Contrast-Induced Nephropathy: Nephrologist's Opinion:

Contrast-induced nephropathy (CIN) has become the third leading cause of hospital-acquired acute kidney injury (AKI), due to an increasing number of patients receiving intravascular injection of io..

3D-modelling of the stellar auroral radio emission

The electron cyclotron maser is the coherent emission process that gives rise to the radio lighthouse effect observed in the hot magnetic chemically peculiar star CU Virginis. It has also been proposed to explain the highly circularly polarized radio pulses observed on some ultra cool dwarfs, with spectral type earlier than M7. Such kind of coherent events resemble the auroral radio emission from the magnetized planets of the solar system. In this paper, we present a tridimensional model able to simulate the timing and profile of the pulses emitted by those stars characterized by a dipolar magnetic field by following the hypothesis of the laminar source model, used to explain the beaming of the terrestrial auroral kilometric radiation. This model proves to be a powerful tool to understand the auroral radio-emission phenomenon, allowing us to derive some general conclusions about the effects of the model's free parameters on the features of the coherent pulses, and to learn more about the detectability of such kind of pulsed radio emission.Comment: 11 pages, 8 figures; accepted for publication in MNRA

Searching for OH maser emission towards the MIPSGAL compact Galactic bubbles

We conducted radio observations searching for OH 18-cm maser emission from a sample of 169 unclassified MIPSGAL compact Galactic bubbles. These sources are thought to be the circumstellar envelopes of different kinds of evolved stars. Our observations were aimed at shedding light on the nature of MIPSGAL bubbles, since their characterisation is a fundamental aid for the development of accurate physical models of stellar and Galaxy evolution. The maser emission is observatively linked to the last stages of the life of low- and intermediate-mass stars, which may constitute a significant fraction of the MIPSGAL bubbles. In particular OH masers are usually observed towards post-AGB stars. Our observations were performed with the Green Bank Telescope and, for each source, produced spectra around the four OH 18-cm transitions. The observations were compared with archive interferometer data in order to exclude possible contamination from nearby sources. The main result is that the OH maser emission is not a common feature among the MIPSGAL bubbles, with only one certain detection. We conclude that among the MIPSGAL bubbles the post-AGB stars could be very rare

Expanded Very Large Array Observations of the Nebula Around G79.29+0.46

We have observed the radio nebula surrounding the Galactic luminous blue variable candidate G79.29+0.46 with the Expanded Very Large Array (EVLA) at 6 cm. These new radio observations allow a morphological comparison between the radio emission, which traces the ionized gas component, and the mid-IR emission, a tracer of the dust component. The InfraRed Array Camera (8 μm) and the Multiband Imaging Photometer for Spitzer (24 μm and 70 μm) images have been reprocessed and compared with the EVLA map. We confirm the presence of a second shell at 24 μm and also provide evidence for its detection at 70 μm. The differences between the spatial morphology of the radio and mid-IR maps indicate the existence of two dust populations, the cooler one emitting mostly at longer wavelengths. Analysis of the two dusty, nested shells have provided us with an estimate of the characteristic timescales for shell ejection, providing important constraints for stellar evolutionary models. Finer details of the ionized gas distribution can be appreciated thanks to the improved quality of the new 6 cm image, most notably the highly structured texture of the nebula. Evidence of interaction between the nebula and the surrounding interstellar medium can be seen in the radio map, including brighter features that delineate regions where the shell structure is locally modified. In particular, the brighter filaments in the southwest region appear to frame the shocked southwestern clump reported from CO observations

Automated detection of extended sources in radio maps: progress from the SCORPIO survey

Automated source extraction and parameterization represents a crucial challenge for the next-generation radio interferometer surveys, such as those performed with the Square Kilometre Array (SKA) and its precursors. In this paper we present a new algorithm, dubbed CAESAR (Compact And Extended Source Automated Recognition), to detect and parametrize extended sources in radio interferometric maps. It is based on a pre-filtering stage, allowing image denoising, compact source suppression and enhancement of diffuse emission, followed by an adaptive superpixel clustering stage for final source segmentation. A parameterization stage provides source flux information and a wide range of morphology estimators for post-processing analysis. We developed CAESAR in a modular software library, including also different methods for local background estimation and image filtering, along with alternative algorithms for both compact and diffuse source extraction. The method was applied to real radio continuum data collected at the Australian Telescope Compact Array (ATCA) within the SCORPIO project, a pathfinder of the ASKAP-EMU survey. The source reconstruction capabilities were studied over different test fields in the presence of compact sources, imaging artefacts and diffuse emission from the Galactic plane and compared with existing algorithms. When compared to a human-driven analysis, the designed algorithm was found capable of detecting known target sources and regions of diffuse emission, outperforming alternative approaches over the considered fields.Comment: 15 pages, 9 figure

Nefropatia da mezzodi contrasto: il parere del Nefrologo

La nefropatia da contrasto (CIN) rappresenta oggi la terza causa di insufficienza renale acuta (AKI) in pazienti ospedalizzati, condizione da ricondurre a un incremento dei pazienti che si sottopongono a procedure radiologiche interventistiche richiedenti la somministrazione intravascolare di mezzi di contrasto iodati (ICM). Bisogna inoltre considerare un incremento di soggetti con fattori di rischio quali l'età avanzata, una preesistente patologia renale, scompenso cardiaco, infarto del miocardio, diabete mellito. Si considera CIN la presenza di un incremento assoluto (= 0.5mg/dL) e relativo (= 25%), rispetto ai valori basali, della creatinina sierica (sCreat) a 48–72 ore dall'esposizione dell'ICM. È noto però come in pazienti con variazioni acute del filtrato glomerulare (GFR), sCreat è un marker dotato di poca sensibilità e specificità diagnostica. Infatti, il 25–50% dell'incremento della creatinina, con alto valore predittivo di CIN, si verifica più frequentemente solo 24 ore dopo la somministrazione dell'ICM. Negli ultimi anni, sono stati condotti studi non solo al fine di identificare nuovi biomarcatori, ma anche per valutare eventuali strategie terapeutiche preventive. La somministrazione endovenosa di soluzione salina allo 0.9% è ampiamente accettata come terapia profilattica di CIN. Diversi sono inoltre gli studi condotti che prevedono la somministrazione di bicarbonato di sodio o di N-acetilcisteina (NAC). Purtroppo molti studi mancano di potenza statistica o sono basati su diverse definizioni di CIN. Ciò ha determinato la mancanza di linee guida universali accettate dai radiologi, nefrologi, cardiologi o da altre figure professionali coinvolte. Sono quindi necessari ulteriori studi al fine di validare i risultati sino ad ora ottenuti, specie utilizzando marcatori dotati di maggiore potere diagnostico e prognostico rispetto alla creatinina sierica, quali NGAL, Cistatina C e KIM-1

New ATCA, ALMA and VISIR observations of the candidate LBV SK-67266 (S61): the nebular mass from modelling 3D density distributions

We present new observations of the nebula around the Magellanic candidate Luminous Blue Variable S61. These comprise high-resolution data acquired with the Australia Telescope Compact Array (ATCA), the Atacama Large Millimetre/Submillimetre Array (ALMA), and VISIR at the Very Large Telescope (VLT). The nebula was detected only in the radio, up to 17 GHz. The 17 GHz ATCA map, with 0.8 arcsec resolution, allowed a morphological comparison with the H$\alpha$ Hubble Space Telescope image. The radio nebula resembles a spherical shell, as in the optical. The spectral index map indicates that the radio emission is due to free-free transitions in the ionised, optically thin gas, but there are hints of inhomogeneities. We present our new public code RHOCUBE to model 3D density distributions, and determine via Bayesian inference the nebula's geometric parameters. We applied the code to model the electron density distribution in the S61 nebula. We found that different distributions fit the data, but all of them converge to the same ionised mass, ~0.1 $\rm M\odot$, which is an order of magnitude smaller than previous estimates. We show how the nebula models can be used to derive the mass-loss history with high-temporal resolution. The nebula was probably formed through stellar winds, rather than eruptions. From the ALMA and VISIR non-detections, plus the derived extinction map, we deduce that the infrared emission observed by space telescopes must arise from extended, diffuse dust within the ionised region.Comment: 17 pages, 9 figures. Authors list corrected. In press in MNRAS. RHOCUBE code available online ( https://github.com/rnikutta/rhocube

Exploring the multifaceted circumstellar environment of the luminous blue variable HR Carinae

Indexación: Web of Science; Scopus.We present a multiwavelength study of the Galactic luminous blue variable HR Carinae, based on new high-resolution mid-infrared (IR) and radio images obtained with the Very Large Telescope (VLT) and the Australia Telescope Compact Array (ATCA), which have been complemented by far-infrared Herschel-Photodetector Array Camera and Spectrometer (PACS) observations and ATCA archive data. The Herschel images reveal the large-scale distribution of the dusty emitting nebula, which extends mainly to the north-east direction, up to 70 arcsec from the central star, and is oriented along the direction of the space motion of the star. In the mid-infrared images, the brightness distribution is characterized by two arcshaped structures, tracing an inner envelope surrounding the central star more closely. At radio wavelengths, the ionized gas emission lies on the opposite side of the cold dust with respect to the position of the star, as if the ionized front were confined by the surrounding medium in the north-south direction. Comparison with previous data indicates significant changes in the radio nebula morphology and in the mass-loss rate from the central star, which has increased from 6.1 × 10-6M⊙ yr-1 in 1994-1995 to 1.17 × 10-5M⊙ yr-1 in 2014. We investigate possible scenarios that could have generated the complex circumstellar environment revealed by our multiwavelength data.https://academic.oup.com/mnras/article-lookup/doi/10.1093/mnras/stw307

Neuroprotection by erythropoietin administration after experimental traumatic brain injury.

A large body of evidence indicates that the hormone erythropoietin (EPO) exerts beneficial effects in the central nervous system (CNS). To date, EPO's effect has been assessed in several experimental models of brain and spinal cord injury. This study was conducted to validate whether treatment with recombinant human EPO (rHuEPO) would limit the extent of injury following experimental TBI. Experimental TBI was induced in rats by a cryogenic injury model. rHuEPO or placebo was injected intraperitoneally immediately after the injury and then every 8 h until 2 or 14 days. Forty-eight hours after injury brain water content, an indicator of brain edema, was measured with the wet-dry method and blood-brain barrier (BBB) breakdown was evaluated by assay of Evans blue extravasation. Furthermore, extent of cerebral damage was assessed. Administration of rHuEPO markedly improved recovery from motor dysfunction compared with placebo group (P < 0.05). Brain edema was significantly reduced in the cortex of the EPO-treated group relative to that in the placebo-treated group (80.6 \ub1 0.3% versus 91.8% \ub1 0.8% respectively, P < 0.05). BBB breakdown was significantly lower in EPO-treated group than in the placebo-treated group (66.2 \ub1 18.7 \u3bcg/g versus 181.3 \ub1 21 \u3bcg/g, respectively, P < 0.05). EPO treatment reduced injury volume significantly compared with placebo group (17.4 \ub1 5.4 mm3 versus 37.1 \ub1 5.3 mm3, P < 0.05). EPO, administered in its recombinant form, affords significant neuroprotection in experimental TBI model and may hold promise for future clinical applications. \ua9 2007 Elsevier B.V. All rights reserved