The Improvement of Care in Patients with Pancreatic Cancer

Introduction: Pancreas adenocarcinoma (PDAC) remains a lethal malignancy with a high‐mortality rate and poor long‐term survival. The management of PDAC has evolved over the years to incorporate multidisciplinary care and numerous treatment modalities

Hepatocellular carcinoma survival in uninsured and underinsured patients.

BACKGROUND: The incidence of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) is increasing. The purpose of this study is to establish baseline survival in a medically-underserved population and to evaluate the effect of HCV seropositivity on our patient population. MATERIALS AND METHODS: We reviewed clinicopathologic parameters from a prospective tumor registry and medical records from the Harris County Hospital District (HCHD). Outcomes were compared using Kaplan-Meier survival analysis and log-rank tests. RESULTS: A total of 298 HCC patients were identified. The median survival for the entire cohort was 3.4 mo. There was no difference in survival between the HCV seropositive and the HCV seronegative groups (3.6 mo versus 2.6 mo, P = 0.7). Patients with a survival \u3c1 mo had a significant increase in\u3eαfetoprotein (AFP), international normalized ratio (INR), model for end-stage liver disease (MELD) score, and total bilirubin and decrease in albumin compared with patients with a survival ≥ 1 mo. CONCLUSIONS: Survival for HCC patients in the HCHD is extremely poor compared with an anticipated median survival of 7 mo reported in other studies. HCV seropositive patients have no survival advantage over HCV seronegative patients. Poorer liver function at diagnosis appears to be related to shorter survival. Further analysis into variables contributing to decreased survival is needed

Search for positively charged strangelets and other related results with E864 at the AGS

We report on the latest results in the search for positively charged strangelets from E864's 96/97 run at the AGS with sensitivity of about $8\times 10^{-9}$ per central collision. This contribution also contains new results of a search for highly charged strangelets with $Z=+3$. Production of light nuclei, such as $^6He$ and $^6Li$, is presented as well. Measurements of yields of these rarely produced isotopes near midrapidity will help constrain the production levels of strangelets via coalescence. E864 also measures antiproton production which includes decays from antihyperons. Comparisons with antiproton yields measured by E878 as a function of centrality indicate a large antihyperon-to-antiproton ratio in central collisions.Comment: 8 pages, 4 figures; Talk at SQM'98, Padova, Italy (July 20-24th, 1998

First Results from the ISO‐IRAS Faint Galaxy Survey

We present the first results from the ISO-IRAS Faint Galaxy Survey (IIFGS), a program designed to obtain ISO observations of the most distant and luminous galaxies in the IRAS Faint Source Survey by filling short gaps in the ISO observing schedule with pairs of 12 μm ISOCAM and 90 μm ISOPHOT observations. As of 1997 October, over 500 sources have been observed, with an ISOCAM detection rate over 80%, covering over 1.25 deg^2 of sky to an 11.5 μm point-source completeness limit of approximately 1.0 mJy (corresponding to a ~10 σ detection sensitivity). Observations are presented for nine sources detected by ISOPHOT and ISOCAM early in the survey for which we have ground-based G- and I-band images and optical spectroscopy. The ground-based data confirm that the IIFGS strategy efficiently detects moderate-redshift (z = 0.11-0.38 for this small sample) strong emission line galaxies with L_(60 μm) ≳ 10^(11) L_☉; one of our sample has L_(60 μm) > 10^(12) L_☉ (H_0 = 75 km s^(-1) Mpc^(-1), Ω = 1). The infrared-optical spectral energy distributions are comparable to those of nearby luminous infrared galaxies, which span the range from pure starburst (e.g., Arp 220) to infrared QSO (Mrk 231). Two of the systems show signs of strong interaction, and four show active galactic nucleus (AGN)-like excitation; one of the AGNs, F15390+6038, which shows a high excitation Seyfert 2 spectrum, has an unusually warm far- to mid-infrared color and may be an obscured QSO. The IIFGS sample is one of the largest and deepest samples of infrared-luminous galaxies available, promising to be a rich sample for studying infrared-luminous galaxies up to z ~ 1 and for understanding the evolution of infrared galaxies and the star formation rate in the universe

Antideuteron yield at the AGS and coalescence implications

We present Experiment 864's measurement of invariant antideuteron yields in 11.5A GeV/c Au + Pt collisions. The analysis includes 250 million triggers representing 14 billion 10% central interactions sampled for events with high mass candidates. We find (1/2 pi pt) d^(2)N/dydpt = 3.5 +/- 1.5 (stat.) +0.9,-0.5 (sys.) x 10^(-8) GeV^(-2)c^(2) for 1.8=0.35 GeV/c (y(cm)=1.6) and 3.7 +/- 2.7 (stat.) +1.4,-1.5 (sys.) x 10^(-8) GeV^(-2)c^(2) for 1.4=0.26 GeV/c, and a coalescence parameter B2-bar of 4.1 +/- 2.9 (stat.) +2.3,-2.4 (sys.) x 10^(-3) GeV^(2)c^(-3). Implications for the coalescence model and antimatter annihilation are discussed.Comment: 8 pages, 4 figures, Latex, submitted to Phys. Rev. Let

The ISO-IRAS Faint Galaxy Survey

The ISO-IRAS Faint Galaxy Survey will obtain comprehensive space- and ground-based observations of the most distant and luminous galaxies in the IRAS Faint Source Survey. ISO observations are obtained by filling short gaps in the ISO observing schedule with pairs of 11.5μm ISOCAM and 90μm ISOPHOT observations. As of the October 1997 date of this Conference, over 500 sources have been observed by ISO with an ISOCAM detection rate exceeding 803. Ground-based spectrophotometry confirms that the IIFGS efficiently detects moderateredshift, strong emission line Luminous Infrared Galaxies. Spectrophotometry is currently available for 67 galaxies with 0.07 < z < 0. 7 and L_(fir) > 10^(11) L_☉. The galaxies are comparable to nearby LIGs, showing HII/Liner excitation; about 10% exhibit strong AGN characteristics. As a part of this survey we will cover over 1.25 square degrees of sky to an 11.5μm limit of approximately l.0mJy, allowing a sensitive estimate of the 11.5μm logN-logS Relationship. Preliminary ll.5μm source counts suggest substantial evolution in the mid-infrared galaxy population

Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation

The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and compared to 44 distal bile duct and 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in the WNT signaling pathway among half of the patients and in all three adenocarcinomas irrespective of their origin and histological morphology. These tumors were characterized by a high frequency of inactivating mutations of ELF3, a high rate of microsatellite instability, and common focal deletions and amplifications, suggesting common attributes in the molecular pathogenesis are at play in these tumors. The high frequency of WNT pathway activating mutation, coupled with small-molecule inhibitors of β-catenin in clinical trials, suggests future treatment decisions for these patients may be guided by genomic analysis

Mass dependence of light nucleus production in ultrarelativistic heavy ion collisions

Light nuclei can be produced in the central reaction zone via coalescence in relativistic heavy ion collisions. E864 at BNL has measured the production of ten light nuclei with nuclear number of A=1 to A=7 at rapidity $y\simeq1.9$ and $p_{T}/A\leq300MeV/c$. Data were taken with a Au beam of momentum of 11.5 A $GeV/c$ on a Pb or Pt target with different experimental settings. The invariant yields show a striking exponential dependence on nuclear number with a penalty factor of about 50 per additional nucleon. Detailed analysis reveals that the production may depend on the spin factor of the nucleus and the nuclear binding energy as well.Comment: (6 pages, 3 figures), some changes on text, references and figures' lettering. To be published in PRL (13Dec1999

Antiproton Production in 11.5 A GeV/c Au+Pb Nucleus-Nucleus Collisions

We present the first results from the E864 collaboration on the production of antiprotons in 10% central 11.5 A GeV/c Au+Pb nucleus collisions at the Brookhaven AGS. We report invariant multiplicities for antiproton production in the kinematic region 1.4<y<2.2 and 50<p_T<300 MeV/c, and compare our data with a first collision scaling model and previously published results from the E878 collaboration. The differences between the E864 and E878 antiproton measurements and the implications for antihyperon production are discussed.Comment: 4 pages, 4 figures; accepted for publication in Physical Review Letter

Measurements of Light Nuclei Production in 11.5 A GeV/c Au+Pb Heavy-Ion Collisions

We report on measurements by the E864 experiment at the BNL-AGS of the yields of light nuclei in collisions of Au(197) with beam momentum of 11.5 A GeV/c on targets of Pb(208) and Pt(197). The yields are reported for nuclei with baryon number A=1 up to A=7, and typically cover a rapidity range from y(cm) to y(cm)+1 and a transverse momentum range of approximately 0.1 < p(T)/A < 0.5 GeV/c. We calculate coalescence scale factors B(A) from which we extract model dependent source dimensions and collective flow velocities. We also examine the dependences of the yields on baryon number, spin, and isospin of the produced nuclei.Comment: 21 figures-to be published in Phys. Rev.