Magnetic fields

Effects of high and low gradient magnetic fields on human performance for space flight application

Interrupting the social amplification of risk process: a case study in collective emissions reduction

One of the main approaches we have for studying the progressive divergence of understandings around a risk issue is that of social risk amplification. This article describes a case study of a particular environmental contaminant, a chemical flame retardant that could be interpreted as having produced a risk amplifying process. It describes in particular how a group of industrial organizations acted collectively to reduce emissions of this contaminant, in an apparent attempt to avert regulation and boycotts—that is, to intercept the social amplification process and avoid its secondary effects. The aim of the study was to investigate the constitutive qualities of this collective action: the qualities that defined it and made it effective in the eyes of those involved. These include institutionalisation and independence, the ability to confer individual as well as collective benefit, the capacity to attract (rather than avoid) criticism, and the ‘branding’ that helps communicate what otherwise appear to be a set of unconnected, local actions. Although the risk amplification framework has been criticised for implying that there is some externally given risk level that is subsequently amplified, it does appear to capture the mentality of actors involved in issues of this kind. They talk and act as though they believe they are participants in a risk amplification process

Confined compression of collagen hydrogels

Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically > 99.5%). In the present study the mechanical behaviour of collagen hydrogels in confined compression was investigated using biphasic theory (J. Biomech. Eng. 102 (1980) 73), to ascertain whether the technique is sufficiently sensitive to determine differences in the characteristics of hydrogels of between 0.2% and 0.4% collagen. Peak stress, equilibrium stress, aggregate modulus and hydraulic permeability of the hydrogels exhibited sensitivity to collagen content, demonstrating that the technique is clearly able to discriminate between hydrogels with small differences in collagen content and may also be sensitive to factors that affect matrix remodelling. The results also offer additional insight into the deformation-dependent permeability of collagen hydrogels. This study suggests that confined compression, together with biphasic theory, is a suitable technique for assessing the mechanical properties of collagen hydrogels

Ultrasound Guided Placement of Single-Lumen Peripheral Intravenous Catheters in the Internal Jugular Vein

Introduction: The peripheral internal jugular (IJ), also called the “easy IJ,” is an alternative to peripheral venous access reserved for patients with difficult intravenous (IV) access. The procedure involves placing a single-lumen catheter in the IJ vein under ultrasound (US) guidance. As this technique is relatively new, the details regarding the ease of the procedure, how exactly it should be performed, and the safety of the procedure are uncertain. Our primary objective was to determine the success rate for peripheral IJ placement. Secondarily, we evaluated the time needed to complete the procedure and assessed for complications. Methods: This was a prospective, single-center study of US-guided peripheral IJ placement using a 2.5-inch, 18-gauge catheter on a convenience sample of patients with at least two unsuccessful attempts at peripheral IV placement by nursing staff. Peripheral IJ lines were placed by emergency medicine (EM) attending physicians and EM residents who had completed at least five IJ central lines. All physicians who placed lines for the study watched a 15-minute lecture about peripheral IJ technique. A research assistant monitored each line to assess for complications until the patient was discharged. Results: We successfully placed a peripheral IJ in 34 of 35 enrolled patients (97.1%). The median number of attempts required for successful cannulation was one (interquartile range (IQR): 1 to 2). The median time to successful line placement was 3 minutes and 6 seconds (IQR: 59 seconds to 4 minutes and 14 seconds). Two lines failed after placement, and one of the 34 successfully placed peripheral IJ lines (2.9%) had a complication – a local hematoma. There were, however, no arterial punctures or pneumothoraces. Although only eight of 34 lines were placed using sterile attire, there were no line infections. Conclusion: Our research adds to the growing body of evidence supporting US-guided peripheral internal jugular access as a safe and convenient procedure alternative for patients who have difficult IV access

Targets for the MalI repressor at the divergent Escherichia coliK-12malX-malI promoters

Random mutagenesis has been used to identify the target DNA sites for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. The malX promoter is repressed by MalI binding to a DNA site located from position -24 to position -9, upstream of the malX promoter transcript start. The malI promoter is repressed by MalI binding from position +3 to position +18, downstream of the malI transcript start. MalI binding at the malI promoter target is not required for repression of the malX promoter. Similarly, MalI binding at the malX promoter target is not required for repression of the malI. Although the malX and malI promoters are regulated by a single DNA site for cyclic AMP receptor protein, they function independently and each is repressed by MalI binding to a different independent operator site

Madrid: Literary Fiction and the Imaginary Urban Destination

This study selects novels from French and Spanish language traditions, which may not be available to English-speakers, in order to determine if specific aspects throw light on our understanding of Madrid as a destination. Marc Lambron's L'Impromptu de Madrid and Antonio Munoz Molina’s Mysteries of Madrid are taken as proof of the influence the narrative can exert on social daily life and consumption. Narrative foregrounds the fictions which are at stake in imagining the city as destination and also provides a vehicle for presenting the much broader social forces that converge in the author at the time of imagining and writing

Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis

Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treated patients (Standardised Mean Difference (SMD) −0.37, 95% confidence interval (CI) −0.55 to −0.20; p < 0.0001), with no difference in mean scores between patients and healthy controls after one year (SMD 0.01, 95% CI −0.18 to 0.20, p = 0.94). There was a tendency towards worsening symptoms for non-coeliac gluten sensitive patients during a blinded gluten challenge vs. placebo (SMD 0.21, 95% CI −0.58 to 0.15; p = 0.25). Our review supports the association between mood disorders and gluten intake in susceptible individuals. The effects of a GFD on mood in subjects without gluten-related disorders should be considered in future research

Factors Affecting Lot Low Choice and Above and Lot Premium Choice Acceptance Rate of Beef Calves in the Tri-County Steer Carcass Futurity Program

Data describing 220 lots of beef cattle in the Tri-County Steer Carcass Futurity program from 2003 through 2007 were analyzed using a multiple regression statistical model to determine specific factors that influence lot low Choice and above rate and lot premium Choice (Certified Angus Beef © ) acceptance rate. Lot low Choice and above rate was similar for years 2005-2007. This rate was significantly lower in 2003 than 2004 but both the 2003 and 2004 rates were similar to the rate in all other years. Lots consisting of heifers had higher (P\u3c.05) low Choice and above rates than lots of steers or mixed-sex pens. The greater the amount of Angus influence in the cattle, the higher the low Choice and above rate (P\u3c.0001). An inverse relationship existed between feedlot in-weight and lot low Choice and above rate; those cattle with lighter feedlot arrival weights had higher % Choice and above rates (P=.0007). Cattle with lower disposition scores (calmer cattle) had higher % Choice and above rates (P=.0496). Low Choice and above rate increased as cattle became less efficient in converting feed to gain (P=.0027). An inverse relationship existed between cost of gain and low Choice and above rate; those cattle with lower cost of gain had higher low Choice and above rates (P=.0043). Lot low Choice and above rate increased as average daily gain increased (P=.0094). Factors examined that did not have a significant effect on lot low Choice and above rate were: mud score at final sort, geographic region of origin, lot mortality rate, number of harvest groups within each lot, days on feed, adjusted final weight, individual treatment cost per head, lot size, and season of harvest. Lot premium Choice acceptance rate was similar in each year from 2003-2006 but was significantly lower in 2007 compared with all other years. Lots consisting of heifers had higher (P\u3c.05) premium Choice acceptance rates than lots of steers or mixed-sex pens. Cattle harvested during the months October through December had a lower lot premium Choice acceptance rate than those harvested during January through March, April through June, or July through September (P\u3c.05). The greater the amount of Angus influence in the cattle, the higher the lot premium Choice acceptance rate (P\u3c.0064). An inverse relationship existed between feedlot in-weight and lot premium Choice acceptance rate; those cattle with lighter feedlot arrival weights had higher premium Choice acceptance rates (P\u3c.0001). Lot premium Choice acceptance rate increased as average daily gain increased (P=.0003); however lots of cattle that were less efficient at converting feed into gain had higher premium Choice acceptance rates (P\u3c.0104). Factors examined that did not have a significant effect on lot premium Choice acceptance rate were: mud score at final sort, individual treatment cost per head, number of harvest groups within each lot, days on feed, cost of gain, lot size, geographic region of origin, average disposition score, adjusted final weight, and lot mortality rate