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with HF and COPD than in patients affected by HF alone, both at admission and at discharge (admission, 36.9% vs. 51.3%; discharge, 38.0% vs. 51.7%). In addition, no further BB users were found at discharge. The probability to being treated with a BB was significantly lower in patients with HF also affected by COPD (adj. OR, 95% CI: 0.50, 0.37-0.67), while the diagnosis of COPD was not associated with the choice of selective β1-BB (adj. OR, 95% CI: 1.33, 0.76-2.34). Despite clear recommendations by clinical guidelines, a significant underuse of BBs was also observed after hospital discharge. In COPD affected patients, physicians unreasonably reject BBs use, rather than choosing a β1-BB. The expected improvement of the BB prescriptions after hospitalization was not observed. A multidisciplinary approach among hospital physicians, general practitioners, and pharmacologists should be carried out for better drug management and adherence to guideline recommendations