Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis

Background: WHO identifies pregnant women to be at increased risk for severe outcomes from influenza virus infections and recommends that they be prioritized for influenza vaccination. The evidence supporting this, however, is inconsistent. Ecologic studies in particular suggest more severe outcomes from influenza infection during pregnancy than studies based on individual patient data. Individual studies however may be underpowered and, as reported in a previous systematic review, confounding factors could not be adjusted for. We therefore conducted an individual participant data meta-analysis to assess the risk for severe outcomes of influenza infection in pregnant women while adjusting for other prognostic factors. Methods: We contacted authors of studies included in a recently published systematic review. We pooled the individual participant data of women of reproductive age and laboratory confirmation of influenza virus infection. We used a generalized linear mixed model and reported odds ratios (OR) and 95% confidence intervals (CI). Results: A total of 33 datasets with data on 186,656 individuals were available, including 36,498 eligible women of reproductive age and known pregnancy status. In the multivariable model, pregnancy was associated with a 7 times higher risk of hospital admission (OR 6.80, 95%CI 6.02–7.68), among patients receiving medical care as in- or outpatients, pregnancy was associated with a lower risk of admission to intensive care units (ICU; OR 0.57, 95%CI 0.48–0.69), and was not significantly associated with death (OR 1.00, 95%CI 0.75–1.34). Conclusions: Our study found a higher risk of influenza associated hospitalization among pregnant women as compared to non-pregnant women. We did not find a higher mortality rate or higher likelihood of ICU admission among pregnant women who sought medical care. However, this study did not address whether a true community based cohort of pregnant women is at higher risk of influenza associated complications.Fil: Mertz, Dominik. Mc Master University; CanadáFil: Lo, Calvin Ka Fung. Mc Master University; CanadáFil: Lytvyn, Lyubov. Mc Master University; CanadáFil: Ortiz, Justin R.. Organizacion Mundial de la Salud; ArgentinaFil: Loeb, Mark. Mc Master University; CanadáFil: Ang, Li Wei. Ministry of Health; SingapurFil: Anlikumar, Mehta Asmita. Amrita Vishwa Vidyapeetham; IndiaFil: Bonmarin, Isabelle. Santé publique; FranciaFil: Borja Aburto, Victor Hugo. Instituto Mexicano del Seguro Social; MéxicoFil: Burgmann, Heinz. Medical University Vienna; AustriaFil: Carratalà, Jordi. Universidad de Barcelona; España. Instituto de Investigación Biomédica de Bellvitge; España. Spanish Network for Research in Infectious Diseases; EspañaFil: Chowell, Gerardo. Georgia State University; Estados Unidos. National Institutes of Health; Estados UnidosFil: Cilloniz, Catia. Universidad de Barcelona; España. Instituto de Investigaciones Biomédicas August Pi i Sunyer; EspañaFil: Cohen, Jessica. Centers for Disease Control and Prevention; Estados UnidosFil: Cutter, Jeffery. Ministry of Health; SingapurFil: Filleul, Laurent. Santé publique; Francia. French National Public Health Agency; FranciaFil: Garg, Shikha. Centers for Disease Control and Prevention; Estados UnidosFil: Geis, Steffen. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Helferty, Melissa. Public Health Agency; CanadáFil: Huang, Wan Ting. Taiwan Centers for Disease Control; ChinaFil: Jain, Seema. Centers for Disease Control and Prevention; Estados UnidosFil: Sevic, Biljana Joves. Institute for Pulmonary Diseases of Vojvodina; SerbiaFil: Kelly, Paul. Australian Capital Territory Health Directorate; Australia. Australian National University Medical School; AustraliaFil: Kusznierz, Gabriela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Respiratorias; ArgentinaFil: Lehners, Nicola. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Lenzi, Luana. Universidade Federal do Paraná; BrasilFil: Ling, Ivan T.. Sir Charles Gairdner Hospital; AustraliaFil: Mitchell, Robyn. Public Health Agency; CanadáFil: Mulrennan, Siobhain A.. Sir Charles Gairdner Hospital; Canadá. University of Western Australia; AustraliaFil: Nishioka, Sergio A.. Ministerio de Salud de Brasil; BrasilFil: Norton, Robert. Townsville Hospital; AustraliaFil: Oh, Won Sup. Kangwon National University School of Medicine; Corea del SurFil: Orellano, Pablo Wenceslao. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Integration of transient strain events with models of plate coupling and areas of great earthquakes in southwest Japan

We model the crustal deformation caused by two long-term subduction slip transients in southwest Japan, which we refer to as the 2000–2004 Tokai and the 2002–2004 Bungo Channel slow slip events (SSEs). We use re-analysed GEONET position time-series, and a Kalman filter based network inversion method to image the spatiotemporal slip variation of the two events on the plate interface during the period of 1998–2004.67 and 2000–2005. Both events are found to have complex slip histories with multiple subevents. In addition to a newly identified slip subevent in 2002–2003, we find that the major event in the Bungo Channel SSE initiated in early 2003 beneath the northeastern corner of the region and expanded southwestward, in contrast to the slip characteristics suggested by other studies. The re-analysed GPS data in the Tokai region shows a renewed slip activity for the Tokai SSE in early 2003–2004 at a similar location as in the period of 2001–2002. The equivalent M w for both the Tokai and Bungo Channel SSEs are about 7.0. Our results show that the Tokai SSE appears to start before the Miyaki-Kozu seismovolcanic event. Integrating plate coupling and SSEs shows that the transient slip zones are located in a region between the locked zones and the epicentres of the low frequency earthquakes (LFEs). At least part of the interseismic slip deficit is released by episodic SSEs beneath the Bungo Channel region. We find excellent temporal correspondence between transient slip and adjacent LFEs for both SSE, suggesting that they are closely related and possibly reflect that long-term slow slip may modulate the occurrence of LFEs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79234/1/j.1365-246X.2010.04599.x.pd

Fearing an Inhuman(e) Future: The Unliterary or Illiterate Dystopia of Aldous Huxley’s Brave New World

Though not necessarily recognized as a major canonical work of English literature, Aldous Huxley’s 1932 novel Brave New World is the paradigm of the modern social satire. The novel, a combination of dystopia, satire, science fiction and perhaps more, is set in the distant yet horrifyingly familiar future of A.F. 632 (Year of our Ford). In this time, Huxley depicts a supposed utopian world free of problems. Nevertheless, the novel also shows how this modern human society’s elimination of problems eliminates its humanity. My thesis specifically focuses on the elimination of humanity as manifested in the lack of literature and literacy throughout the novel. Huxley’s use of allusion and parody, almost Joycean, to other great literature of the past sets his novel apart from others like it and makes the work truly universal and lasting

The Adriatic region: An independent microplate within the Africa-Eurasia collision zone

We use GPS measurements and block modeling to investigate the present-day deformation of the Adriatic region, whose kinematics within the Nubia-Eurasia plate boundary zone is not well constrained and remains controversial. Block modeling allows us to compute rigid-plate angular velocities while accounting for elastic strain accumulation along block-bounding faults. Results suggest that the Adriatic is a microplate (Adria) and that the southern boundary with the Nubia plate and the Aegean domain may be located along the Apulia Escarpment and the Kefallinia fault. Geodetic data alone cannot discriminate between a single block (AP) or a two blocks (GDAP) description of Adria, but the GDAP model predicts boundary slip rates that are in better agreement with observations from previous studies. Copyright 2004 by the American Geophysical Union

Some practical suggestions for improving engagement between researchers and policy-makers in natural resource management

Policy-makers and managers in natural resource management (NRM) often complain that researchers are out of touch. Researchers often complain that policy-makers and managers make poorly informed decisions. In this article, we report on a meeting between researchers, policy-makers and managers convened to identify practical solutions to improve engagement between these camps. A necessary starting point is that every researcher and policy-maker should understand, and tap into, the motivations and reward systems of the other when seeking engagement. For example, researchers can be motivated to engage in policy development if there is a promise of outputs that align with their reward systems such as co-authored publications. Successful research-policy partnerships are built around personal relationships. As a researcher, you cannot therefore expect your results to inform policy by only publishing in journals. As a policy-maker, you cannot guarantee engagement from researchers by publicly inviting comment on a document. Actively building and maintaining relationships with key individuals through discussions, meetings, workshops or field days will increase the likelihood that research outcomes will inform policy decisions. We identified secondments, sabbaticals, fellowships and 'buddies', an annual national NRM conference and 'contact mapping' (a Facebook-type network) as forums that can catalyse new relationships between researchers and policy-makers. We challenge every researcher, policy-maker and manager in NRM to build one new cross-cultural relationship each year