Survivability of copper projectiles during hypervelocity impacts in porous ice: A laboratory investigation of the survivability of projectiles impacting comets or other bodies

AbstractDuring hypervelocity impact (>a few kms−1) the resulting cratering and/or disruption of the target body often outweighs interest on the outcome of the projectile material, with the majority of projectiles assumed to be vaporised. However, on Earth, fragments, often metallic, have been recovered from impact sites, meaning that metallic projectile fragments may survive a hypervelocity impact and still exist within the wall, floor and/or ejecta of the impact crater post-impact. The discovery of the remnant impactor composition within the craters of asteroids, planets and comets could provide further information regarding the impact history of a body. Accordingly, we study in the laboratory the survivability of 1 and 2mm diameter copper projectiles fired onto ice at speeds between 1.00 and 7.05kms−1. The projectile was recovered intact at speeds up to 1.50kms−1, with no ductile deformation, but some surface pitting was observed. At 2.39kms−1, the projectile showed increasing ductile deformation and broke into two parts. Above velocities of 2.60kms−1 increasing numbers of projectile fragments were identified post impact, with the mean size of the fragments decreasing with increasing impact velocity. The decrease in size also corresponds with an increase in the number of projectile fragments recovered, as with increasing shock pressure the projectile material is more intensely disrupted, producing smaller and more numerous fragments. The damage to the projectile is divided into four classes with increasing speed and shock pressure: (1) minimal damage, (2) ductile deformation, start of break up, (3) increasing fragmentation, and (4) complete fragmentation. The implications of such behaviour is considered for specific examples of impacts of metallic impactors onto Solar System bodies, including LCROSS impacting the Moon, iron meteorites onto Mars and NASA’s “Deep Impact” mission where a spacecraft impacted a comet

LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete. Here, we describe a population of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-expressing TAMs, which form coordinated multi-cellular “nest” structures that are heterogeneously distributed proximal to vasculature in tumors of a spontaneous murine model of breast cancer. We demonstrate that LYVE-1+ TAMs develop in response to IL-6, which induces their expression of the immune-suppressive enzyme heme oxygenase-1 and promotes a CCR5-dependent signaling axis, which guides their nest formation. Blocking the development of LYVE-1+ TAMs or their nest structures, using gene-targeted mice, results in an increase in CD8+ T cell recruitment to the tumor and enhanced response to chemotherapy. This study highlights an unappreciated collaboration of a TAM subset to form a coordinated niche linked to immune exclusion and resistance to anti-cancer therapy

Assessing the survivability of biomarkers within terrestrial material impacting the lunar surface

The history of organic and biological markers (biomarkers) on the Earth is effectively non-existent in the geological record >3.8 Ga ago. Here, we investigate the potential for terrestrial material (i.e., terrestrial meteorites) to be transferred to the Moon by a large impact on Earth and subsequently survive impact with the lunar surface, using the iSALE shock physics code. Three-dimensional impact simulations show that a typical basin-forming impact on Earth can eject solid fragments equivalent to ~10–3 of an impactor mass at speeds sufficient to transfer from Earth to the Moon. Previous modelling of meteorite survivability has relied heavily upon the assumption that peak-shock pressures can be used as a proxy for gauging survival of projectiles and their possible biomarker constituents. Here, we show the importance of considering both pressure and temperature within the projectile, and the inclusion of both shock and shear heating, in assessing biomarker survival. Assuming that they survive launch from Earth, we show that some biomarker molecules within terrestrial meteorites are likely to survive impact with the Moon, especially at the lower end of the range of typical impact velocities for terrestrial meteorites (2.5 km s-1). The survival of larger biomarkers (e.g., microfossils) is also assessed, and we find limited, but significant, survival for low impact velocity and high target porosity scenarios. Thermal degradation of biomarkers shortly after impact depends heavily upon where the projectile material lands, whether it is buried or remains on the surface, and the related cooling timescales. Comparing sandstone and limestone projectiles shows similar temperature and pressure profiles for the same impact velocities, with limestone providing slightly more favourable conditions for biomarker survival

LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete. Here, we describe a population of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-expressing TAMs, which form coordinated multi-cellular "nest" structures that are heterogeneously distributed proximal to vasculature in tumors of a spontaneous murine model of breast cancer. We demonstrate that LYVE-1 + TAMs develop in response to IL-6, which induces their expression of the immune-suppressive enzyme heme oxygenase-1 and promotes a CCR5-dependent signaling axis, which guides their nest formation. Blocking the development of LYVE-1 + TAMs or their nest structures, using gene-targeted mice, results in an increase in CD8 + T cell recruitment to the tumor and enhanced response to chemotherapy. This study highlights an unappreciated collaboration of a TAM subset to form a coordinated niche linked to immune exclusion and resistance to anti-cancer therapy

Tumour-associated carbohydrate antigens in breast cancer

Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed

The Winchcombe meteorite, a unique and pristine witness from the outer solar system.

Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing further evidence that volatile-rich carbonaceous asteroids played an important role in the origin of Earth's water

The Winchcombe meteorite—A regolith breccia from a rubble pile CM chondrite asteroid

The Winchcombe meteorite is a CM chondrite breccia composed of eight distinct lithological units plus a cataclastic matrix. The degree of aqueous alteration varies between intensely altered CM2.0 and moderately altered CM2.6. Although no lithology dominates, three heavily altered rock types (CM2.1–2.3) represent >70 area%. Tochilinite–cronstedtite intergrowths (TCIs) are common in several lithologies. Their compositions can vary significantly, even within a single lithology, which can prevent a clear assessment of alteration extent if only TCI composition is considered. We suggest that this is due to early alteration under localized geochemical microenvironments creating a diversity of compositions and because later reprocessing was incomplete, leaving a record of the parent body's fluid history. In Winchcombe, the fragments of primary accretionary rock are held within a cataclastic matrix (~15 area%). This material is impact‐derived fallback debris. Its grain size and texture suggest that the disruption of the original parent asteroid responded by intergranular fracture at grain sizes <100 μm, while larger phases, such as whole chondrules, splintered apart. Re‐accretion formed a poorly lithified body. During atmospheric entry, the Winchcombe meteoroid broke apart with new fractures preferentially cutting through the weaker cataclastic matrix and separating the breccia into its component clasts. The strength of the cataclastic matrix imparts a control on the survival of CM chondrite meteoroids. Winchcombe's unweathered state and diversity of lithologies make it an ideal sample for exploring the geological history of the CM chondrite group

The Winchcombe meteorite—A regolith breccia from a rubble pile CM chondrite asteroid

The Winchcombe meteorite is a CM chondrite breccia composed of eight distinct lithological units plus a cataclastic matrix. The degree of aqueous alteration varies between intensely altered CM2.0 and moderately altered CM2.6. Although no lithology dominates, three heavily altered rock types (CM2.1–2.3) represent >70 area%. Tochilinite–cronstedtite intergrowths (TCIs) are common in several lithologies. Their compositions can vary significantly, even within a single lithology, which can prevent a clear assessment of alteration extent if only TCI composition is considered. We suggest that this is due to early alteration under localized geochemical microenvironments creating a diversity of compositions and because later reprocessing was incomplete, leaving a record of the parent body's fluid history. In Winchcombe, the fragments of primary accretionary rock are held within a cataclastic matrix (~15 area%). This material is impact‐derived fallback debris. Its grain size and texture suggest that the disruption of the original parent asteroid responded by intergranular fracture at grain sizes <100 μm, while larger phases, such as whole chondrules, splintered apart. Re‐accretion formed a poorly lithified body. During atmospheric entry, the Winchcombe meteoroid broke apart with new fractures preferentially cutting through the weaker cataclastic matrix and separating the breccia into its component clasts. The strength of the cataclastic matrix imparts a control on the survival of CM chondrite meteoroids. Winchcombe's unweathered state and diversity of lithologies make it an ideal sample for exploring the geological history of the CM chondrite group