Determination of unacceptable HLA antigen mismatches in kidney transplant recipients

With the introduction of the virtual allocation crossmatch in the Eurotransplant (ET) region in 2023, the determination of unacceptable antigen mismatches (UAM) in kidney transplant recipients is of utmost importance for histocompatibility laboratories and transplant centers. Therefore, a joined working group of members from the German Society for Immunogenetics (Deutsche Gesellschaft fur Immungenetik, DGI) and the German Transplantation Society (Deutsche Transplantationsgesellschaft, DTG) revised and updated the previous recommendations from 2015 in light of recently published evidence. Like in the previous version, a wide range of topics is covered from technical issues to clinical risk factors. This review summarizes the evidence about the prognostic value of contemporary methods for HLA antibody detection and identification, as well as the impact of UAM on waiting time, on which these recommendations are based. As no clear criteria could be determined to differentiate potentially harmful from harmless HLA antibodies, the general recommendation is to assign all HLA against which plausible antibodies are found as UAM. There is, however, a need for individualized solutions for highly immunized patients. These revised recommendations provide a list of aspects that need to be considered when assigning UAM to enable a fair and comprehensible procedure and to harmonize risk stratification prior to kidney transplantation between transplant centers

The Banff 2022 Kidney Meeting Work Plan:Data-driven refinement of the Banff Classification for renal allografts

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell–mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.</p

The Banff 2022 Kidney Meeting Work Plan:Data-driven refinement of the Banff Classification for renal allografts

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell–mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.</p

“Mother’s Day”

Mit kurzen Geschichten, Photos, Bildern und Gedichten versuchen die Autorinnen eine Annäherung an ihre Mütter zwischen den Jahren 1938 und 1958. Es geht ihnen darum, eine Frauengeneration die „Ehre“ zukommen zu lassen, die ihr in den Augen der Autorinnen – den Töchtern – zukommt. Wenig ‚redselig‘, wie die meisten waren, wenn es um sie selbst ging, müssen ihre Töchter zum Teil sehr mühsam Informationen zusammentragen. Es entsteht ein zum Teil sehr berührendes Panorama von starken und weniger starken Frauen, deren Positionierung zum politischen Kontext ihrer Zeit jedoch vielfach erstaunlich unklar bleibt.The authors attempt to illustrate the lives of their own mothers between the years 1938 and 1958 utilizing short stories, photos, pictures, and poetry. The authors wish to give “honor” to a generation of women that they—the daughters—believe the women deserve. As most of the women were not very “talkative” when it came to their lives, the daughters are forced to compile information, often with much difficulty. Because of this an often very moving panorama of strong and less strong women emerges, however whose position within the political context of the time oft remains surprisingly opaque

Musik in Bürgerhäusern

Das Bürgertum des 19. Jahrhunderts war eine Wertegemeinschaft. Dieser Befund gehört zu den Kemergebnissen der seit gut einem Jahrzehnt blühenden Bürgertumsforschung, die angesichts der breit gefächerten Berufsstruktur und einer daraus resultierenden äuẞerst divergierenden materiellen Situation dieser sozialen Formation ihre Aufmerksamkeit auf der Suche nach Kern und Klammer verstärkt auf die « bürgerliche Kultur » gelenkt hat. Bei alien wirtschaftlichen und politischen Diskrepanzen öffnete si..