Coping with cognitive impairment in people with Parkinson’s disease and their carers: a qualitative study

Cognitive impairment is common in Parkinson’s disease (PD). However, the psychosocial impact of living and coping with PD and cognitive impairment in people with PD and their carers have not been explored. This paper draws on a qualitative study that explores the subjective impact of cognitive impairment on people with PD and their carers. Thirty-six one-to-one interviews were completed; people with PD were from three groups: normal cognition, mild cognitive impairment and dementia. Data collection and analysis were iterative and verbatim transcripts were analysed using thematic analysis. Themes were interpreted in consultation with coping and adaptation theory. The analysis revealed four main themes: threats to identity and role, pre-death grief and feelings of loss in carers, success and challenges to coping in people with PD, and problem focused coping and finding meaning in caring. Our data highlights how cognitive impairment can threaten an individual’s self-perception and their perceived role; the ostensible effects depended on the impact individual’s perceived cognitive impairment on their daily lives. For carers, cognitive impairment had a greater emotional impact compared to the physical symptoms of PD. The discussion that developed around protective factors provides possible opportunities for future interventions, such as psychological therapies to improve successful adjustment

Electrochemically tuneable multi-colour electrochemiluminescence using a single emitter

A single starting component electrochemiluminescence system from which red, green, blue or white emission can be obtained, depending on the applied potential or the mode of the ECL experiment, is described. The convoluted ECL spectral responses observed at different potentials are readily explained using a 3D-ECL technique, where the ECL spectral profile is continuously monitored as a function of potential during voltammetric scanning. The 3D plots obtained using this technique implicate cross-annihilation ECL reactions involving the complex itself and stable products resulting from its electrolysis. Combining this information with knowledge of the energetic requirements of the various reactions involved, suggests a mechanism involving traces of two emissive products, related to the loss of a methyl group from the triazole moiety. These products, while barely detectable electrochemically, are sufficiently emissive to influence and even dominate the ECL emission under some conditions

The nature and role of trap states in a dendrimer-based organic field-effect transistor explosive sensor

We report the fabrication and charge transport characterization of carbazole dendrimer-based organic field-effect transistors (OFETs) for the sensing of explosive vapors. After exposure to para-nitrotoluene (pNT) vapor, the OFET channel carrier mobility decreases due to trapping induced by the absorbed pNT. The influence of trap states on transport in devices before and after exposure to pNT vapor has been determined using temperature-dependent measurements of the field-effect mobility. These data clearly show that the absorption of pNT vapor into the dendrimer active layer results in the formation of additional trap states. Such states inhibit charge transport by decreasing the density of conducting states. (C) 2013 AIP Publishing LLC

Annealing-enhanced birefringence and aggregation in MEH-PPV : a spectroscopic ellipsometry study

Funding: UK EPSRC (GR/S62628/01) and Royal Society Wolfson Research Merit Award (I.D.W.S.).We have used absorption, photoluminescence (PL) and variable angle spectroscopic ellipsometry (VASE) measurements to investigate the structural changes that take place upon high temperature annealing in spin-coated films of the prototypical conjugated polymer (CP) poly[2-(2’-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene] (MEH-PPV). Absorption and VASE measurements reveal that the birefringence of the films increases by approximately a factor of two upon heating, which indicates significant increase in the alignment of the conjugated polymer (CP) strands within the film plane. Absorption and PL spectra indicate the formation in annealed films of interchain species having lower energy transitions. But these measurements alone do not reveal the type of interchain species formed, such as excimers or aggregates. VASE measurements were used to investigate this feature and clearly reveal a new, low energy, feature with a shoulder at 650 nm in the dispersion relations of the extraordinary (out-of-plane) extinction and absorption coefficients of annealed films, which we assign to aggregate absorption. Thus, our work shows that VASE is a sensitive enough technique to measure aggregate absorption in CP films. In the case of the ordinary (in-plane) extinction and absorption coefficients, there is increased amplitude of the lower energy peak upon heating, owing to increased uniaxial anisotropy, along with a broadening and a longer red-tail, but the well-resolved red-shifted absorption band seen for the extraordinary absorption coefficient, is not observed. Therefore, we conclude that while in-plane and out-of-plane aggregation occurs in annealed spin-coated films of MEH-PPV, aggregate absorption is only clearly observed when the aggregate electronic transition dipole is oriented preferentially in a direction perpendicular to the film plane. This conclusion is consistent with the usual observation that aggregate absorption in MEH-PPV films is not easily observed using absorption spectra alone, which are typically measured at normal incidence.PostprintPeer reviewe

Changes in flood events inferred from centennial length streamflow data records

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.advwatres.2018.08.017 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/This research examines ways that climate change may alter the risk of flooding in cold regions focusing on changes in the flood regimes and changes and shifts in the dominant flood generating processes at 27 natural watersheds across Canada and the northern United States. Changes in flood regimes are examined using data from long term hydrometric reference streamflow gauging stations whose data record spans the past 100 years; stations included are considered to have good quality data and were screened to avoid the influences of regulation, diversions, or land use change. Changes in flood regimes are complex and require different approaches to properly characterize the variety of changes that have occurred and are likely to occur in the future. Peaks over threshold data are used to explore changes to the magnitude, timing, volume and duration of threshold exceedences. Circular statistics are used to explore changes in the nature of the flood regime based on changes in the timing and regularity of flood threshold exceedences. All flood regimes show an increased number of threshold exceeding events. An increased prevalence of rainfall flood responses is observed as flood events occur more often during the rainfall dominated portion of the seasonal cycle resulting in a shift for nival regime stations to a more mixed regime and for mixed regime stations towards a more pluvial regime. The results support viewing hydrologic regime as a continuum from nival to pluvial with several stations shifting towards the pluvial end.Natural Sciences and Engineering Research Council of Canada ["NETGP 451456"

Designing brutal multiplayer video games

Non-digital forms of play that allow players to direct brute force directly upon each other, such as martial arts, boxing and full contact team sports,are very popular. However, inter-player brutality has largely been unexplored as a feature of digital gaming. In this paper, we describe the design and study of 2 multi-player games that encourage players to use brute force directly against other players. Balance of Poweris a tug-of-war style game implemented with Xbox Kinect, while Bundleis a playground-inspired chasing game implemented with smartphones. Two groups of five participants(n=10) played both games while being filmed, and were subsequently interviewed. A thematic analysis identified five keycomponents ofthe brutalmultiplayer video gameexperience, which informsa set of sevendesign considerations.This work aims to inspire the design of engaging game experiences based on awareness and enjoyment of our own and others’ physicality

Large area monolithic organic solar cells

Although efficiencies of > 10% have recently been achieved in laboratory-scale organic solar cells, these competitive performance figures are yet to be translated to large active areas and geometries relevant for viable manufacturing. One of the factors hindering scale-up is a lack of knowledge of device physics at the sub-module level, particularly cell architecture, electrode geometry and current collection pathways. A more in depth understanding of how photocurrent and photovoltage extraction can be optimised over large active areas is urgently needed. Another key factor suppressing conversion efficiencies in large area cells is the relatively high sheet resistance of the transparent conducting anode typically indium tin oxide. Hence, to replace ITO with alternative transparent conducting anodes is also a high priority on the pathway to viable module-level organic solar cells. In our paper we will focus on large area devices relevant to sub-module scales - 5 cm x 5 cm monolithic geometry. We have applied a range of experimental techniques to create a more comprehensive understanding of the true device physics that could help make large area, monolithic organic solar cells more viable. By employing this knowledge, a novel transparent anode consisting of molybdenum oxide (MoOx) and silver (Ag) is developed to replace ITO and PEDOT-free large area solar cell sub-modules, acting as both a transparent window and hole-collecting electrode. The proposed architecture and anode materials are well suited to high throughput, low cost all-solution processing

Effect of precursor macromonomer molecular weight on poly(dimethylsiloxane) film morphology and nitroaromatic vapor sorption

The capability to detect nitro-based explosives from their vapor is often limited by their low vapor pressure. One approach for overcoming this limitation is to use a solid-state pre-concentrator. The sorption and desorption of nitroaromatic vapors by poly(dimethylsiloxane)-based (PDMS) films fabricated from three different molecular weights of hydroxy-terminated poly(dimethylsiloxane) (HO-PDMS) macromonomers has been investigated. It was found that independent of macromonomer molecular weight, all the PDMS films were able to sorb nitro-based explosive analyte. However, for PDMS films of similar thickness, those formed from the lowest molecular weight macromonomer sorbed the least analyte and had the poorest retention capability. Atomic Force Microscopy (AFM) suggested that at least a proportion of the analyte was adsorbed onto the surface of the PDMS film formed from the low molecular weight macromonomer. PDMS films from the higher molecular weight macromonomers sorb more analyte with the vapor diffusing into the bulk of the film. PDMS films formed from the 750 cSt macromonomer were found to have the best analyte sorption and retention properties. The best pre-concentrator film was determined to increase the available analyte for vapor detection by up to 2 orders of magnitude. (C) 2018 Elsevier B.V. All rights reserved

Reference hydrologic networks II: using reference hydrologic networks to assess climate-driven changes in streamflow

Reference hydrologic networks (RHNs) can play an important role in monitoring for changes in the hydrological regime related to climate variation and change. Currently, the literature concerning hydrological response to climate variations is complex and confounded by the combinations of many methods of analysis, wide variations in hydrology, and the inclusion of data series that include changes in land use, storage regulation and water use in addition to those of climate. Three case studies that illustrate a variety of approaches to the analysis of data from RHNs are presented and used, together with a summary of studies from the literature, to develop approaches for the investigation of changes in the hydrological regime at a continental or global scale, particularly for international comparison. We present recommendations for an analysis framework and the next steps to advance such an initiative. There is a particular focus on the desirability of establishing standardized procedures and methodologies for both the creation of new national RHNs and the systematic analysis of data derived from a collection of RHNs