118 research outputs found
Earthshine observation of vegetation and implication for life detection on other planets - A review of 2001 - 2006 works
The detection of exolife is one of the goals of very ambitious future space
missions that aim to take direct images of Earth-like planets. While
associations of simple molecules present in the planet's atmosphere (,
, etc.) have been identified as possible global biomarkers, we
review here the detectability of a signature of life from the planet's surface,
i.e. the green vegetation. The vegetation reflectance has indeed a specific
spectrum, with a sharp edge around 700 nm, known as the "Vegetation Red Edge"
(VRE). Moreover vegetation covers a large surface of emerged lands, from
tropical evergreen forest to shrub tundra. Thus considering it as a potential
global biomarker is relevant. Earthshine allows to observe the Earth as a
distant planet, i.e. without spatial resolution. Since 2001, Earthshine
observations have been used by several authors to test and quantify the
detectability of the VRE in the Earth spectrum. The egetation spectral
signature is detected as a small 'positive shift' of a few percents above the
continuum, starting at 700 nm. This signature appears in most spectra, and its
strength is correlated with the Earth's phase (visible land versus visible
ocean). The observations show that detecting the VRE on Earth requires a
photometric relative accuracy of 1% or better. Detecting something equivalent
on an Earth-like planet will therefore remain challenging, moreover considering
the possibility of mineral artifacts and the question of 'red edge'
universality in the Universe.Comment: Invited talk in "Strategies for Life Detection" (ISSI Bern, 24-28
April 2006) to appear in a hardcopy volume of the ISSI Space Science Series,
Eds, J. Bada et al., and also in an issue of Space Science Reviews. 13 pages,
8 figures, 1 tabl
Neutron star properties in the quark-meson coupling model
The effects of internal quark structure of baryons on the composition and
structure of neutron star matter with hyperons are investigated in the
quark-meson coupling (QMC) model. The QMC model is based on mean-field
description of nonoverlapping spherical bags bound by self-consistent exchange
of scalar and vector mesons. The predictions of this model are compared with
quantum hadrodynamic (QHD) model calibrated to reproduce identical nuclear
matter saturation properties. By employing a density dependent bag constant
through direct coupling to the scalar field, the QMC model is found to exhibit
identical properties as QHD near saturation density. Furthermore, this modified
QMC model provides well-behaved and continuous solutions at high densities
relevant to the core of neutron stars. Two additional strange mesons are
introduced which couple only to the strange quark in the QMC model and to the
hyperons in the QHD model. The constitution and structure of stars with
hyperons in the QMC and QHD models reveal interesting differences. This
suggests the importance of quark structure effects in the baryons at high
densities.Comment: 28 pages, 10 figures, to appear in Physical Review
Lichenometric dating (lichenometry) and the biology of the lichen genus rhizocarpon:challenges and future directions
Lichenometric dating (lichenometry) involves the use of lichen measurements to estimate the age of exposure of various substrata. Because of low radial growth rates and considerable longevity, species of the crustose lichen genus Rhizocarpon have been the most useful in lichenometry. The primary assumption of lichenometry is that colonization, growth and mortality of Rhizocarpon are similar on surfaces of known and unknown age so that the largest thalli present on the respective faces are of comparable age. This review describes the current state of knowledge regarding the biology of Rhizocarpon and considers two main questions: (1) to what extent does existing knowledge support this assumption; and (2) what further biological observations would be useful both to test its validity and to improve the accuracy of lichenometric dates? A review of the Rhizocarpon literature identified gaps in knowledge regarding early development, the growth rate/size curve, mortality, regeneration, competitive effects, colonization, and succession on rock surfaces. The data suggest that these processes may not be comparable on different rock surfaces, especially in regions where growth rates and thallus turnover are high. In addition, several variables could differ between rock surfaces and influence maximum thallus size, including rate and timing of colonization, radial growth rates, environmental differences, thallus fusion, allelopathy, thallus mortality, colonization and competition. Comparative measurements of these variables on surfaces of known and unknown age may help to determine whether the basic assumptions of lichenometry are valid. Ultimately, it may be possible to take these differences into account when interpreting estimated dates
Antikaon condensation and the metastability of protoneutron stars
We investigate the condensation of meson along with
condensation in the neutrino trapped matter with and without hyperons.
Calculations are performed in the relativistic mean field models in which both
the baryon-baryon and (anti)kaon-baryon interactions are mediated by meson
exchange. In the neutrino trapped matter relevant to protoneutron stars, the
critical density of condensation is shifted considerably to higher
density whereas that of condensation is shifted slightly to higher
density with respect to that of the neutrino free case. The onset of
condensation always occurs earlier than that of condensation. A
significant region of maximum mass protoneutron stars is found to contain condensate for larger values of the antikaon potential. With the
appearance of condensation, there is a region of symmetric nuclear
matter in the inner core of a protoneutron star. It is found that the maximum
mass of a protoneutron star containing and condensate is
greater than that of the corresponding neutron star. We revisit the implication
of this scenario in the context of the metastability of protoneutron stars and
their evolution to low mass black holes.Comment: 26 pages; Revtex; 8 figures include
Exigência de proteína e composição da carcaça de galos reprodutores de 27 a 61 semanas de idade
Helium burning and neutron sources in the stars
Helium burning represents an important stage of stellar evolution as it contributes to the synthesis of key elements such as carbon, through the triple-alfa process, and oxygen, through the 12C(alfa, gamma)16O reaction. It is the ratio of carbon to oxygen at the end of the helium burning stage that governs the following phases of stellar evolution leading to different scenarios depending on the initial stellar mass. In addition, helium burning in Asymptotic Giant Branch stars, provides the two main sources of neutrons, namely the 13C(alfa, n)16O and the 22Ne(alfa, n)25Mg, for the synthesis of about half of all elements heavier than iron through the s-process. Given the importance of these reactions, much experimental work has been devoted to the study of their reaction rates over the last few decades. However, large uncertainties still remain at the energies of astrophysical interest which greatly limit the accuracy of stellar models predictions. Here, we review the current status on the latest experimental efforts and show how measurements of these important reaction cross sections can be significantly improved at next-generation deep underground laboratories
Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial
Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence. Patients and methods: Patients with resected AJCC stage IIB, IIC and III cutaneous melanoma were randomised to receive either adjuvant bevacizumab (7.5?mg/kg i.v. 3 weekly for 1?year) or standard observation. The primary end point was detection of an 8% difference in 5-year overall survival (OS) rate; secondary end points included disease-free interval (DFI) and distant metastasis-free interval (DMFI). Tumour and blood were analysed for prognostic and predictive markers. Results: Patients (n=1343) recruited between 2007 and 2012 were predominantly stage III (73%), with median age 56?years (range 18-88?years). With 6.4-year median follow-up, 515 (38%) patients had died [254 (38%) bevacizumab; 261 (39%) observation]; 707 (53%) patients had disease recurrence [336 (50%) bevacizumab, 371 (55%) observation]. OS at 5?years was 64% for both groups [hazard ratio (HR) 0.98; 95% confidence interval (CI) 0.82-1.16, P?=?0.78). At 5?years, 51% were disease free on bevacizumab versus 45% on observation (HR 0.85; 95% CI 0.74-0.99, P?=?0.03), 58% were distant metastasis free on bevacizumab versus 54% on observation (HR 0.91; 95% CI 0.78-1.07, P?=?0.25). Forty four percent of 682 melanomas assessed had a BRAFV600 mutation. In the observation arm, BRAF mutant patients had a trend towards poorer OS compared with BRAF wild-type patients (P?=?0.06). BRAF mutation positivity trended towards better OS with bevacizumab (P?=?0.21). Conclusions: Adjuvant bevacizumab after resection of high-risk melanoma improves DFI, but not OS. BRAF mutation status may predict for poorer OS untreated and potential benefit from bevacizumab. Clinical Trial Information: ISRCTN 81261306; EudraCT Number: 2006-005505-64
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype-phenotype map than previously anticipated.Molecular Epidemiolog
The spectral energy distribution of fermi bright blazars
We have conducted a detailed investigation of the broadband spectral properties of the γ-ray selected blazars of the Fermi LAT Bright AGN Sample (LBAS). By combining our accurately estimated Fermi γ-ray spectra with Swift, radio, infra-red, optical, and other hard X-ray/γ-ray data, collected within 3 months of the LBAS data taking period, we were able to assemble high-quality and quasi-simultaneous spectral energy distributions (SED) for 48 LBAS blazars. The SED of these γ-ray sources is similar to that of blazars discovered at other wavelengths, clearly showing, in the usual log ν-log ν Fν representation, the typical broadband spectral signatures normally attributed to a combination of low-energy synchrotron radiation followed by inverse Compton emission of one or more components. We have used these SED to characterize the peak intensity of both the low- and the high-energy components. The results have been used to derive empirical relationships that estimate the position of the two peaks from the broadband colors (i.e., the radio to optical, αro, and optical to X-ray, αox, spectral slopes) and from the γ-ray spectral index. Our data show that the synchrotron peak frequency (νSpeak) is positioned between 1012.5 and 1014.5 Hz in broad-lined flat spectrum radio quasars (FSRQs) and between 10 13 and 1017 Hz in featureless BL Lacertae objects. We find that the γ-ray spectral slope is strongly correlated with the synchrotron peak energy and with the X-ray spectral index, as expected at first order in synchrotron-inverse Compton scenarios. However, simple homogeneous, one-zone, synchrotron self-Compton (SSC) models cannot explain most of our SED, especially in the case of FSRQs and low energy peaked (LBL) BL Lacs. More complex models involving external Compton radiation or multiple SSC components are required to reproduce the overall SED and the observed spectral variability. While more than 50% of known radio bright high energy peaked (HBL) BL Lacs are detected in the LBAS sample, only less than 13% of known bright FSRQs and LBL BL Lacs are included. This suggests that the latter sources, as a class, may be much fainter γ-ray emitters than LBAS blazars, and could in fact radiate close to the expectations of simple SSC models. We categorized all our sources according to a new physical classification scheme based on the generally accepted paradigm for Active Galactic Nuclei and on the results of this SED study. Since the LAT detector is more sensitive to flat spectrum γ-ray sources, the correlation between νSpeak and γ-ray spectral index strongly favors the detection of high energy peaked blazars, thus explaining the Fermi overabundance of this type of sources compared to radio and EGRET samples. This selection effect is similar to that experienced in the soft X-ray band where HBL BL Lacs are the dominant type of blazars. © 2010 The American Astronomical Society
- …