6,340 research outputs found
A dual-mode generalized likelihood ratio approach to self-reorganizing digital flight control system design
The research is reported on the problems of failure detection and reliable system design for digital aircraft control systems. Failure modes, cross detection probability, wrong time detection, application of performance tools, and the GLR computer package are discussed
First test of a high voltage feedthrough for liquid Argon TPCs connected to a 300 kV power supply
Voltages above a hundred kilo-volt will be required to generate the drift
field of future very large liquid Argon Time Projection Chambers. The most
delicate component is the feedthrough whose role is to safely deliver the very
high voltage to the cathode through the thick insulating walls of the cryostat
without compromising the purity of the argon inside. This requires a
feedthrough that is typically meters long and carefully designed to be vacuum
tight and have small heat input. Furthermore, all materials should be carefully
chosen to allow operation in cryogenic conditions. In addition, electric fields
in liquid argon should be kept below a threshold to reduce risks of discharges.
The combination of all above requirements represents significant challenges
from the design and manufacturing perspective. In this paper, we report on the
successful operation of a feedthrough satisfying all the above requirements.
The details of the feedthrough design and its manufacturing steps are provided.
Very high voltages up to unprecedented voltages of -300 kV could be applied
during long periods repeatedly. A source of instability was observed, which was
specific to the setup configuration which was used for the test and not due to
the feedthrough itself.Comment: 13 pages, 9 figure
Small Molecule Drug Discovery at the Glucagon-Like Peptide-1 Receptor
The therapeutic success of peptide glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes mellitus has inspired discovery efforts aimed at developing orally available small molecule GLP-1 receptor agonists. Although the GLP-1 receptor is a member of the structurally complex class B1 family of GPCRs, in recent years, a diverse array of orthosteric and allosteric nonpeptide ligands has been reported. These compounds include antagonists, agonists, and positive allosteric modulators with intrinsic efficacy. In this paper, a comprehensive review of currently disclosed small molecule GLP-1 receptor ligands is presented. In addition, examples of “ligand bias” and “probe dependency” for the GLP-1 receptor are discussed; these emerging concepts may influence further optimization of known molecules or persuade designs of expanded screening strategies to identify novel chemical starting points for GLP-1 receptor drug discovery
Measurement, model testing, and legislative influence in the European Union
Within the last several years, new data have become available to test the various theoretical models of EU decision-making, and, in doing so, to assess actor influence. This article examines the extent to which the recent DEU and DEUII datasets provide sufficient information to distinguish between competing theoretical models of legislative decision-making, and accurately assess the power of the different branches of EU government. It argues that insufficient attention has been paid to measurement error in these data. Once measurement error is accounted for, it becomes clear that these data do not provide sufficient information to distinguish between most models of legislative politics. Moreover, empirical models that fail to account for measurement error are likely to lead researchers to erroneous conclusions about actors’ legislative influence. </jats:p
Underground Neutrino Detectors for Particle and Astroparticle Science: the Giant Liquid Argon Charge Imaging ExpeRiment (GLACIER)
The current focus of the CERN program is the Large Hadron Collider (LHC),
however, CERN is engaged in long baseline neutrino physics with the CNGS
project and supports T2K as recognized CERN RE13, and for good reasons: a
number of observed phenomena in high-energy physics and cosmology lack their
resolution within the Standard Model of particle physics; these puzzles include
the origin of neutrino masses, CP-violation in the leptonic sector, and baryon
asymmetry of the Universe. They will only partially be addressed at LHC. A
positive measurement of would certainly give a
tremendous boost to neutrino physics by opening the possibility to study CP
violation in the lepton sector and the determination of the neutrino mass
hierarchy with upgraded conventional super-beams. These experiments (so called
``Phase II'') require, in addition to an upgraded beam power, next generation
very massive neutrino detectors with excellent energy resolution and high
detection efficiency in a wide neutrino energy range, to cover 1st and 2nd
oscillation maxima, and excellent particle identification and
background suppression. Two generations of large water Cherenkov
detectors at Kamioka (Kamiokande and Super-Kamiokande) have been extremely
successful. And there are good reasons to consider a third generation water
Cherenkov detector with an order of magnitude larger mass than Super-Kamiokande
for both non-accelerator (proton decay, supernovae, ...) and accelerator-based
physics. On the other hand, a very massive underground liquid Argon detector of
about 100 kton could represent a credible alternative for the precision
measurements of ``Phase II'' and aim at significantly new results in neutrino
astroparticle and non-accelerator-based particle physics (e.g. proton decay).Comment: 31 pages, 14 figure
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