78 research outputs found
The measurement of sport culture identity development level
Management of studentsβ sport culture identity development in the process of sport oriented physical education should be based on provided information about the dynamics of its development objectively and quantitatively. The article presents the criteria and indicators of sport culture identity development and adequate techniques for their measurementΠ£ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΏΠΎΡΡΠΈΠ²Π½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ Π»ΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΏΠΎΡΡΠΈΠ²Π½ΠΎ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠΈΡΠ°Π½ΠΈΡ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡΡΡ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΠΌΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΏΠΎΡΡΠΈΠ²Π½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ Π»ΠΈΡΠ½ΠΎΡΡΠΈ ΠΈ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΠ΅ ΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΈΡ
ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈ
Features of statistical methods application in rating construction
The article is devoted to solving the problem of rating construction methodology, including issues of comparability in dynamics and inconsistency. The study analyzes approaches to the procedures for aggregating private components of the rating. Attention is focused on the shortcomings of ratings used in international and domestic practice as integral meters, among which are the incompleteness of information on the private components of ratings, an unacceptably high level of error in the development of ratings as integral meters and the lack of evaluation of their quality. The approach to rating construction on the basis of average weighted sum of ranks is offered. The ratio of the sum of the squares of the rank paired coefficients of the private rating to the total sum of the squares of the rank coefficients for all private ratings (the matrix of squares of rank correlations) is used as weights. The approach proposed by the authors, in contrast to the existing methodological approaches, makes it possible to build a rating in the absence of information about private components. The novelty of the study results lies in the method of estimating weights of private ratings as basic components of the rating. The article presents the results of construction a rating of the regions of the Central Federal District in Russia for achieving national goals in 2021 based on private ratings, which confirmed the adequacy of the proposed approach. The article may be of interest to a wide range of researchers in the field of statistics and regional economics
Tourism as a Factor of Increased Competitiveness of the Region
The paper considers tourism and tourism operations as one of the key priorities of increased competitive strengths of Russian regions, their area, socio- economic status and image. One of the presented ways of sustainable and effective development of tourism industry of the region is the formation of large-scale interregional, international associations conducting their activities for increased main competitive indicators and living conditions. Thus, the main function of performers of tourism operations of the considered territory will be to control work of regional agencies of local government that promotes increased quality of tourist management and defines the key possible priorities of development of the issues to solve being as follows: -development of a procedure of sharing experiences between regions; -attraction of an investor and additional financial means in the course of development of travel industry; -Β creation and promotion of positive image of the district, region and tourist base; - development of interregional projects which are in physical proximity of territories that promotes increase number of tourist routes and increases the potential of regions.
Keywords: region, competitiveness, tourism, interregional ties, innovations, state
JEL Classifications: F43, L83, O4
Changes in the reactivity of the vertebrobasilar arteries when using glucose-electrolyte drink with antioxidant plant extracts during submaximal exercise test
The aim. To assess the effect of glucose-electrolyte composition with plant extracts having antioxidant activity on the hemodynamic parameters of vertebrobasilar system during the incrementally increasing submaximal exercise test.Materials and methods. The study included 12Β athletes (6 candidates for master ofΒ sports and 6Β masters of sports) aged 18β22, who have been engaged in orienteering for 10Β years and more. Time of aerobic exercise β 2Β hours a day, five days a week. The study subjects performed anΒ incrementally increasing submaximal exercise test and also submaximal exercise test with the preventive intake of a glucose-electrolyte composition with plant extracts having antioxidant properties. To assess the hemodynamic parameters in all study subjects we used Doppler ultrasound ofΒ the cerebral vessels, evaluating vertebrobasilar system blood flow, exercise gas test in the modification of hypo- and hyperventilation, and also positional test.Results. A single intake of glucose-electrolyte drink under conditions of incrementally increasing exercise test contributed to the manifestation of a homeostatic effect in hemodynamic parameters of the vertebrobasilar arteries. It is evidenced byΒ theΒ approximation to the pre-exercise level ofΒ maximum systolic velocity andΒ average blood velocity in the breath-holding test, of the diastolic blood velocity inΒ theΒ hyperventilation test, and of the pulsatility index in the torsion test, as compared toΒ theΒ isolated submaximal exercise test which caused the change in both velocity indicators andΒ calculated indices during the functional tests.The article considers the main mechanisms underlying the change in arterial hemodynamic parameters caused by incrementally increasing load, as well as describes the proposed mechanisms arising from the combined effect of an incrementally increasing load and the intake of a glucose-electrolyte composition with plant extracts having antioxidant activity.Conclusion. It was shown that using glucose-electrolyte drink contributed to the restoration of hemodynamic parameters of the vertebrobasilar arteries after an incrementally increasing submaximal exercise test
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Spent fuel sabotage aerosol test program :FY 2005-06 testing and aerosol data summary.
This multinational, multi-phase spent fuel sabotage test program is quantifying the aerosol particles produced when the products of a high energy density device (HEDD) interact with and explosively particulate test rodlets that contain pellets of either surrogate materials or actual spent fuel. This program has been underway for several years. This program provides source-term data that are relevant to some sabotage scenarios in relation to spent fuel transport and storage casks, and associated risk assessments. This document focuses on an updated description of the test program and test components for all work and plans made, or revised, primarily during FY 2005 and about the first two-thirds of FY 2006. It also serves as a program status report as of the end of May 2006. We provide details on the significant findings on aerosol results and observations from the recently completed Phase 2 surrogate material tests using cerium oxide ceramic pellets in test rodlets plus non-radioactive fission product dopants. Results include: respirable fractions produced; amounts, nuclide content, and produced particle size distributions and morphology; status on determination of the spent fuel ratio, SFR (the ratio of respirable particles from real spent fuel/respirables from surrogate spent fuel, measured under closely matched test conditions, in a contained test chamber); and, measurements of enhanced volatile fission product species sorption onto respirable particles. We discuss progress and results for the first three, recently performed Phase 3 tests using depleted uranium oxide, DUO{sub 2}, test rodlets. We will also review the status of preparations and the final Phase 4 tests in this program, using short rodlets containing actual spent fuel from U.S. PWR reactors, with both high- and lower-burnup fuel. These data plus testing results and design are tailored to support and guide, follow-on computer modeling of aerosol dispersal hazards and radiological consequence assessments. This spent fuel sabotage--aerosol test program, performed primarily at Sandia National Laboratories, with support provided by both the U.S. Department of Energy and the Nuclear Regulatory Commission, had significant inputs from, and is strongly supported and coordinated by both the U.S. and international program participants in Germany, France, and the U.K., as part of the international Working Group for Sabotage Concerns of Transport and Storage Casks, WGSTSC
Abel Symposia
Discrete Morse theory has recently lead to new developments in the theory of random geometric complexes. This article surveys the methods and results obtained with this new approach, and discusses some of its shortcomings. It uses simulations to illustrate the results and to form conjectures, getting numerical estimates for combinatorial, topological, and geometric properties of weighted and unweighted Delaunay mosaics, their dual Voronoi tessellations, and the Alpha and Wrap complexes contained in the mosaics
Quantification of C1 esterase inhibitor in human serum by enzyme-linked immunosorbent assay: Correlation with turbidimetric immunoassay
C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency of C1-INH leads to various forms of angioedema, including hereditary angioedema (HAE). The cause of HAE is a genetically determined violation of the synthesis of C1-INH. A decrease in the level of C1-INH to 50% relative to the norm leads to an increase in the production of bradykinin, which is the basis for the diagnosis of HAE. The development of affordable ELISA for the quantitative determination of C1-INH is a popular direction for clinicians. During the development of a new kit for quantitative determination of C1-INH, two mouse monoclonal antibodies (mAb) with different epitope specificities were obtained. On their basis, a sandwich-type ELISA was developed. The specificity of the obtained mAb's was confirmed using the medical device βBerinertβ. To prepare calibrators, C1-INH was affinity purified from human blood plasma using a sorbent with immobilized mAbs. The identity of the C1-INH protein was confirmed by PAGE electrophoresis, immunoblotting, and mass spectrometry on MALDI-TOF/TOF UltrafleXtreme mass spectrometer. To assess the quality indicators of developed reagents kit, studies were carried out in accordance with GOST R 51352-2013 and TU 21.20.23-041-01967164-2022. Values of quality indicators: accuracy β 93.53%; measurement linearity interval β 22.00-176.07 ng/mL. Using the developed ELISA test system, we examined 28 blood sera from healthy donors and 7 blood sera from patients with confirmed HAE. In the same samples, the content of C1-INH was determined by turbidimetric method, using the "Diagnostic reagents for in vitro immunochemical studies of specific blood proteins. Model: C1-esterase inhibitor (C1 EsteraseInhibitor)" (Aptec, Belgium). The correlation coefficient was 0.94 (p < 0.05). It was found that the diagnostic sensitivity and specificity of the developed ELISA is 100%. As a result of the study, an original ELISA test system for the quantitative determination of C1-INH was developed "Reagent kit for enzyme-linked immunosorbent assay of human C1-inhibitor (C1-inh PS)"
ΠΠ°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΡ Π³ΡΠΈΠΏΠΏΠΎΠΌ Π² ΡΠ½Π²Π°ΡΠ΅-ΠΌΠ°ΡΡΠ΅ 2016 Π³. Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ: ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° A(H1N1)pdm09
The World Health Organization (WHO) searches influenza virus circulation in community and in natural biocenosis, studies virus strains and their properties, develops diagnostic methods and preventive measures since 1940th worldwide because of epidemic actuality and high pandemic potential of the influenza virus. The Federal Influenza Center (including Federal Research Institute of Influenza, Saint-Petersburg, and the Center of Virus Ecology, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Moscow) performs similar work in Russia in close cooperation with WHO within the framework of the International Programme of Influenza Monitoring. A(H1N1)pdm09 influenza virus dominated in the Northern Hemisphere in the 2015 β 2016 epidemic season. Morbidity growth was noted from the end of January, 2016, to the beginning of March, 2016. The peak morbidity at the 5th week of the year exceeded the epidemic threshold (132 cases per 10,000 of population) and morbidity in the 2014 β 2015 season significantly and approached to the peak morbidity of the 2009 β 2010 epidemic season. The epidemic growth in Russian Federation was provided by three influenza viruses: A(H1N1)pdm09, Π and A (H3N2). A(H1N1)pdm09 virus caused 18% of all acute respiratory diseases and accounted for 84% of circulating influenza viruses.Flu was diagnosed in patients of different age with maximal frequency in 3- to 6-year old children. Peak admission number was registered at 5 and 6 weeks (3,538 and 4,109 cases, respectively); this number exceeded the similar parameter of the 2009 β 2010 season. Patients of 15 to 64 years old were admitted more often including those with acute respiratory infection. Two hundred and thirty nine deaths were registered to the 5th of April, 2016, according to data from the Federal Influenza Center and the Center of Virus Ecology. The diagnosis of A(H1N1)pdm09 flu was confirmed in 97.9% of deaths. Molecular analysis of isolated strains of A(H1N1)pdm09 influenza virus revealed amino acid substitutions in receptor binding site and SA site of hemagglutinin and in genes coding intrinsic proteins PA, NP, M1, and NS1. Influenza virus strains resistive to anti-neuraminidase drugs were encountered in #< 1% in the Northern Hemisphere countries. No strains studied were sensitive to adamantine derivates.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π‘ 1947 Π³. Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡΡ ΠΈ Π²ΡΡΠΎΠΊΠΈΠΌ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° ΡΠΈΠΏΠ° Π ΠΏΠΎ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠ²Π΅ ΠΡΠ΅ΠΌΠΈΡΠ½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ (ΠΠΠ) ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π° ΠΠ»ΠΎΠ±Π°Π»ΡΠ½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΏΠΎ Π½Π°Π΄Π·ΠΎΡΡ Π·Π° Π³ΡΠΈΠΏΠΏΠΎΠΌ ΠΈ ΠΎΡΠ²Π΅ΡΡ (Global Influenza Surveillance and Response System β GISRS), ΠΊΠΎΡΠΎΡΠ°Ρ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° 6 ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ°ΡΡΠΈΠΌΠΈ ΡΠ΅Π½ΡΡΠ°ΠΌΠΈ ΠΏΠΎ Π³ΡΠΈΠΏΠΏΡ, 143 Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ ΡΠ΅Π½ΡΡΠ°ΠΌΠΈ ΠΏΠΎ Π³ΡΠΈΠΏΠΏΡ Π² 113 ΡΡΡΠ°Π½Π°Ρ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ Π³ΡΠΈΠΏΠΏΠΎΠ·Π½ΡΡ
Π²Π°ΠΊΡΠΈΠ½. Π ΠΎΡΡΠΈΠΉΡΠΊΠ°Ρ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° Π² ΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ Π΄Π²ΡΠΌΡ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ ΡΠ΅Π½ΡΡΠ°ΠΌΠΈ β Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ΅Π½ΡΡΠΎΠΌ ΠΏΠΎ Π³ΡΠΈΠΏΠΏΡ (Π€Π¦Π) Π€ΠΠΠ£ Β«ΠΠ°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠΈΡΡΡ Π³ΡΠΈΠΏΠΏΠ°Β» ΠΠΈΠ½Π·Π΄ΡΠ°Π²Π° Π ΠΎΡΡΠΈΠΈ (Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³) ΠΈ Π¦Π΅Π½ΡΡΠΎΠΌ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π³ΡΠΈΠΏΠΏΠ° (Π¦ΠΠΠ) ΠΠ½ΡΡΠΈΡΡΡΠ° Π²ΠΈΡΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΌ. Π.Π.ΠΠ²Π°Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ Π€ΠΠΠ£ Β«Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΡΠΉ Π½Π°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ ΡΠ΅Π½ΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΌΠ΅Π½ΠΈ ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΊΠ° Π.Π€.ΠΠ°ΠΌΠ°Π»Π΅ΠΈΒ» ΠΠΈΠ½Π·Π΄ΡΠ°Π²Π° Π ΠΎΡΡΠΈΠΈ (ΠΠΎΡΠΊΠ²Π°). ΠΠ±Π° ΡΠ΅Π½ΡΡΠ° ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡ Π΅ΠΆΠ΅Π½Π΅Π΄Π΅Π»ΡΠ½ΡΠΉ Π½Π°Π΄Π·ΠΎΡ Π·Π° ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠ΅ΠΉ Π²ΠΈΡΡΡΠΎΠ² Π³ΡΠΈΠΏΠΏΠ° Π² 59 Π³ΠΎΡΠΎΠ΄Π°Ρ
Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅Ρ Π°Π½Π°Π»ΠΈΠ· Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ, Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π»Π΅ΡΠ°Π»ΡΠ½ΡΡ
ΡΠ»ΡΡΠ°Π΅Π² ΠΎΡ Π³ΡΠΈΠΏΠΏΠ° ΠΈ ΠΎΡΡΡΠΎΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ (ΠΠ ΠΠ) Π² ΡΠ°Π·Π½ΡΡ
Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ². ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΡΡΡΠ°Π½Π°Ρ
Π‘Π΅Π²Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΡ Π² ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅Π·ΠΎΠ½Π΅ 2015β2016 Π³Π³. Π² ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎΠ΄ΡΠ΅ΠΌΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π» Π²ΠΈΡΡΡ Π³ΡΠΈΠΏΠΏΠ° A(H1N1)pdm09. ΠΠΎΠ΄ΡΠ΅ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π³ΡΠΈΠΏΠΏΠΎΠΌ Π² Π ΠΎΡΡΠΈΠΈ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ Ρ ΠΊΠΎΠ½ΡΠ° ΡΠ½Π²Π°ΡΡ Π΄ΠΎ Π½Π°ΡΠ°Π»Π° ΠΌΠ°ΡΡΠ° 2016 Π³. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π½Π° ΠΏΠΈΠΊΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ (5-Ρ Π½Π΅Π΄Π΅Π»Ρ 2016 Π³.), Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠ΅Π²ΡΡΠΈΠ² ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠΎΠ³ (132 ΡΠ»ΡΡΠ°Ρ Π½Π° 10 ΡΡΡ. Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ) ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π·ΠΎΠ½Π° 2014β2015 Π³Π³., ΠΎΡΠΌΠ΅ΡΠ΅Π½ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π·ΠΎΠ½Π° 2009β2010 Π³Π³. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΡΠΊΡΡΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄ΡΠ΅ΠΌΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π² Π Π€ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ 3 Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° β A(H1N1)pdm09, Π ΠΈ A(H3N2) ΠΏΡΠΈ ΡΠ°Π·Π½ΠΎΠΌ Π΄ΠΎΠ»Π΅Π²ΠΎΠΌ ΡΡΠ°ΡΡΠΈΠΈ. ΠΡΠΈΠΏΠΏ A(H1N1)pdm09 Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΠ ΠΠ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 18,0 %, Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΡ
Π²ΠΈΡΡΡΠΎΠ² Π³ΡΠΈΠΏΠΏΠ° β 84,0 %. ΠΠ°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΡ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π²ΠΎ Π²ΡΠ΅Ρ
Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. Πα½ΉΠ»ΡΡΠ°Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½Π½ΠΎΡΡΡ Π² ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π° Ρ Π΄Π΅ΡΠ΅ΠΉ 3β6 Π»Π΅Ρ. ΠΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠΈΡΠ»ΠΎ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΉ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π½Π° 5-ΠΉ ΠΈ 6-ΠΉ Π½Π΅Π΄Π΅Π»ΡΡ
2016 Π³. β 3Β 538 ΠΈ 4Β 109 ΡΠ»ΡΡΠ°Π΅Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, ΡΡΠΎ ΠΏΡΠ΅Π²ΡΡΠΈΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ΅Π·ΠΎΠ½Π° 2009β2010 Π³Π³. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ ΡΠΈΡΠ»ΠΎ ΡΠ»ΡΡΠ°Π΅Π² Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π² Ρ. Ρ. Ρ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΎΡΡΡΠΎΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ, ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ 15β64 Π»Π΅Ρ. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ Π€Π¦Π ΠΈ Π¦ΠΠΠ, Π½Π° 05.04.16 Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ 239 Π»Π΅ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ². Π 97,9 % ΡΠ»ΡΡΠ°Π΅Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ Π³ΡΠΈΠΏΠΏ A(H1N1)pdm09. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ² Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° A / H1N1pdm09 ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΠ½ΡΡ
Π·Π°ΠΌΠ΅Π½ Π² Π³Π΅ΠΌΠ°Π³Π³Π»ΡΡΠΈΠ½ΠΈΠ½Π΅ (ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅ΠΌ ΠΈ Sa ΡΠ°ΠΉΡΠ°Ρ
) ΠΈ Π² Π³Π΅Π½Π°Ρ
, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΡ
Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΈ (PA, NP, M1, NS1). ΠΠΎΠ»Ρ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΊ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ Ρ Π°Π½ΡΠΈΠ½Π΅ΠΉΡΠ°ΠΌΠΈΠ½ΠΈΠ΄Π°Π·Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Π² ΡΡΡΠ°Π½Π°Ρ
Π‘Π΅Π²Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΡ Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠΈΠ»Π° 1 %, Π° ΠΊ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠΌ Π°Π΄Π°ΠΌΠ°Π½ΡΠ°Π½Π° ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π½Π΅ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π²ΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ ΡΡΠ°ΠΌΠΌΡ
Peculiarities of the influenza viruses circulation and their properties during 2018-2019 epidemic season in Russia and countries of the Northern Hemisphere
Objective. To identify the drift variability of influenza viruses during the period of epidemic rise in the incidence of acute respiratory viral infections in the period 2018-2019. The biological and molecular-genetic properties of epidemic strains isolated in certain territories of the Russian Federation were studied and compared with data from the countries of the Northern Hemisphere. Materials and methods. A range of laboratory diagnostic methods has been applied, including immune fluorescence, RT-PCR, sequencing, methods for determining sensitivity to influenza drugs and receptor specificity. Results and discussion. The proportion of influenza viruses was as follows: A (H1N1) pdm09 - 53 %, A (H3N2) - 46 %, B - about 1 %. Cases of severe acute respiratory infections have most often been associated with influenza A(H1N1) pdm09 virus. According to antigenic properties, isolated strains corresponded to the properties of vaccine viruses (A/Michigan/45/2015 - by 99.6 % and A/Singapore INFIMH-16-0019/2016 - by 86 %). The heterogeneity of influenza A virus strains population was revealed as regards individual mutations in hemaglutinin. The influenza B virus population was equally represented by both evolutionary lines (B/Victoria and B/Yamagata-like). Receptor specificity was favorable for the course and outcome of the disease. Among 70 studied epidemic strains, no strains resistant to anti-neuraminidase drugs, oseltamivir and zanamivir, were detected. The article presents WHO recommendations on the composition of influenza vaccines for the countries of the Northern Hemisphere for 2019-2020, provides data on cases of human infection with avian influenza viruses A(H5N1), A(H5N6), A(H7N9) and A(H9N2)
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