63 research outputs found
Sinonasal B-cell lymphomas:A nationwide cohort study, with an emphasis on the prognosis and the recurrence pattern of primary diffuse large B-cell lymphoma
Lymphomas of the nasal cavity and paranasal sinuses (NPS) are rare. Knowledge on sinonasal Bâcell lymphoma (SNBCL) primarily comes from case series or singleâcenter studies on small cohorts. We sought to determine the subtype distribution, clinical characteristics, disease behavior, and prognosis on a nationwide scale, with an emphasis on prognostic factors for the most common sinonasal lymphoma, primary sinonasal diffuse large Bâcell lymphoma (PSDLBCL). We collated all data from medical records and national databases on patients registered with SNBCL from 1980 through 2018 in the national pathology registry and collected all tissue samples for validation of diagnosis. We included 205 patients and found 10 different subtypes of lymphoma. Diffuse large Bâcell lymphoma (DLBCL) was the predominant subtype (80%). The incidence of SNBCL was 0.14/100,000 personâyears. The fiveâyear progressionâfree survival (PFS) and overall survival rates for PSDLBCL were 50% and 56%, respectively. For PSDLBCL, Rituximab showed a statistically significant effect (Hazard Ratio 0.22, p < 0.001), whereas consolidative radiotherapy combined with immunochemotherapy was of limited value (PFS, p = 0.93). When treatment failure occurred, DLBCL showed a distinct pattern of recurrence/dissemination to the NPS, skin, breast, central nervous system (CNS), and/or testis. Collectively, DLBCL comprised a clear majority of SNBCLs, although nine other subtypes were represented. Data showed that immunochemotherapy increased survival for PSDLBCL and that the addition of radiotherapy did not benefit patients. Furthermore, treatment failure for sinonasal DLBCL showed a possible common pathogenesis with primary extranodal lymphomas of specific locations (e.g., CNS, skin, breast, and testis)
Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment
Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) treatment, which is used for hypertension, heart failure and diabetes complications. This candidate gene and genome-wide association study aimed to identify genetic variants predisposing to angioedema induced by these drugs. The discovery cohort consisted of 173 cases and 4890 controls recruited in Sweden. In the candidate gene analysis, ETV6, BDKRB2, MME, and PRKCQ were nominally associated with angioedema (p < 0.05), but did not pass Bonferroni correction for multiple testing (p < 2.89 Ă 10â5). In the genome-wide analysis, intronic variants in the calcium-activated potassium channel subunit alpha-1 (KCNMA1) gene on chromosome 10 were significantly associated with angioedema (p < 5 Ă 10â8). Whilst the top KCNMA1 hit was not significant in the replication cohort (413 cases and 599 ACEi-exposed controls from the US and Northern Europe), a meta-analysis of the replication and discovery cohorts (in total 586 cases and 1944 ACEi-exposed controls) revealed that each variant allele increased the odds of experiencing angioedema 1.62 times (95% confidence interval 1.05â2.50, p = 0.030). Associated KCNMA1 variants are not known to be functional, but are in linkage disequilibrium with variants in transcription factor binding sites active in relevant tissues. In summary, our data suggest that common variation in KCNMA1 is associated with risk of angioedema induced by ACEi or ARB treatment. Future whole exome or genome sequencing studies will show whether rare variants in KCNMA1 or other genes contribute to the risk of ACEi- and ARB-induced angioedema
High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach
Analysis and prioritization of future efforts for Danish biodiversity:with particular regard to Nature Agency lands
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The effect of road kills on amphibian populations
The diurnal movement patterns of Triturus vulgaris, T. cristatus, Pelobates fuscus, Bufo bufo, Rana temporaria, and R. arvalis were investigated during five breeding seasons (1994-1998). Two main questions were addressed: 1) What is the probability of an individual amphibian getting killed when crossing the road? and 2) What fraction of the amphibian populations gets killed by traffic? The rate of movement of 203 adult amphibians was recorded. Information on traffic loads was provided, and mortality risk was calculated depending on traffic loads and movement rate. The probability of getting killed ranged from 0.34 to 0.61 when crossing a road with a traffic load of 3,207 vehicles/day, and from 0.89 to 0.98 when crossing a motorway. The number of amphibians killed on the road was estimated by systematic counts. Population sizes were estimated for all ponds within 250m of the relevant highway stretch. Results indicate that about 10% of the adult population of P. fuscus and brown frogs (R. temporaria and R. arvalis) were killed annually by traffic at this site
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