The association of handgrip strength and mortality: What does it tell us and what can we do with it?

© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. If true, grip strength is not necessarily informing us of the importance of resistance exercise as an adult, but potentially highlighting inherent differences between individuals who are stronger at baseline compared to their weaker counterpart. The purpose of this article is to discuss: (1) potential factors that may influence grip strength and (2) hypothesize strategies that may be able to influence grip strength and ultimately attain a higher baseline level of strength. Although there appears to be a limited ability to augment grip strength as an adult, there may be critical periods during growth/development during which individuals can establish a higher baseline. Establishing a high baseline of strength earlier in life may have long-term implications related to mortality and disease

Cardiovascular and Muscular Response to NO LOAD Exercise with Blood Flow Restriction

International Journal of Exercise Science 13(2): 1807-1818, 2020. Changes in muscle thickness (MT), isometric torque, and arterial occlusion pressure (AOP) were examined following four sets of twenty unilateral elbow flexion exercise. Participants performed four sets of maximal voluntary contractions with no external load throughout a full range of motion of a bicep curl with and without the application of blood flow restriction (BFR). For torque there was an interaction (p = 0.012). The BFR condition had lower torque following exercise (56.07 ± 17.78 Nm) compared to the control condition (58.67 ± 19.06 Nm). For MT, there was a main effect for time (p \u3c 0.001). MT increased from pre (3.52 ± .78cm) to post (3.68 ± 81cm) exercise and remained increased above baseline 15 min post-exercise. For AOP, there was an interaction (p = 0.027). The change in AOP was greater in the BFR condition (16.6 ± 13.42mmHg) compared to the control (11.1 ± 11.84 mmHg). NO LOAD exercise with BFR let to greater reductions in torque and an exaggerated cardiovascular response compared to exercise alone. There were no differences in swelling. These results suggest that the application of BFR to NO LOAD exercise may result in greater fatigue

Limb Occlusion Pressure: A Method to Assess Changes in Systolic Blood Pressure

Although often used as a surrogate, comparisons between traditional blood pressure measurements and limb occlusion assessed via hand-held Doppler have yet to be completed. Using limb occlusion pressure as a method of assessing systolic pressure is of interest to those studying the acute effects of blood flow restriction, where the removal of the cuff may alter the physiological response. Purpose: We sought to determine how changes in limb occlusion pressure track with changes in traditional assessments of blood pressure. Basic Procedures: Limb occlusion pressure measured by hand-held Doppler and blood pressure measured by an automatic blood pressure cuff were assessed at rest and following isometric knee extension (post and 5 minutes post). Main Findings: Each individual had a similar dispersion from the mean value for both the limb occlusion pressure measurement and traditional systolic blood pressure measurement [BF10: 0.33; median (95% credible interval): 0.02 (−6.0, 5.9) %]. In response to lower body isometric exercise, blood pressure changed across time. The difference between measurements was small at immediately post and 5 minutes post. The Bayes factors were in the direction of the null but did not exceed the threshold needed to accept the null hypothesis. However, at 5 minutes post, the differences were within the range of practical equivalence (within ± 4.6%). Principal Conclusions: Our findings suggest that changes in limb occlusion pressure measured by hand-held Doppler track similarly to traditional measurements of brachial systolic blood pressure following isometric knee extension exercise

The Basics of Training for Muscle Size and Strength: A Brief Review on the Theory

The periodization of resistance exercise is often touted as the most effective strategy for optimizing muscle size and strength adaptations. This narrative persists despite a lack of experimental evidence to demonstrate its superiority. In addition, the general adaptation syndrome, which provides the theoretical framework underlying periodization, does not appear to provide a strong physiological rationale that periodization is necessary. Hans Selye conducted a series of rodent studies which used toxic stressors to facilitate the development of the general adaptation syndrome. To our knowledge, normal exercise in humans has never been shown to produce a general adaptation syndrome. We question whether there is any physiological rationale that a periodized training approach would facilitate greater adaptations compared with nonperiodized approaches employing progressive overload. The purpose of this article is to briefly review currently debated topics within strength and conditioning and provide some practical insight regarding the implications these reevaluations of the literature may have for resistance exercise and periodization. In addition, we provide some suggestions for the continued advancement within the field of strength and conditioning

Individual Responses for Muscle Activation, Repetitions, and Volume during Three Sets to Failure of High- (80% 1RM) \u3ci\u3eversus\u3c/i\u3e Low-Load (30% 1RM) Forearm Flexion Resistance Exercise

This study compared electromyographic (EMG) amplitude, the number of repetitions completed, and exercise volume during three sets to failure of high- (80% 1RM) versus low-load (30% 1RM) forearm flexion resistance exercise on a subject-by-subject basis. Fifteen men were familiarized, completed forearm flexion 1RM testing. Forty-eight to 72 h later, the subjects completed three sets to failure of dumbbell forearm flexion resistance exercise with 80% (n = 8) or 30% (n = 7) 1RM. EMG amplitude was calculated for every repetition, and the number of repetitions performed and exercise volume were recorded. During sets 1, 2, and 3, one of eight subjects in the 80% 1RM group demonstrated a significant linear relationship for EMG amplitude versus repetition. For the 30% 1RM group, seven, five, and four of seven subjects demonstrated significant linear relationships during sets 1, 2, and 3, respectively. The mean EMG amplitude responses show that the fatigue-induced increases in EMG amplitude for the 30% 1RM group and no change in EMG amplitude for the 80% 1RM group resulted in similar levels of muscle activation in both groups. The numbers of repetitions completed were comparatively greater, while exercise volumes were similar in the 30% versus 80% 1RM group. Our results, in conjunction with those of previous studies in the leg extensors, suggest that there may be muscle specific differences in the responses to high- versus low-load exercise

Individual Responses for Muscle Activation, Repetitions, and Volume during Three Sets to Failure of High- (80% 1RM) \u3cem\u3eversus\u3c/em\u3e Low-Load (30% 1RM) Forearm Flexion Resistance Exercise

This study compared electromyographic (EMG) amplitude, the number of repetitions completed, and exercise volume during three sets to failure of high- (80% 1RM) versus low-load (30% 1RM) forearm flexion resistance exercise on a subject-by-subject basis. Fifteen men were familiarized, completed forearm flexion 1RM testing. Forty-eight to 72 h later, the subjects completed three sets to failure of dumbbell forearm flexion resistance exercise with 80% (n = 8) or 30% (n = 7) 1RM. EMG amplitude was calculated for every repetition, and the number of repetitions performed and exercise volume were recorded. During sets 1, 2, and 3, one of eight subjects in the 80% 1RM group demonstrated a significant linear relationship for EMG amplitude versus repetition. For the 30% 1RM group, seven, five, and four of seven subjects demonstrated significant linear relationships during sets 1, 2, and 3, respectively. The mean EMG amplitude responses show that the fatigue-induced increases in EMG amplitude for the 30% 1RM group and no change in EMG amplitude for the 80% 1RM group resulted in similar levels of muscle activation in both groups. The numbers of repetitions completed were comparatively greater, while exercise volumes were similar in the 30% versus 80% 1RM group. Our results, in conjunction with those of previous studies in the leg extensors, suggest that there may be muscle specific differences in the responses to high- versus low-load exercise

Evolved Eclipsing Binaries and the Age of the Open Cluster NGC 752

We present analyses of improved photometric and spectroscopic observations for two detached eclipsing binaries at the turnoff of the open cluster NGC 752: the 1.01 day binary DS And and the 15.53 d BD $+$37 410. For DS And, we find $M_1 = 1.692\pm0.004\pm0.010 M_\odot$, $R_1 = 2.185\pm0.004\pm0.008 R_\odot$, $M_2 = 1.184\pm0.001\pm0.003 M_\odot$, and $R_2 = 1.200\pm0.003\pm0.005 R_\odot$. We either confirm or newly identify unusual characteristics of both stars in the binary: the primary star is found to be slightly hotter than the main sequence turn off and there is a more substantial discrepancy in its luminosity compared to models (model luminosities are too large by about 40%), while the secondary star is oversized and cooler compared to other main sequence stars in the same cluster. The evidence points to non-standard evolution for both stars, but most plausible paths cannot explain the low luminosity of the primary star. BD $+$37 410 only has one eclipse per cycle, but extensive spectroscopic observations and the TESS light curve constrain the stellar masses well: $M_1 = 1.717\pm0.011 M_\odot$ and $M_2 = 1.175\pm0.005 M_\odot$. The radius of the main sequence primary star near $2.9R_\odot$ definitively requires large convective core overshooting ($> 0.2$ pressure scale heights) in models for its mass, and multiple lines of evidence point toward an age of $1.61\pm0.03\pm0.05$ Gyr (statistical and systematic uncertainties). Because NGC 752 is currently undergoing the transition from non-degenerate to degenerate He ignition of its red clump stars, BD $+$37 410 A directly constrains the star mass where this transition occurs.Comment: 34 pages, 23 figures, accepted for Astronomical Journa

Evolved Eclipsing Binaries and the Age of the Open Cluster NGC 752

We present analyses of improved photometric and spectroscopic observations for two detached eclipsing binaries at the turnoff of the open cluster NGC 752: the 1.01 days binary DS And and the 15.53 days BD +37 410. For DS And, we find M1 = 1.692 ± 0.004 ± 0.010M⊙, R1 = 2.185 ± 0.004 ± 0.008R⊙, M2 = 1.184 ± 0.001 ± 0.003M⊙, and R2 = 1.200 ± 0.003 ± 0.005R⊙. We either confirm or newly identify unusual characteristics of both stars in the binary: the primary star is found to be slightly hotter than the main-sequence turnoff and there is a more substantial discrepancy in its luminosity compared to models (model luminosities are too large by about 40%), while the secondary star is oversized and cooler compared to other main-sequence stars in the same cluster. The evidence points to nonstandard evolution for both stars, but most plausible paths cannot explain the low luminosity of the primary star. BD +37 410 only has one eclipse per cycle, but extensive spectroscopic observations and the Transiting Exoplanet Survey Satellite light curve constrain the stellar masses well: M1 = 1.717 ± 0.011M⊙ and M2 = 1.175 ± 0.005M⊙. The radius of the main-sequence primary star near 2.9R⊙ definitively requires large convective core overshooting (>0.2 pressure scale heights) in models for its mass, and multiple lines of evidence point toward an age of 1.61 ± 0.03 ± 0.05 Gyr (statistical and systematic uncertainties). Because NGC 752 is currently undergoing the transition from nondegenerate to degenerate He ignition of its red clump stars, BD +37 410 A directly constrains the star mass where this transition occurs

Pulmonary Vaccination as a Novel Treatment for Lung Fibrosis

Pulmonary fibrosis is an untreatable, uniformly fatal disease of unclear etiology that is the result of unremitting chronic inflammation. Recent studies have implicated bone marrow derived fibrocytes and M2 macrophages as playing key roles in propagating fibrosis. While the disease process is characterized by the accumulation of lymphocytes in the lung parenchyma and alveolar space, their role remains unclear. In this report we definitively demonstrate the ability of T cells to regulate lung inflammation leading to fibrosis. Specifically we demonstrate the ability of intranasal vaccinia vaccination to inhibit M2 macrophage generation and fibrocyte recruitment and hence the accumulation of collagen and death due to pulmonary failure. Mechanistically, we demonstrate the ability of lung Th1 cells to prevent fibrosis as vaccinia failed to prevent disease in Rag−/− mice or in mice in which the T cells lacked IFN-γ. Furthermore, vaccination 3 months prior to the initiation of fibrosis was able to mitigate the disease. Our findings clearly demonstrate the role of T cells in regulating pulmonary fibrosis as well as suggest that vaccinia-induced immunotherapy in the lung may prove to be a novel treatment approach to this otherwise fatal disease

Changes in agonist neural drive, hypertrophy and pre-training strength all contribute to the individual strength gains after resistance training.

PURPOSE: Whilst neural and morphological adaptations following resistance training (RT) have been investigated extensively at a group level, relatively little is known about the contribution of specific physiological mechanisms, or pre-training strength, to the individual changes in strength following training. This study investigated the contribution of multiple underpinning neural [agonist EMG (QEMGMVT), antagonist EMG (HEMGANTAG)] and morphological variables [total quadriceps volume (QUADSVOL), and muscle fascicle pennation angle (QUADSθ p)], as well as pre-training strength, to the individual changes in strength after 12 weeks of knee extensor RT. METHODS: Twenty-eight healthy young men completed 12 weeks of isometric knee extensor RT (3/week). Isometric maximum voluntary torque (MVT) was assessed pre- and post-RT, as were simultaneous neural drive to the agonist (QEMGMVT) and antagonist (HEMGANTAG). In addition QUADSVOL was determined with MRI and QUADSθ p with B-mode ultrasound. RESULTS: Percentage changes (∆) in MVT were correlated to ∆QEMGMVT (r = 0.576, P = 0.001), ∆QUADSVOL (r = 0.461, P = 0.014), and pre-training MVT (r = -0.429, P = 0.023), but not ∆HEMGANTAG (r = 0.298, P = 0.123) or ∆QUADSθ p (r = -0.207, P = 0.291). Multiple regression analysis revealed 59.9% of the total variance in ∆MVT after RT to be explained by ∆QEMGMVT (30.6%), ∆QUADSVOL (18.7%), and pre-training MVT (10.6%). CONCLUSIONS: Changes in agonist neural drive, quadriceps muscle volume and pre-training strength combined to explain the majority of the variance in strength changes after knee extensor RT (~60%) and adaptations in agonist neural drive were the most important single predictor during this short-term intervention