The Development of the Student Advisory Board in the Master’s of Social Work Program at Eastern Kentucky University

Over the past six months, a selection of Masters of Social Work (MSW) students at Eastern Kentucky University (EKU) have been diving into program development mode through interprofessional collaboration to establish a firm foundation for the new Student Advisory Board (SAB). This capstone is an overview of the program planning from one student representative\u27s perspective within the interprofessional team. This capstone will provide an overview of the program\u27s development process, limitations, and suggestions for future directions. Attached is a copy of the SAB Handbook that was developed simultaneously with the capstone (see Appendix). Throughout the capstone, the SAB team will often be referred to as the “Team” to assume a collective whole

Taking Another Look: Light n-Capture Element Abundances in Metal-Poor Halo Stars

Elements are produced in stars through a variety of processes; some are well known, others are still the object of active research. The elements Zirconium (Zr) and Yttrium (Y) are produced via neutron capture (ncapture). These elements reside in the mass range where there is uncertainty about the production mechanism at early time. The rapid n-capture process (r-process) was believed to be responsible for the production, but no study (Burris et al 2000, Gilroy et al 1988 and others) has been able to successfully use the r-process to reproduce the abundance signature for elements in this mass range for metal-poor halo stars. It has been suggested (Sneden and Cowan 2003) that there may be an undiscovered component to the rprocess. New abundance calculations for these elements have been conducted for a sample of metalpoor halo stars. Transition probabilities for Zr II from (Malcheva et al.2006) and for YII from (Hannaford et al.1982) were utilized in these calculations as well as new high quality observational data from the Keck telescope. The new laboratory and observational data resulted in improvement in the abundance determinations and uncertainty of the abundances

Reflections on Litigating Holocaust Stolen Art Cases

In this Article we have attempted to provide an overview of the Nazi-looted art cases in their historical context. We have based the discussion on our knowledge and experience in litigating art law cases, particularly cases involving Nazi art looting, post-war restitution, and recent developments in art law. Any discussion of the legal implications of crimes committed by Nazi authorities during the Holocaust must begin with an obvious disclaimer. While bringing cases to recover artwork stolen by Nazi authorities is self-evidently a worthy pursuit, and while our firm is very proud to be intensively involved in this effort, we cannot even imagine the extent of the atrocities suffered by our clients\u27 ancestors (and our own) as a result of the high crimes committed against them. It is nonetheless humbly gratifying to work in this area of the law and to think that, in some small way, we are bringing comfort to the victims and their families. In the case of Mrs. Altmann, a vibrant and fascinating 89-year-old woman who vividly recalls the specific location in her uncle and aunt\u27s residence of each Klimt masterpiece she is seeking to recover, this sense of personal gratification is particularly high

Parameterized Littlewood-Paley operators with variable kernels on Hardy spaces and weak Hardy spaces

In this paper, by using the atomic decomposition theory of Hardy space and weak Hardy space, we discuss the boundedness of parameterized Littlewood-Paley operator with variable kernel on these spaces.Comment: 15 pages. arXiv admin note: text overlap with arXiv:1711.0961

Tarnished Plant Bugs in Cotton (Research Information Sheet #101)

This publication describes tarnished plant bugs and includes information on damage, biology, varietal susceptibility, monitoring, insecticide resistance and efficacy.https://digitalcommons.lsu.edu/agcenter_researchinfosheets/1010/thumbnail.jp

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type cohorts.Patients and methodsEligible patients had Child-Pugh A liver function and ≤1 prior systemic anticancer regimen, completed ≥4 weeks before study entry. The cabozantinib starting dose was 100 mg daily. After an initial 12-week cabozantinib treatment period, patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0 were randomized to cabozantinib or placebo. The primary endpoint of the lead-in stage was objective response rate (ORR) at week 12, and the primary endpoint of the randomized stage was progression-free survival (PFS).ResultsAmong the 41 HCC patients enrolled, the week 12 ORR was 5%, with 2 patients achieving a confirmed partial response (PR). The week 12 disease control rate (PR or SD) was 66% (Asian subgroup: 73%). Of patients with ≥1 post-baseline scan, 78% had tumor regression, with no apparent relationship to prior sorafenib therapy. Alpha-fetoprotein (AFP) response (>50% reduction from baseline) occurred in 9 of the 26 (35%) patients with elevated baseline AFP and ≥1 post-baseline measurement. Twenty-two patients with SD at week 12 were randomized. Median PFS after randomization was 2.5 months with cabozantinib and 1.4 months with placebo, although this difference was not statistically significant. Median PFS and overall survival from Day 1 in all patients were 5.2 and 11.5 months, respectively. The most common grade 3/4 adverse events, regardless of attribution, were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Dose reductions were utilized in 59% of patients.ConclusionsCabozantinib has clinical activity in HCC patients, including objective tumor responses, disease stabilization, and reductions in AFP. Adverse events were managed with dose reductions.Trial registration numberNCT00940225

A Longitudinal Study of the Reciprocal Relationship Between Ever Smoking and Urgency in Early Adolescence

Background—Among early adolescents in the United States (U.S.), the prevalence of cigarette smoking is at its lowest level in recent decades. Nonetheless, given the risks of smoking in early development, it remains critically important to study both risk factors for smoking and risks from smoking. This longitudinal study with U.S. early adolescents examines smoking initiation and tests a model of reciprocal prediction between ever smoking and the personality trait of urgency (i.e., mood-based impulsivity), a trait that increases risk for multiple forms of dysfunction. Methods—Participants (n=1906; 90% 10–11 years old, 50% female, 39% racial minorities at baseline) completed questionnaires 1–2 times per year starting in 5th grade and ending in 9th grade. Structural equation modeling allowed tests of bidirectional relationships between ever smoking and urgency controlling for pubertal status and negative affect at each wave. Results—Incidence of ever smoking increased from 5% to 27% over time, with current smoking around 5% at the last wave. Urgency at each wave predicted ever smoking at the next wave above and beyond covariates and prior smoking (all p \u3c .01). Likewise, with one exception, ever smoking predicted an increase in urgency at the subsequent wave above and beyond covariates and prior urgency (all p \u3c .05). Conclusion—Results show that risk for smoking increases with higher levels of urgency and urgency increases secondary to engagement in smoking. Future work should therefore explore urgency as a point of prevention for smoking and smoking cessation as a means to mitigate mood-based impulsivity

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cognitive function in mouse models. The effect of enhanced REV-ERB activity on cognitive function has not been examined. In this study, we tested the hypothesis that enhanced REV-ERB function may enhance cognitive function in a model of Alzheimer’s disease. We utilized the REV-ERB agonist SR9009 to pharmacologically activate the activity of REV-ERB in the SAMP8 mouse model of Alzheimer’s disease. SR9009 reversed cognitive dysfunction of an aged SAMP8 mouse in several behavioral assays including novel object recognition, T-maze foot shock avoidance, and lever press operant conditioning task assessments. SR9009 treatment reduced amyloid-β 1–40 and 1–42 levels in the cortex, which is consistent with improved cognitive function. Furthermore, SR9009 treatment led to increased hippocampal PSD-95, cortical synaptophysin expression and the number of synapses suggesting improvement in synaptic function. We conclude that REV-ERB is a potential target for treatment of Alzheimer’s disease.</div