Modeling highly pathogenic avian influenza transmission in wild birds and poultry in West Bengal, India.

Wild birds are suspected to have played a role in highly pathogenic avian influenza (HPAI) H5N1 outbreaks in West Bengal. Cluster analysis showed that H5N1 was introduced in West Bengal at least 3 times between 2008 and 2010. We simulated the introduction of H5N1 by wild birds and their contact with poultry through a stochastic continuous-time mathematical model. Results showed that reducing contact between wild birds and domestic poultry, and increasing the culling rate of infected domestic poultry communities will reduce the probability of outbreaks. Poultry communities that shared habitat with wild birds or those indistricts with previous outbreaks were more likely to suffer an outbreak. These results indicate that wild birds can introduce HPAI to domestic poultry and that limiting their contact at shared habitats together with swift culling of infected domestic poultry can greatly reduce the likelihood of HPAI outbreaks

The Kinematic Origin of the Cosmological Redshift

A common belief about big-bang cosmology is that the cosmological redshift cannot be properly viewed as a Doppler shift (that is, as evidence for a recession velocity), but must be viewed in terms of the stretching of space. We argue that, contrary to this view, the most natural interpretation of the redshift is as a Doppler shift, or rather as the accumulation of many infinitesimal Doppler shifts. The stretching-of-space interpretation obscures a central idea of relativity, namely that it is always valid to choose a coordinate system that is locally Minkowskian. We show that an observed frequency shift in any spacetime can be interpreted either as a kinematic (Doppler) shift or a gravitational shift by imagining a suitable family of observers along the photon\u27s path. In the context of the expanding universe the kinematic interpretation corresponds to a family of comoving observers and hence is more natural

Does Gener Impact the Immune Response of Chicks?

Sequencing technology allows us tosee how the gene expression of each genechanges under different treatment conditions. In this study, chicks of two inbred lines were challenged with Newcastle Disease Virus (NDV), a pathogen with devastating impacts on poultry throughout the world. At each of the three time points post-infection, one-third of the chicks were sacraficed and their lungs were harvested. When comparing males and females infected with NDV, differences in gene expression that were predicted to impact growth and apoptosis were identified. Differences between the response of males and females to viral challenges could be useful information for production operations. The interaction between production traits and immune related traits require further study

Impact of community based peer support in type 2 diabetes: a cluster randomised controlled trial of individual and/or group approaches

Background: Diabetes peer support, where one person with diabetes helps guide and support others, has been proposed as a way to improve diabetes management. We have tested whether different diabetes peer support strategies can improve metabolic and/or psychological outcomes.<p></p> Methods: People with type 2 diabetes (n=1,299) were invited to participate as either ‘peer’ or ‘peer support facilitator’ (PSF) in a 2x2 factorial pragmatic randomised cluster controlled trial across rural communities (130 clusters) in England. Peer support was delivered over 8-12 months by trained PSFs, supported by monthly meetings with a diabetes educator. Primary end point was HbA1c. Secondary outcomes included quality of life, diabetes distress, blood pressure, waist, total cholesterol and weight. Outcome assessors and investigators were masked to arm allocation. Main factors were 1:1 or group intervention. Analysis was by intention-to-treat adjusting for baseline.<p></p> Results: The 4 arms were well matched (Group n=330, 1:1 n=325, combined n=322, control n=322); 1035 (79·7%) completed the mid-point postal questionnaire and 1064 (81·9%) had a final HbA1c. A limitation was that although 92.6% PSFs and peers were in telephone contact, only 61.4% of intervention participants attended a face to face session.<p></p> Mean baseline HbA1c was 57 mmol/mol (7·4%), with no significant change across arms. Systolic blood pressure was reduced by -2·3mm Hg (-4·0 to -0·6) among those allocated group peer-support and -3·0mm Hg (-5·0 to -1·1) among those who attended group peer-support at least once. There was no impact on other outcomes by intention to treat or significant differences between arms in self-reported adherence or medication.<p></p> Conclusions: Group diabetes peer support over 8-12 months was associated with a small improvement in blood pressure but no other benefits. Long term benefits should be investigated

A Minimal Congruence Lattice Representation for ₚ₊₁

Let p be an odd prime. The unary algebra consisting of the dihedral group of order 2p, acting on itself by left translation, is a minimal congruence lattice representation of p+1

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.

Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota NDV strain at 21 days of age. Through transcriptome analysis, gene expression in spleen at 2 and 6 days post-inoculation was compared between NDV-infected and control groups, as well as between chicken lines. At a false discovery rate <0.05, Fayoumi chickens, which are relatively more resistant to NDV, showed fewer differentially expressed genes (DEGs) than Leghorn chickens. Several interferon-stimulated genes were identified as important DEGs regulating immune response to NDV in chicken. Pathways predicted by IPA analysis, such as "EIF-signaling", "actin cytoskeleton organization nitric oxide production" and "coagulation system" may contribute to resistance to NDV in Fayoumi chickens. The identified DEGs and predicted pathways may contribute to differential responses to NDV between the two chicken lines and provide potential targets for breeding chickens that are more resistant to NDV

Shear Power Spectrum Reconstruction using Pseudo-Spectrum Method

We develop a pseudo power spectrum technique for measuring the lensing power spectrum from weak lensing surveys in both the full sky and flat sky limits. The power spectrum approaches have a number of advantages over the traditional correlation function approach. We test the pseudo spectrum method by using numerical simulations with square-shape boundary that include masked regions with complex configuration due to bright stars and saturated spikes. Even when 25% of total area of the survey is masked, the method recovers the E-mode power spectrum at a sub-percent precision over a wide range of multipoles 100<l<10000. The systematic error is smaller than the statistical errors expected for a 2000 square degree survey. The residual B-mode spectrum is well suppressed in the amplitudes at less than a percent level relative to the E-mode. We also find that the correlated errors of binned power spectra caused by the survey geometry effects are not significant. Our method is applicable to the current and upcoming wide-field lensing surveys.Comment: 11 pages, 4 figures, accepted for publication in MNRA