174 research outputs found
Gamma-band synchronization in the macaque hippocampus and memory formation
Increasing evidence suggests that neuronal synchronization in the gamma band (30–100 Hz) may play an important role in mediating cognitive processes. Gamma-band synchronization provides for the optimal temporal relationship between two signals to produce the long-term synaptic changes that have been theorized to underlie memory formation. Although neuronal populations in the hippocampus oscillate in the gamma range, the role of these oscillations in memory formation is still unclear. To address this issue, we recorded neuronal activity in the hippocampus while macaque monkeys performed a visual recognition memory task. During the encoding phase of this task, hippocampal neurons displayed gamma-band synchronization. Additionally, enhanced gamma-band synchronization during encoding predicted greater subsequent recognition memory performance. These changes in synchronization reflect enhanced coordination among hippocampal neurons and may facilitate synaptic changes necessary for successful memory encoding
Short-Term Memory Trace in Rapidly Adapting Synapses of Inferior Temporal Cortex
Visual short-term memory tasks depend upon both the inferior temporal cortex (ITC) and the prefrontal cortex (PFC). Activity in some neurons persists after the first (sample) stimulus is shown. This delay-period activity has been proposed as an important mechanism for working memory. In ITC neurons, intervening (nonmatching) stimuli wipe out the delay-period activity; hence, the role of ITC in memory must depend upon a different mechanism. Here, we look for a possible mechanism by contrasting memory effects in two architectonically different parts of ITC: area TE and the perirhinal cortex. We found that a large proportion (80%) of stimulus-selective neurons in area TE of macaque ITCs exhibit a memory effect during the stimulus interval. During a sequential delayed matching-to-sample task (DMS), the noise in the neuronal response to the test image was correlated with the noise in the neuronal response to the sample image. Neurons in perirhinal cortex did not show this correlation. These results led us to hypothesize that area TE contributes to short-term memory by acting as a matched filter. When the sample image appears, each TE neuron captures a static copy of its inputs by rapidly adjusting its synaptic weights to match the strength of their individual inputs. Input signals from subsequent images are multiplied by those synaptic weights, thereby computing a measure of the correlation between the past and present inputs. The total activity in area TE is sufficient to quantify the similarity between the two images. This matched filter theory provides an explanation of what is remembered, where the trace is stored, and how comparison is done across time, all without requiring delay period activity. Simulations of a matched filter model match the experimental results, suggesting that area TE neurons store a synaptic memory trace during short-term visual memory
The relationship between self-awareness of attentional status, behavioral performance and oscillatory brain rhythms
High-level cognitive factors, including self-awareness, are believed to play an important role in human visual perception. The principal aim of this study was to determine whether oscillatory brain rhythms play a role in the neural processes involved in self-monitoring attentional status. To do so we measured cortical activity using magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) while participants were asked to self-monitor their internal status, only initiating the presentation of a stimulus when they perceived their attentional focus to be maximal. We employed a hierarchical Bayesian method that uses fMRI results as soft-constrained spatial information to solve the MEG inverse problem, allowing us to estimate cortical currents in the order of millimeters and milliseconds. Our results show that, during self-monitoring of internal status, there was a sustained decrease in power within the 7-13 Hz (alpha) range in the rostral cingulate motor area (rCMA) on the human medial wall, beginning approximately 430 msec after the trial start (p < 0.05, FDR corrected). We also show that gamma-band power (41-47 Hz) within this area was positively correlated with task performance from 40-640 msec after the trial start (r = 0.71, p < 0.05). We conclude: (1) the rCMA is involved in processes governing self-monitoring of internal status; and (2) the qualitative differences between alpha and gamma activity are reflective of their different roles in self-monitoring internal states. We suggest that alpha suppression may reflect a strengthening of top-down interareal connections, while a positive correlation between gamma activity and task performance indicates that gamma may play an important role in guiding visuomotor behavior. © 2013 Yamagishi et al
Spontaneous Local Gamma Oscillation Selectively Enhances Neural Network Responsiveness
Synchronized oscillation is very commonly observed in many neuronal systems and
might play an important role in the response properties of the system. We have
studied how the spontaneous oscillatory activity affects the responsiveness of a
neuronal network, using a neural network model of the visual cortex built from
Hodgkin-Huxley type excitatory (E-) and inhibitory (I-) neurons. When the
isotropic local E-I and I-E synaptic connections were sufficiently strong, the
network commonly generated gamma frequency oscillatory firing patterns in
response to random feed-forward (FF) input spikes. This spontaneous oscillatory
network activity injects a periodic local current that could amplify a weak
synaptic input and enhance the network's responsiveness. When E-E
connections were added, we found that the strength of oscillation can be
modulated by varying the FF input strength without any changes in single neuron
properties or interneuron connectivity. The response modulation is proportional
to the oscillation strength, which leads to self-regulation such that the
cortical network selectively amplifies various FF inputs according to its
strength, without requiring any adaptation mechanism. We show that this
selective cortical amplification is controlled by E-E cell interactions. We also
found that this response amplification is spatially localized, which suggests
that the responsiveness modulation may also be spatially selective. This
suggests a generalized mechanism by which neural oscillatory activity can
enhance the selectivity of a neural network to FF inputs
Transcriptome Profiling of Citrus Fruit Response to Huanglongbing Disease
Huanglongbing (HLB) or “citrus greening” is the most destructive citrus disease worldwide. In this work, we studied host responses of citrus to infection with Candidatus Liberibacter asiaticus (CaLas) using next-generation sequencing technologies. A deep mRNA profile was obtained from peel of healthy and HLB-affected fruit. It was followed by pathway and protein-protein network analysis and quantitative real time PCR analysis of highly regulated genes. We identified differentially regulated pathways and constructed networks that provide a deep insight into the metabolism of affected fruit. Data mining revealed that HLB enhanced transcription of genes involved in the light reactions of photosynthesis and in ATP synthesis. Activation of protein degradation and misfolding processes were observed at the transcriptomic level. Transcripts for heat shock proteins were down-regulated at all disease stages, resulting in further protein misfolding. HLB strongly affected pathways involved in source-sink communication, including sucrose and starch metabolism and hormone synthesis and signaling. Transcription of several genes involved in the synthesis and signal transduction of cytokinins and gibberellins was repressed while that of genes involved in ethylene pathways was induced. CaLas infection triggered a response via both the salicylic acid and jasmonic acid pathways and increased the transcript abundance of several members of the WRKY family of transcription factors. Findings focused on the fruit provide valuable insight to understanding the mechanisms of the HLB-induced fruit disorder and eventually developing methods based on small molecule applications to mitigate its devastating effects on fruit production
Dynamic Effective Connectivity of Inter-Areal Brain Circuits
Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity (or, more precisely, causal connectivity), related to the elusive question “Which areas cause the present activity of which others?”. Effective connectivity is directed and depends flexibly on contexts and tasks. Here we show that dynamic effective connectivity can emerge from transitions in the collective organization of coherent neural activity. Integrating simulation and semi-analytic approaches, we study mesoscale network motifs of interacting cortical areas, modeled as large random networks of spiking neurons or as simple rate units. Through a causal analysis of time-series of model neural activity, we show that different dynamical states generated by a same structural connectivity motif correspond to distinct effective connectivity motifs. Such effective motifs can display a dominant directionality, due to spontaneous symmetry breaking and effective entrainment between local brain rhythms, although all connections in the considered structural motifs are reciprocal. We show then that transitions between effective connectivity configurations (like, for instance, reversal in the direction of inter-areal interactions) can be triggered reliably by brief perturbation inputs, properly timed with respect to an ongoing local oscillation, without the need for plastic synaptic changes. Finally, we analyze how the information encoded in spiking patterns of a local neuronal population is propagated across a fixed structural connectivity motif, demonstrating that changes in the active effective connectivity regulate both the efficiency and the directionality of information transfer. Previous studies stressed the role played by coherent oscillations in establishing efficient communication between distant areas. Going beyond these early proposals, we advance here that dynamic interactions between brain rhythms provide as well the basis for the self-organized control of this “communication-through-coherence”, making thus possible a fast “on-demand” reconfiguration of global information routing modalities
Police-initiated diversion for youth to prevent future delinquent behavior: a systematic review
BackgroundOverly punitive responses to youth misconduct may have the unintended consequence ofincreasing the likelihood of future delinquency; yet, overly lenient responses may fail to serveas a corrective for the misbehavior. Police diversion schemes are a collection of strategiespolice can apply as an alternative to court processing of youth. Police-initiated diversionschemes aim to reduce reoffending by steering youth away from deeper penetration into thecriminal justice system and by providing an alternative intervention that can help youthaddress psychosocial development or other needs that contribute to their problem behavior.ObjectivesThe objective of this review was to synthesize the evidence on the effectiveness of pre-courtinterventions involving police warning or counseling and release, and cautioning schemes inreducing delinquent behavior.Search methodsA combination of 26 databases and websites were searched. References of relevant reviewswere also scanned to identify studies. We also consulted with experts in the field. Searcheswere executed by two reviewers and conducted between August 2016 and January 2017.Selection criteriaOnly experimental and quasi-experimental designs were eligible for this review. All quasiexperimentaldesigns must have had a comparison group similar to the police diversionintervention group with respect to demographic characteristics and prior involvement indelinquent behavior (i.e., at similar risk for future delinquent behavior). Additionally, studiesmust have included youth participants between 12 and 17 years of age who either underwenttraditional system processing or were diverted from court processing through a police-leddiversion program. Studies were also eligible if delinquency-related outcomes, includingofficial and non-official (self-report or third-party reporting) measures of delinquency werereported.Data collection and analysisThis study used meta-analysis to synthesize results across studies. This method involvedsystematic coding of study features and conversion of study findings into effect sizesreflecting the direction and magnitude of any police-led diversion effect. There were 19independent evaluations across the 14 primary documents coded for this review. From this,we coded 67 effect sizes of delinquent behavior post diversion across 31 diversion-traditionalprocessing comparisons. We analyzed these comparisons using two approaches. The firstapproach selected a single effect size per comparison based on a decision rule and the secondused all 67 effect sizes, nesting these within comparison condition and evaluation design.ResultsThe general pattern of evidence is positive, suggesting that police-led diversion modestlyreduces future delinquent behavior of low-risk youth relative to traditional processing.Authors’ conclusionsThe findings from this systematic review support the use of police-led diversion for low-riskyouth with limited or no prior involvement with the juvenile justice system. Thus, policedepartments and policy-makers should consider diversionary programs as part of the mix ofsolutions for addressing youth crime
The effects of problem-oriented policing on crime and disorder
Problem-oriented Policing (POP) was first introduced by Herman Goldstein in 1979. The
approach was one of a series of responses to a crisis in effectiveness and legitimacy in
policing that emerged in the 1970s and 1980s. Goldstein argued that police were not
being effective in preventing and controlling crime because they had become too focused
on the “means” of policing and had neglected the “goals” of preventing and controlling
crime and other community problems. Goldstein argued that the unit of analysis in
policing must become the “problem” rather than calls or crime incidents as was the case
during that period. POP has had tremendous impact on American policing, and is now
one of the most widely implemented policing strategies in the US.
To synthesize the extant problem-oriented policing evaluation literature and assess the
effects of problem-oriented policing on crime and disorder
Eligible studies had to meet three criteria: (1) the SARA model was used for a problemoriented
policing intervention; (2) a comparison group was included; (3) at least one
crime or disorder outcome was reported with sufficient data to generate an effect size.
The unit of analysis could be people or places.
Several strategies were used to perform an exhaustive search for literature fitting the
eligibility criteria. First, a keyword search was performed on an array of online abstract
databases. Second, we reviewed the bibliographies of past reviews of problem-oriented
policing. Third, we performed forward searches for works that have cited seminal
problem-oriented policing studies. Fourth, we performed hand searches of leading
journals in the field. Fifth, we searched the publications of several research and
professional agencies. Sixth, after finishing the above searches we e-mailed the list of
studies meeting our eligibility criteria to leading policing scholars knowledgeable in the
area of problem-oriented policing to ensure we had not missed any relevant studies.
For our ten eligible studies, we provide both a narrative review of effectiveness and a
meta-analysis. For the meta-analysis, we coded all primary outcomes of the eligible
studies and we report the mean effect size (for studies with more than one primary
outcome, we averaged effects to create a mean), the largest effect, and the smallest effect.
Because of the heterogeneity of our studies, we used a random effects model.
Based on our meta-analysis, overall problem-oriented policing has a modest but
statistically significant impact on reducing crime and disorder. Our results are consistent
when examining both experimental and quasi-experimental studies.
Conclusions:
We conclude that problem-oriented policing is effective in reducing crime and disorder,
although the effect is fairly modest. We urge caution in interpreting these results because
of the small number of methodologically rigorous studies on POP and the diversity of
problems and responses used in our eligible studies
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