Glass Ceiling Commission - The Glass Ceiling in Different Sectors of the Economy: Differences Between Government, Non-profit, and For-profit Organizations

Glass Ceiling ReportGlassCeilingBackground3SectorsEconomy.pdf: 2169 downloads, before Oct. 1, 2020

Meaning and Impact of Board and Staff Diversity in the Philanthropic Field: Findings from a National Study

The report's premise is that the staffs and boards of philanthropic institutions have not kept pace with the general population in terms of diversity, and that if responsiveness and diversity are linked, then foundations must attend to their internal diversity if they wish to offer a more credible outreach to diverse communities. It seeks to find answers to the following questions: What is the empirical reality that grounds these conjectures? Can we quantify the changes in foundation staffing? How well represented are different identity groups within the field, and how do members of these diverse groups fare in their career advancement? How do different types of foundations address inclusiveness, and what are examples of practices that lead to successful implementation of staff and board diversity? The report is the result of a multi-stage research project that combined surveys, interviews, and focus groups to reach more than 600 grantmakers nationwide

Evidence for an Intense Neutrino Flux during rr-Process Nucleosynthesis?

We investigate the possibility that neutrino capture on heavy nuclei competes with beta decay in the environment where the $r$-Process elements are synthesized. We find that such neutrino capture is not excluded by existing abundance determinations. We show that inclusion of significant neutrino capture on the (neutron number) N=82 waiting point nuclei can allow the inferred abundances of these species to provide a good fit to steady weak (beta decay plus neutrino capture) flow equilibrium. In fact, for particular choices of neutrino flux conditions, this fit is improved over the case where nuclei change their charge by beta decay alone. However, this improved fit can be realized only if neutrino capture plays a negligible role in nuclear decay back toward stability. We discuss the implications of these considerations for current proposed sites and models for $r$-Process nucleosynthesis.Comment: 10 pages, plain tex, submitted to ApJ

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands

The synaptic α1β2γ2 GAB

QSRlib: a software library for online acquisition of qualitative spatial relations from video

There is increasing interest in using Qualitative Spatial Relations as a formalism to abstract from noisy and large amounts of video data in order to form high level conceptualisations, e.g. of activities present in video. We present a library to support such work. It is compatible with the Robot Operating System (ROS) but can also be used stand alone. A number of QSRs are built in; others can be easily added

A blind spot? Confronting the stigma of hepatitis B virus (HBV) infection - A systematic review

Background: Stigma, poverty, and lack of knowledge present barriers to the diagnosis and treatment of chronic infection, especially in resource-limited settings. Chronic Hepatitis B virus (HBV) infection is frequently asymptomatic, but accounts for a substantial long-term burden of morbidity and mortality. In order to improve the success of diagnostic, treatment and preventive strategies, it is important to recognise, investigate and tackle stigma. We set out to assimilate evidence for the nature and impact of stigma associated with HBV infection, and to suggest ways to tackle this challenge. Methods: We carried out a literature search in PubMed using the search terms ‘hepatitis B’, ‘stigma’ to identify relevant papers published between 2007 and 2017 (inclusive), with a particular focus on Africa. Results: We identified a total of 32 articles, of which only two studies were conducted in Africa. Lack of knowledge of HBV was consistently identified, and in some settings there was no local word to describe HBV infection. There were misconceptions about HBV infection, transmission and treatment. Healthcare workers provided inaccurate information to individuals diagnosed with HBV, and poor understanding resulted in lack of preventive measures. Stigma negatively impacted on help-seeking, screening, disclosure, prevention of transmission, and adherence to treatment, and had potential negative impacts on mental health, wellbeing, employment and relationships. Conclusion: Stigma is a potentially major barrier to the successful implementation of preventive, diagnostic and treatment strategies for HBV infection, and yet we highlight a ‘blind spot’, representing a lack of data and limited recognition of this challenge. There is a need for more research in this area, to identify and evaluate interventions that can be used effectively to tackle stigma, and to inform collaborative efforts between patients, clinical services, policy makers, traditional healers, religious leaders, charity organisations and support groups.</ns4:p

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in induction and patterning of the ventral forebrain. Currently little is known about how Shh is regulated in prechordal tissue. Here we show that in the embryonic chick, Shh is expressed transiently in prechordal mesoderm, and is governed by unprocessed Nodal. Exposure of prechordal mesoderm microcultures to Nodal-conditioned medium, the Nodal inhibitor CerS, or to an ALK4/5/7 inhibitor reveals that Nodal is required to maintain both Shh and Gsc expression, but whereas Gsc is largely maintained through canonical signalling, Nodal signals through a non-canonical route to maintain Shh. Further, Shh expression can be maintained by a recombinant Nodal cleavage mutant, proNodal, but not by purified mature Nodal. A number of lines of evidence suggest that proNodal acts via FGFR3. ProNodal and FGFR3 co-immunoprecipitate and proNodal increases FGFR3 tyrosine phosphorylation. In microcultures, soluble FGFR3 abolishes Shh without affecting Gsc expression. Further, prechordal mesoderm cells in which Fgfr3 expression is reduced by Fgfr3 siRNA fail to bind to proNodal. Finally, targeted electroporation of Fgfr3 siRNA to prechordal mesoderm in vivo results in premature Shh downregulation without affecting Gsc. We report an inverse correlation between proNodal-FGFR3 signalling and pSmad1/5/8, and show that proNodal-FGFR3 signalling antagonises BMP-mediated pSmad1/5/8 signalling, which is poised to downregulate Shh. Our studies suggest that proNodal/FGFR3 signalling governs Shh duration by repressing canonical BMP signalling, and that local BMPs rapidly silence Shh once endogenous Nodal-FGFR3 signalling is downregulated

Estimating the nuclear level density with the Monte Carlo shell model

A method for making realistic estimates of the density of levels in even-even nuclei is presented making use of the Monte Carlo shell model (MCSM). The procedure follows three basic steps: (1) computation of the thermal energy with the MCSM, (2) evaluation of the partition function by integrating the thermal energy, and (3) evaluating the level density by performing the inverse Laplace transform of the partition function using Maximum Entropy reconstruction techniques. It is found that results obtained with schematic interactions, which do not have a sign problem in the MCSM, compare well with realistic shell-model interactions provided an important isospin dependence is accounted for.Comment: 14 pages, 3 postscript figures. Latex with RevTex. Submitted as a rapid communication to Phys. Rev.