580 research outputs found

    PND39 AGREEMENT BETWEEN MULTIPLE SCLEROSIS-RELATED VARIABLES IN MEDICAL CHARTS AND CLAIMS DATA

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    PND26 Estimated Costs of First-Year Monitoring and Administration of Multiple Sclerosis Therapies in the United States

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    Corn particle size and pelleting influence on growth performance, fecal shedding, and lymph node infection rates of salmonella enterica serovar typhimurium

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    Ninety-six pigs (initially 13.8 lb.) were used in a 28-d trial to determine the interactive effects between pelleting and particle size on Salmonella serovar Typhimurium shedding and colonization in a young growing pig model. The experiment was a 2 × 2 factorial arrangement consisting of meal or pelleted diets with fine or coarse ground corn. Pigs were fed the diets 1 wk pre-salmonella inoculation and allotted based on weight to one of four dietary treatments. For the main effect of particle size, pigs fed finer ground corn had significantly improved feed efficiency (P0.82). There was no difference in salmonella infection rates of mesenteric lymph nodes obtained on d 28 between treatments or main effects. Finer grinding and meal diets generally improved growth, feed intake, and feed efficiency compared to pigs fed coarser ground or pelleted feeds. However, particle size or diet form did not alter fecal shedding or mesenteric lymph node infection rates of salmonella organisms in our study

    Porcine Reproductive and Respiratory Syndrome virus reduces feed efficiency, digestibility, and lean tissue accretion in grow-finish pigs

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    Porcine reproductive and respiratory syndrome (PRRS) virus is a major swine virus that causes reproductive impairment in sows, as well as respiratory disease, reduction in growth rates, and mortalities in all ages of pigs. The objective of this study was to quantify the impact PRRS has on grower-finisher pig feed efficiency and tissue accretion rates. Thirty PRRS naïve, littermate pairs of maternal line Choice Genetics gilts (33.6 ± 0.58 kg BW) were selected and pairs split across 2 barns consisting of 5 pens (n = 6 pigs/pen per barn). Pigs in both barns were fed corn-soybean-DDGS diets ad libitum. All pigs in one barn were inoculated (CHAL) via an i.m. injection of a live PRRS strain isolated from the region (0 d post inoculation, dpi), while pigs in the other barn were given a saline control injection (CONT). Pig performance (ADG, ADFI, G:F) was assessed from 35 kg BW until each group reached market BW (128 kg). Additionally, longitudinal apparent total tract digestibility (ATTD) and body composition was assessed using Dual-energy X-ray absorptiometry (DXA) post inoculation (dpi) to estimate lean, protein, fat and bone accretion rates. Serological data from CHAL pigs showed that PRRS titers peaked 7 dpi and these pigs seroconverted by 35 dpi. According to both genomic and protein PRRS titers, CONT pigs were naïve to CHAL throughout the study. The PRRS infection reduced (P \u3c 0.001) ATTD of dry matter, energy and nitrogen by 3 to 5% at 21 dpi and the reduction in ATTD persisted after 65 dpi. Compared to the CONT, CHAL pigs had decreased ADG (0.89 vs. 0.80 kg/d, P \u3c 0.001), ADFI (2.05 vs. 1.93 kg/d, P \u3c 0.001), and G:F (0.44 vs. 0.41 kg/d, P \u3c 0.001) over the entire test period. The CHAL pigs also had attenuated DXA predicted whole body accretion of lean (547 vs. 633 g/d, P = 0.001), protein (109 vs. 126 g/d, P = 0.001) and fat (169 vs. 205 g/d, P = 0.001) compared to their CONT counterparts from dpi 0 to 80. Based on carcass data at slaughter (and consistent with the DXA data), CHAL pigs had leaner carcasses and reduced yields. These data clearly demonstrate that PRRS infection reduces digestibility, feed efficiency and protein accretion rates in grower-finisher pigs

    Beta-delayed-neutron studies of 135,136^{135,136}Sb and 140^{140}I performed with trapped ions

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    Beta-delayed-neutron (β\betan) spectroscopy was performed using the Beta-decay Paul Trap and an array of radiation detectors. The β\betan branching ratios and energy spectra for 135,136^{135,136}Sb and 140^{140}I were obtained by measuring the time of flight of recoil ions emerging from the trapped ion cloud. These nuclei are located at the edge of an isotopic region identified as having β\betan branching ratios that impact the r-process abundance pattern around the A~130 peak. For 135,136^{135,136}Sb and 140^{140}I, β\betan branching ratios of 14.6(11)%, 17.6(28)%, and 7.6(28)% were determined, respectively. The β\betan energy spectra obtained for 135^{135}Sb and 140^{140}I are compared with results from direct neutron measurements, and the β\betan energy spectrum for 136^{136}Sb has been measured for the first time

    β -decay half-lives of Sb 134,134m and their isomeric yield ratio produced by the spontaneous fission of Cf 252

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    A number of fission products possess isomeric states which have a nuclear spin significantly different from that of the ground state. The yield ratio of these states following fission is influenced by the angular momentum present in the fissioning system. The Sb134m,134 yield ratio had not been previously measured in the spontaneous fission of Cf252; however, it had previously been observed to favor the (7-) isomer over the (0-) ground state in U235(nth,f) and Th232(25 MeV p,f). Using a mass-separated beam of low-energy Sb134,134m ions produced by Cf252 spontaneous fission at the CARIBU facility, β particles and γ rays were detected using the SATURN/X-Array decay station to determine the fission-yield ratio and β-decay half-lives. The Sb134m to Sb134 fission yield was determined to be 2.03±0.05 and the half-lives of Sb134m and Sb134 were found to be 9.87±0.08 s and 0.674±0.004 s, respectively. These results represent the first isomeric yield ratio measurement for this nucleus, and improved measurements of the Sb134 ground state and the Sb134m isomer half-lives

    Astrophysical structures from primordial quantum black holes

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    The characteristic sizes of astrophysical structures, up to the whole observed Universe, can be recovered, in principle, assuming that gravity is the overall interaction assembling systems starting from microscopic scales, whose order of magnitude is ruled by the Planck length and the related Compton wavelength. This result agrees with the absence of screening mechanisms for the gravitational interaction and could be connected to the presence of Yukawa corrections in the Newtonian potential which introduce typical interaction lengths. This result directly comes out from quantization of primordial black holes and then characteristic interaction lengths directly emerge from quantum field theory.Comment: 11 page

    Effects of Crystalline Amino Acid Concentrations With or Without Formaldehyde Treatment of Diets on Nursery Pig Growth Performance and Fecal Bacterial Concentration

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    A total of 1,235 nursery pigs (PIC 359 × 1050; initially 26.9 lb BW) were used in a 28-d study evaluating the effects of crystalline amino acid concentrations with or without formaldehyde treatment of diets on nursery pig growth performance, feed bacteria concentration, lysine content, and fecal microbial diversity. Sal CURB (Kemin Industries Inc., Des Moines, IA) is a commercial formaldehyde product that is commonly utilized in the poultry industry for Salmonella control in feed but has also been shown to reduce PEDV infectivity in swine diets.Pigs were weaned at approximately 21 d, fed a common starter diet for 10 d, and allotted to pens based on BW in a completely randomized design. Experimental diets were fed in 2 phases (phase 1, d 0 to 12; and phase 2, 12 to 28 post-weaning) in meal form. Experimental treatments were arranged as a 2 × 2 + 1 factorial with main effects of formaldehyde (none vs. 0.30% in all phases) and crystalline AA concentration (low vs. high) plus a positive control. The positive control represented this current production system’s formulated Lys requirement needed to maximize performance, whereas treatment diets were formulated at 80% of the positive control’s lysine concentration. Feed bacterial concentration was determined by performing aerobic plate, Enterobacteriaceae, and total coliform counts on composited feed samples collected from each batch of feed manufactured at the feed mill and directly from feeders at the farm. Total, available, and free Lys analyses were conducted on composited feed samples collected from each phase of the study to determine Lys content. A composite fecal sample was collected from 3 randomly selected pigs per pen on d 28 for each treatment, DNA isolated, and each sample assessed for bacterial community analysis.Overall, a significant crystalline AA × formaldehyde interaction (P \u3c 0.05) was observed for ADFI and F/G. The interaction for ADFI was because added formaldehyde in high crystalline AA diets decreased feed intake; however, in low crystalline AA diets, ADFI was unchanged. For F/G, pigs had improved F/G in low crystalline AA diets without formaldehyde, but no difference was observed in high crystalline AA diets. Despite the interaction for ADFI and F/G, formaldehyde-treated diets reduced (P \u3c 0.05) ADG, ADFI, and resulted in poorer F/G. Crystalline AA concentration did not impact performance. Added formaldehyde reduced or eliminated bacterial concentration of complete feed in phase 1 of the study. Formaldehyde reduced total and available Lys in both low and high crystalline AA diets, with a greater reduction occurring in low crystalline AA diets, but had no effect on free Lys. Added formaldehyde reduced (P = 0.001) Lactobacillaceae bacterial species, but increased (P = 0.001) Clostridiaceae bacterial species in fecal microbial samples. As expected, formaldehyde treatment reduced bacterial microflora of complete feeds. Overall, the level of crystalline AA did not impact performance while the nursery diet formaldehyde addition negatively influenced growth performance, AA utilization, and fecal microbial diversity
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