632 research outputs found
Characterization of cadmium proteinuria in man and rat.
In workers chronically exposed to cadmium and without signs of renal insufficiency, plasma proteins with molecular weight ranging from 11,800 to 450,000 are excreted in greater amount in urine. Increased urinary excretion of low and high molecular weight proteins can occur independently. Because of its greater stability in urine and provided a sensitive immunological technique is used, the determination of retinol-binding protein is a more practical and reliable test of proximal tubular function than beta 2-microglobulin. The evaluation of renal function of workers removed from cadmium exposure indicates that cadmium-induced renal lesions, albeit of slow progression, are not reversible when exposures ceases. In workers chronically exposed to cadmium or removed from cadmium exposure, metallothionein in urine is directly correlated with cadmium in urine but not with cadmium in blood or years of cadmium exposure. The association between cadmium in urine and metallothionein in urine is independent of the status of renal function and the intensity of current exposure to cadmium. Whereas the repeated IP injection of high doses of cadmium to rat gives rise to a mixed or tubular type proteinuria, the prolonged oral administration of cadmium results mainly in the development of a glomerular type proteinuria. The former is usually reversible after cessation of treatment whereas the latter is not. Circulating antiglomerular basement membrane antibodies have been found in man and in rat chronically exposed to cadmium. The pathogenic significance of this finding deserves further investigation
Evidence for Spinodal Decomposition in Nuclear Multifragmentation
Multifragmentation of a ``fused system'' was observed for central collisions
between 32 MeV/nucleon 129Xe and natSn. Most of the resulting charged products
were well identified thanks to the high performances of the INDRA 4pi array.
Experimental higher-order charge correlations for fragments show a weak but non
ambiguous enhancement of events with nearly equal-sized fragments. Supported by
dynamical calculations in which spinodal decomposition is simulated, this
observed enhancement is interpreted as a ``fossil'' signal of spinodal
instabilities in finite nuclear systems.Comment: 4 pages, 4 figures, to be published in Phys. Rev. Letter
Response of CsI(Tl) scintillators over a large range in energy and atomic number of ions (Part I): recombination and delta -- electrons
A simple formalism describing the light response of CsI(Tl) to heavy ions,
which quantifies the luminescence and the quenching in terms of the competition
between radiative transitions following the carrier trapping at the Tl
activator sites and the electron-hole recombination, is proposed. The effect of
the delta rays on the scintillation efficiency is for the first time
quantitatively included in a fully consistent way. The light output expression
depends on four parameters determined by a procedure of global fit to
experimental data.Comment: 28 pages, 6 figures, submitted to Nucl. Inst. Meth.
Measurements of sideward flow around the balance energy
Sideward flow values have been determined with the INDRA multidetector for
Ar+Ni, Ni+Ni and Xe+Sn systems studied at GANIL in the 30 to 100 A.MeV incident
energy range. The balance energies found for Ar+Ni and Ni+Ni systems are in
agreement with previous experimental results and theoretical calculations.
Negative sideward flow values have been measured. The possible origins of such
negative values are discussed. They could result from a more important
contribution of evaporated particles with respect to the contribution of
promptly emitted particles at mid-rapidity. But effects induced by the methods
used to reconstruct the reaction plane cannot be totally excluded. Complete
tests of these methods are presented and the origins of the
``auto-correlation'' effect have been traced back. For heavy fragments, the
observed negative flow values seem to be mainly due to the reaction plane
reconstruction methods. For light charged particles, these negative values
could result from the dynamics of the collisions and from the reaction plane
reconstruction methods as well. These effects have to be taken into account
when comparisons with theoretical calculations are done.Comment: 27 pages, 15 figure
Multifragmentation process for different mass asymmetry in the entrance channel around the Fermi energy
The influence of the entrance channel asymmetry upon the fragmentation
process is addressed by studying heavy-ion induced reactions around the Fermi
energy. The data have been recorded with the INDRA 4pi array. An event
selection method called the Principal Component Analysis is presented and
discussed. It is applied for the selection of central events and furthermore to
multifragmentation of single source events. The selected subsets of data are
compared to the Statistical Multifragmentation Model (SMM) to check the
equilibrium hypothesis and get the source characteristics. Experimental
comparisons show the evidence of a decoupling between thermal and compresional
(radial flow) degrees of freedom in such nuclear systems.Comment: 28 pages, 15 figures, article sumitted to Nuclear Physics
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