Fearing an Inhuman(e) Future: The Unliterary or Illiterate Dystopia of Aldous Huxley’s Brave New World

Though not necessarily recognized as a major canonical work of English literature, Aldous Huxley’s 1932 novel Brave New World is the paradigm of the modern social satire. The novel, a combination of dystopia, satire, science fiction and perhaps more, is set in the distant yet horrifyingly familiar future of A.F. 632 (Year of our Ford). In this time, Huxley depicts a supposed utopian world free of problems. Nevertheless, the novel also shows how this modern human society’s elimination of problems eliminates its humanity. My thesis specifically focuses on the elimination of humanity as manifested in the lack of literature and literacy throughout the novel. Huxley’s use of allusion and parody, almost Joycean, to other great literature of the past sets his novel apart from others like it and makes the work truly universal and lasting

Some practical suggestions for improving engagement between researchers and policy-makers in natural resource management

Policy-makers and managers in natural resource management (NRM) often complain that researchers are out of touch. Researchers often complain that policy-makers and managers make poorly informed decisions. In this article, we report on a meeting between researchers, policy-makers and managers convened to identify practical solutions to improve engagement between these camps. A necessary starting point is that every researcher and policy-maker should understand, and tap into, the motivations and reward systems of the other when seeking engagement. For example, researchers can be motivated to engage in policy development if there is a promise of outputs that align with their reward systems such as co-authored publications. Successful research-policy partnerships are built around personal relationships. As a researcher, you cannot therefore expect your results to inform policy by only publishing in journals. As a policy-maker, you cannot guarantee engagement from researchers by publicly inviting comment on a document. Actively building and maintaining relationships with key individuals through discussions, meetings, workshops or field days will increase the likelihood that research outcomes will inform policy decisions. We identified secondments, sabbaticals, fellowships and 'buddies', an annual national NRM conference and 'contact mapping' (a Facebook-type network) as forums that can catalyse new relationships between researchers and policy-makers. We challenge every researcher, policy-maker and manager in NRM to build one new cross-cultural relationship each year

80 questions for UK biological security.

Multiple national and international trends and drivers are radically changing what biological security means for the United Kingdom (UK). New technologies present novel opportunities and challenges, and globalisation has created new pathways and increased the speed, volume and routes by which organisms can spread. The UK Biological Security Strategy (2018) acknowledges the importance of research on biological security in the UK. Given the breadth of potential research, a targeted agenda identifying the questions most critical to effective and coordinated progress in different disciplines of biological security is required. We used expert elicitation to generate 80 policy-relevant research questions considered by participants to have the greatest impact on UK biological security. Drawing on a collaboratively-developed set of 450 questions, proposed by 41 experts from academia, industry and the UK government (consulting 168 additional experts) we subdivided the final 80 questions into six categories: bioengineering; communication and behaviour; disease threats (including pandemics); governance and policy; invasive alien species; and securing biological materials and securing against misuse. Initially, the questions were ranked through a voting process and then reduced and refined to 80 during a one-day workshop with 35 participants from a variety of disciplines. Consistently emerging themes included: the nature of current and potential biological security threats, the efficacy of existing management actions, and the most appropriate future options. The resulting questions offer a research agenda for biological security in the UK that can assist the targeting of research resources and inform the implementation of the UK Biological Security Strategy. These questions include research that could aid with the mitigation of Covid-19, and preparation for the next pandemic. We hope that our structured and rigorous approach to creating a biological security research agenda will be replicated in other countries and regions. The world, not just the UK, is in need of a thoughtful approach to directing biological security research to tackle the emerging issues.The David and Claudia Harding Foundation for provided funding for the BioRISC project. Arcadia provided support in the form of salaries for authors WS. and CR. TM and HS are affiliated with Opencell. KM is affiliated with Biosecure Ltd. The funders did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.

Advantages and limitations of quantitative PCR (Q-PCR)-based approaches in microbial ecology

Quantitative PCR (Q-PCR or real-time PCR) approaches are now widely applied in microbial ecology to quantify the abundance and expression of taxonomic and functional gene markers within the environment. Q-PCR-based analyses combine 'traditional' end-point detection PCR with fluorescent detection technologies to record the accumulation of amplicons in 'real time' during each cycle of the PCR amplification. By detection of amplicons during the early exponential phase of the PCR, this enables the quantification of gene (or transcript) numbers when these are proportional to the starting template concentration. When Q-PCR is coupled with a preceding reverse transcription reaction, it can be used to quantify gene expression (RT-Q-PCR). This review firstly addresses the theoretical and practical implementation of Q-PCR and RT-Q-PCR protocols in microbial ecology, highlighting key experimental considerations. Secondly, we review the applications of (RT)-Q-PCR analyses in environmental microbiology and evaluate the contribution and advances gained from such approaches. Finally, we conclude by offering future perspectives on the application of (RT)-Q-PCR in furthering understanding in microbial ecology, in particular, when coupled with other molecular approaches and more traditional investigations of environmental systems. © 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved

The right to unionise, the right to bargain and the right to democratic policing

This (normative) article explores the importance of police unions in the quest for democratic policing. The authors argue that if we are to expect police to behave democratically, it is important for police themselves to experience democratic engagement within the organizations in which they work. That is, if police are expected to defend democracy, they should not be denied basic democratic rights such as the right to collective bargaining and the right to freedom of association. The authors contend that police unions, through networking with other social justice groupings and through encouraging democratic practice, constitute a real forum for the promotion of democratic policing. For this potential to be reached, however, police unions need to identify with broader labor movement trends toward community unionism

Using clinical research networks to assess severity of an emerging influenza pandemic

BACKGROUND: Early clinical severity assessments during the 2009 influenza A H1N1 pandemic (pH1N1) overestimated clinical severity due to selection bias and other factors. We retrospectively investigated how to use data from the International Network for Strategic Initiatives in Global HIV Trials, a global clinical influenza research network, to make more accurate case fatality ratio (CFR) estimates early in a future pandemic, an essential part of pandemic response. METHODS: We estimated the CFR of medically attended influenza (CFRMA) as the product of probability of hospitalization given confirmed outpatient influenza and the probability of death given hospitalization with confirmed influenza for the pandemic (2009-2011) and post-pandemic (2012-2015) periods. We used literature survey results on health-seeking behavior to convert that estimate to CFR among all infected persons (CFRAR). RESULTS: During the pandemic period, 5.0% (3.1%-6.9%) of 561 pH1N1-positive outpatients were hospitalized. Of 282 pH1N1-positive inpatients, 8.5% (5.7%-12.6%) died. CFRMA for pH1N1 was 0.4% (0.2%-0.6%) in the pandemic period 2009-2011 but declined 5-fold in young adults during the post-pandemic period compared to the level of seasonal influenza in the post-pandemic period 2012-2015. CFR for influenza-negative patients did not change over time. We estimated the 2009 pandemic CFRAR to be 0.025%, 16-fold lower than CFRMA. CONCLUSIONS: Data from a clinical research network yielded accurate pandemic severity estimates, including increased severity among younger people. Going forward, clinical research networks with a global presence and standardized protocols would substantially aid rapid assessment of clinical severity