Nonuniform high-gamma (60-500 Hz) power changes dissociate cognitive task and anatomy in human cortex

High-gamma-band (\u3e60 Hz) power changes in cortical electrophysiology are a reliable indicator of focal, event-related cortical activity. Despite discoveries of oscillatory subthreshold and synchronous suprathreshold activity at the cellular level, there is an increasingly popular view that high-gamma-band amplitude changes recorded from cellular ensembles are the result of asynchronous firing activity that yields wideband and uniform power increases. Others have demonstrated independence of power changes in the low- and high-gamma bands, but to date, no studies have shown evidence of any such independence above 60 Hz. Based on nonuniformities in time-frequency analyses of electrocorticographic (ECoG) signals, we hypothesized that induced high-gamma-band (60-500 Hz) power changes are more heterogeneous than currently understood. Using single-word repetition tasks in six human subjects, we showed that functional responsiveness of different ECoG high-gamma sub-bands can discriminate cognitive task (e.g., hearing, reading, speaking) and cortical locations. Power changes in these sub-bands of the high-gamma range are consistently present within single trials and have statistically different time courses within the trial structure. Moreover, when consolidated across all subjects within three task-relevant anatomic regions (sensorimotor, Broca\u27s area, and superior temporal gyrus), these behavior- and location-dependent power changes evidenced nonuniform trends across the population. Together, the independence and nonuniformity of power changes across a broad range of frequencies suggest that a new approach to evaluating high-gamma-band cortical activity is necessary. These findings show that in addition to time and location, frequency is another fundamental dimension of high-gamma dynamics

Extremely Red Objects in the Field of QSO 1213-0017: A Galaxy Concentration at z=1.31

We have discovered a concentration of extremely red objects (EROs; R-K>6) in the field of the z=2.69 quasar QSO 1213-0017 (UM 485), which is significantly overabundant compared to the field ERO surface density. The optical/near-IR colors of the EROs and numerous other red galaxies in this field are consistent with elliptical galaxies at z=1-2. HST optical images for a subset of galaxies show regular morphologies, most of them being disky or diffuse and without any obvious evidence for interactions. Ground-based IR images show similar morphologies, indicating any dust reddening in these objects is spatially uniform. Optical spectroscopy with the W. M. Keck Telescope has found that four of the red galaxies lie at =1.31, and a fifth lies in the foreground at z=1.20. Of the =1.31 galaxies, one is a reddened AGN while the remaining three have rest-frame UV absorption-line spectra characteristic of old (few Gyr) stellar populations, similar to the old red galaxy LBDS 53W091 at z=1.55. Including the MgII absorber seen in the QSO spectrum, we find five galaxies at =1.31 spread over 1.5 h_50^{-1} Mpc on the sky. These results suggest we have discovered a coherent structure of old galaxies at high-redshift, possibly associated with a massive galaxy cluster.Comment: 37 pages including 11 Postscript figures. To appear in the June 2000 issue of the Astronomical Journa

A Methodology for Characterizing Gun Barrel Flexure due to Vehicle Motion [J

Barrel centerline curvature is known to influence the location of projectile shot impacts. Superimposed on the unique manufactured barrel centerline is the flexed barrel shape that can occur prior to firing while the vehicle is on the move. In order to understand and quantify the effects of barrel flexure on gun accuracy, it is necessary to determine what combination of fundamental mode shapes is most likely to occur. A method to accomplish this task is described in this paper. The method is demonstrated by enumerating the 10 most likely flexed barrel shapes that were found to occur in a tank-mounted gun barrel while it traversed a bump course

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming

BACKGROUND: Although chronic morbidity in humans from soil transmitted helminth (STH) infections can be reduced by anthelmintic treatment, inconsistent diagnostic tools make it difficult to reliably measure the impact of deworming programs and often miss light helminth infections. METHODS: Cryopreserved stool samples from 796 people (aged 2-81 years) in four villages in Bungoma County, western Kenya, were assessed using multi-parallel qPCR for 8 parasites and compared to point-of-contact assessments of the same stools by the 2-stool 2-slide Kato-Katz (KK) method. All subjects were treated with albendazole and all Ascaris lumbricoides expelled post-treatment were collected. Three months later, samples from 633 of these people were re-assessed by both qPCR and KK, re-treated with albendazole and the expelled worms collected. RESULTS: Baseline prevalence by qPCR (n = 796) was 17 % for A. lumbricoides, 18 % for Necator americanus, 41 % for Giardia lamblia and 15% for Entamoeba histolytica. The prevalence was <1% for Trichuris trichiura, Ancylostoma duodenale, Strongyloides stercoralis and Cryptosporidium parvum. The sensitivity of qPCR was 98% for A. lumbricoides and N. americanus, whereas KK sensitivity was 70% and 32%, respectively. Furthermore, qPCR detected infections with T. trichiura and S. stercoralis that were missed by KK, and infections with G. lamblia and E. histolytica that cannot be detected by KK. Infection intensities measured by qPCR and by KK were correlated for A. lumbricoides (r = 0.83, p < 0.0001) and N. americanus (r = 0.55, p < 0.0001). The number of A. lumbricoides worms expelled was correlated (p < 0.0001) with both the KK (r = 0.63) and qPCR intensity measurements (r = 0.60). CONCLUSIONS: KK may be an inadequate tool for stool-based surveillance in areas where hookworm or Strongyloides are common or where intensity of helminth infection is low after repeated rounds of chemotherapy. Because deworming programs need to distinguish between populations where parasitic infection is controlled and those where further treatment is required, multi-parallel qPCR (or similar high throughput molecular diagnostics) may provide new and important diagnostic information

Stellar Populations of UV-Selected Active Galactic Nuclei Host Galaxies at z ~ 2 - 3

We use stellar population synthesis modeling to analyze the host galaxy properties of a sample of 33 UV-selected, narrow-lined active galactic nuclei (AGNs) at z ~ 2 - 3. In order to quantify the contribution of AGN emission to host galaxy broadband spectral energy distributions (SEDs), we use the subsample of 11 AGNs with photometric coverage spanning from rest-frame UV through near-IR wavelengths. Modeling the SEDs of these objects with a linear combination of stellar population and AGN templates, we infer the effect of the AGN on derived stellar population parameters. We also estimate the typical bias in derived stellar populations for AGNs lacking rest-frame near-IR wavelength coverage, and develop a method for inferring the true host galaxy properties. We compare AGN host galaxy properties to those of a sample of UV-selected, star-forming non-AGNs in the same redshift range, including a subsample carefully matched in stellar mass. Although the AGNs have higher masses and SFRs than the full non-active sample, their stellar population properties are consistent with those of the mass-selected sample, suggesting that the presence of an AGN is not connected with the cessation of star-formation activity in star-forming galaxies at z ~ 2 - 3. We suggest that a correlation between M_BH and galaxy stellar mass is already in place at this epoch. Assuming a roughly constant Eddington ratio for AGNs at all stellar masses, we are unable to detect the AGNs in low-mass galaxies because they are simply too faint.Comment: 30 pages, 16 figures, ApJ accepted. Replaced with accepted versio

Sustaining Progress towards NTD Elimination: An Opportunity to Leverage Lymphatic Filariasis Elimination Programs to Interrupt Transmission of Soil-Transmitted Helminths

Copyright © 2016 Means et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

A mobile health + health coaching application for the management of chronic non-cancer pain in older adults: Results from a pilot randomized controlled study

IntroductionThe rapid growth of mobile health (mHealth) devices holds substantial potential for improving care and care outcomes in aging adults with chronic non-cancer pain (CNCP), however, research evaluating these devices in older adults remains limited.ObjectiveTo ascertain the feasibility and preliminary efficacy of an mHealth intervention (Mymee) that combines symptom, diet, and behavior tracking via a smartphone application with data analytics to detect associations between symptoms and lifestyle factors along with weekly health coaching sessions to mitigate CNCP in adults 55 years of age and older.MethodsParticipants (N = 31) in this pilot study were recruited from one primary care practice in New York City and randomized to an intervention [app + up to 12 health coaching sessions (scheduled approximately once weekly) + usual care] or a control (app + usual care) arm. Feasibility measures included recruitment (proportion of eligible persons who enrolled) and retention rates (proportion of subjects completing a follow-up assessment) as well as adherence with the weekly coaching sessions and logging daily data on the app. Efficacy outcomes (e.g., pain intensity, self-efficacy, disability, anxiety) were assessed at baseline and follow-up (~16 weeks after baseline). Descriptive statistics were obtained and general linear mixed models used for primary analyses.ResultsParticipants had a mean (standard deviation) age of 67.32 (9.17) and were mostly female (61%). Feasibility outcomes were mixed as evidenced by recruitment and retention rates of 74% and 65%, respectively. The mean number of weekly coaching sessions attended by intervention participants was 6.05 (SD = 5.35), while the average number of days logging data on the app was 44.82 (34.02). We found a consistent trend in favor of the intervention, where pain intensity, affect, and quality of life measures improved considerably more among intervention (vs. control) participants. Finally, the proportion of participants with GAD-7 scores at follow up decreased by 0.35 to 0, whereas controls did not change, a significant effect in favor of the intervention (p = 0.02).ConclusionsThis study supports the need for future research that seeks to enhance feasibility outcomes and confirm the efficacy of the Mymee intervention among aging adults with CNCP