Optical and Radio Polarimetry of the M87 Jet at 0.2" Resolution

We discuss optical (HST/WFPC2 F555W) and radio (15 GHz VLA) polarimetry observations of the M87 jet taken during 1994-1995. Many knot regions are very highly polarized ($\sim 40-50$, approaching the theoretical maximum for optically thin synchrotron radiation), suggesting highly ordered magnetic fields. High degrees of polarization are also observed in interknot regions. While the optical and radio polarization maps share many similarities, we observe significant differences between the radio and optical polarized structures, particularly for bright knots in the inner jet, giving us important insight into the jet's radial structure. Unlike in the radio, the optical magnetic field position angle becomes perpendicular to the jet at the upstream ends of knots HST-1, D, E and F. Moreover, the optical polarization decreases markedly at the position of the flux maxima in these knots. In contrast, the magnetic field position angle observed in the radio remains parallel to the jet in most of these regions, and the decreases in radio polarization are smaller. More minor differences are seen in other jet regions. Many of the differences between optical and radio polarimetry results can be explained in terms of a model whereby shocks occur in the jet interior, where higher-energy electrons are concentrated and dominate both polarized and unpolarized emissions in the optical, while the radio maps show strong contributions from lower-energy electrons in regions with {\bf B} parallel, near the jet surface.Comment: 28 pages, 7 figures; accepted for publication in AJ (May 1999

A statistical mechanics approach to autopoietic immune networks

The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may stem. In order to make theoretical immunology appealing to the statistical physicist audience we are going to work out a research article which, from one side, may hopefully act as a benchmark for future improvements and developments, from the other side, it is written in a very pedagogical way both from a theoretical physics viewpoint as well as from the theoretical immunology one. Furthermore, we have chosen to test our model describing a wide range of features of the adaptive immune response in only a paper: this has been necessary in order to emphasize the benefit available when using disordered statistical mechanics as a tool for the investigation. However, as a consequence, each section is not at all exhaustive and would deserve deep investigation: for the sake of completeness, we restricted details in the analysis of each feature with the aim of introducing a self-consistent model.Comment: 22 pages, 14 figur

Random variation in rectal position during radiotherapy for prostate cancer is two to three times greater than that predicted from prostate motion.

OBJECTIVE: Radiotherapy for prostate cancer does not explicitly take into account daily variation in the position of the rectum. It is important to accurately assess accumulated dose (DA) to the rectum in order to understand the relationship between dose and toxicity. The primary objective of this work was to quantify systematic (Σ) and random (σ) variation in the position of the rectum during a course of prostate radiotherapy. METHODS: The rectum was manually outlined on the kilo-voltage planning scan and 37 daily mega-voltage image guidance scans for 10 participants recruited to the VoxTox study. The femoral heads were used to produce a fixed point to which all rectal contours were referenced. RESULTS: Σ [standard deviation (SD) of means] between planning and treatment was 4.2 mm in the anteroposterior (AP) direction and 1.3 mm left-right (LR). σ (root mean square of SDs) was 5.2 mm AP and 2.7 mm LR. Superior-inferior variation was less than one slice above and below the planning position. CONCLUSION: Our results for Σ are in line with published data for prostate motion. σ, however, was approximately twice as great as that seen for prostate motion. This suggests that DA may differ from planned dose in some patients treated with radiotherapy for prostate cancer. ADVANCES IN KNOWLEDGE: This work is the first to use daily imaging to quantify Σ and σ of the rectum in prostate cancer. σ was found to be greater than published data, providing strong rationale for further investigation of individual DA.JS is supported by Cancer Research UK through the Cambridge Cancer Centre. NGB is supported by the NIHR Cambridge Biomedical Research Centre. VoxTox is funded by Cancer Research UK.This is the final published version. It was first available from the British Institute of Radiology at http://dx.doi.org/10.1259/bjr.2014034

Multifrequency Radiation of Extragalactic Large-Scale Jets

Large-scale extragalactic jets, observed to extend from a few to a few hundred kiloparsecs from active galactic nuclei, are now studied over many decades in frequency of electromagnetic spectrum, from radio until (possibly) TeV gamma rays. For hundreds of known radio jets, only about 25 are observed at optical frequencies. Most of them are relatively short and faint, with only a few exceptions, like 3C 273 or M 87, allowing for detailed spectroscopic and morphological studies. Somewhat surprisingly, the large-scale jets can be very prominent in X-rays. Up to now, about 25 jets were detected within the 1 - 10 keV energy range, although the nature of this emission is still under debate. In general, both optical and X-ray jet observations present serious problems for standard radiation models for the considered objects. Recent TeV observations of M 87 suggest the possibility of generating large photon fluxes at these high energies by its extended jet. In this paper we summarize information about multiwavelength emission of the large-scale jets, and we point out several modifications of the standard jet radiation models (connected with relativistic bulk velocities, jet radial stratification and particle energization all the way along the jet), which can possibly explain some of the mentioned puzzling observations. We also comment on gamma-ray emission of the discussed objects.Comment: 29 pages. Modified version, accepted for publication in Chinese Journal of Astronomy and Astrophysic

Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.

BACKGROUND: Numerous germline single-nucleotide polymorphisms increase susceptibility to prostate cancer, some lying near genes involved in cellular radiation response. This study investigated whether prostate cancer patients with a high genetic risk have increased toxicity following radiotherapy. METHODS: The study included 1560 prostate cancer patients from four radiotherapy cohorts: RAPPER (n=533), RADIOGEN (n=597), GenePARE (n=290) and CCI (n=150). Data from genome-wide association studies were imputed with the 1000 Genomes reference panel. Individuals were genetically similar with a European ancestry based on principal component analysis. Genetic risks were quantified using polygenic risk scores. Regression models tested associations between risk scores and 2-year toxicity (overall, urinary frequency, decreased stream, rectal bleeding). Results were combined across studies using standard inverse-variance fixed effects meta-analysis methods. RESULTS: A total of 75 variants were genotyped/imputed successfully. Neither non-weighted nor weighted polygenic risk scores were associated with late radiation toxicity in individual studies (P>0.11) or after meta-analysis (P>0.24). No individual variant was associated with 2-year toxicity. CONCLUSION: Patients with a high polygenic susceptibility for prostate cancer have no increased risk for developing late radiotherapy toxicity. These findings suggest that patients with a genetic predisposition for prostate cancer, inferred by common variants, can be safely treated using current standard radiotherapy regimens

Equilibrium statistical mechanics on correlated random graphs

Biological and social networks have recently attracted enormous attention between physicists. Among several, two main aspects may be stressed: A non trivial topology of the graph describing the mutual interactions between agents exists and/or, typically, such interactions are essentially (weighted) imitative. Despite such aspects are widely accepted and empirically confirmed, the schemes currently exploited in order to generate the expected topology are based on a-priori assumptions and in most cases still implement constant intensities for links. Here we propose a simple shift in the definition of patterns in an Hopfield model to convert frustration into dilution: By varying the bias of the pattern distribution, the network topology -which is generated by the reciprocal affinities among agents - crosses various well known regimes (fully connected, linearly diverging connectivity, extreme dilution scenario, no network), coupled with small world properties, which, in this context, are emergent and no longer imposed a-priori. The model is investigated at first focusing on these topological properties of the emergent network, then its thermodynamics is analytically solved (at a replica symmetric level) by extending the double stochastic stability technique, and presented together with its fluctuation theory for a picture of criticality. At least at equilibrium, dilution simply decreases the strength of the coupling felt by the spins, but leaves the paramagnetic/ferromagnetic flavors unchanged. The main difference with respect to previous investigations and a naive picture is that within our approach replicas do not appear: instead of (multi)-overlaps as order parameters, we introduce a class of magnetizations on all the possible sub-graphs belonging to the main one investigated: As a consequence, for these objects a closure for a self-consistent relation is achieved.Comment: 30 pages, 4 figure

First AMBER/VLTI observations of hot massive stars

AMBER is the first near infrared focal instrument of the VLTI. It combines three telescopes and produces spectrally resolved interferometric measures. This paper discusses some preliminary results of the first scientific observations of AMBER with three Unit Telescopes at medium (1500) and high (12000) spectral resolution. We derive a first set of constraints on the structure of the circumstellar material around the Wolf Rayet Gamma2 Velorum and the LBV Eta Carinae

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited